Q9PJF9

PR
Gene name
thrS
Protein name
Threonine--tRNA ligase
Names
Threonyl-tRNA synthetase, ThrRS
Species
Chlamydia muridarum (strain MoPn / Nigg)
KEGG Pathway
cmu:TC_0870
EC number
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-69 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9PJF9

Entry ID Method Resolution Chain Position Source
AF-Q9PJF9-F1 Predicted AlphaFoldDB

No variants for Q9PJF9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9PJF9

No associated diseases with Q9PJF9

7 regional properties for Q9PJF9

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 312 - 522 IPR002314
domain TGS 1 - 58 IPR004095
domain Anticodon-binding 535 - 624 IPR004154
domain Aminoacyl-tRNA synthetase, class II 261 - 528 IPR006195
domain Threonyl/alanyl tRNA synthetase, SAD 164 - 213 IPR012947
domain Threonine-tRNA ligase catalytic core domain 237 - 533 IPR033728
domain Threonine-tRNA ligase, class IIa, anticodon-binding domain 533 - 623 IPR047246

Functions

Description
EC Number 6.1.1.3 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIHVTCNQEA FELPEGASAM DLASKMKNSH CFAGALINDQ EKDLSTTLKD GDTVLFLTWD
70 80 90 100 110 120
DPQGREIFLH TSAHILAQAV LRLWPSAQPT IGPVIDQGFY YDFANLSISE EDFPAIEAMA
130 140 150 160 170 180
KAIAEEKLAI SRQVFSDKEE TLAYFSDNPF KIELITELPE EATISAYKQG EFLDLCRGPH
190 200 210 220 230 240
LPSTAPVKAF KLLRTSAAYW RGDPSKESLI RIYGIAFPTT KELKEHLHQL EEAKKRDHRV
250 260 270 280 290 300
LGTKLDLFSQ QSYSAGMPFF HPRGMVIWNA LIDYWKRLHQ LAGYQQIQTP QLMSRELWEI
310 320 330 340 350 360
SGHWENYKEN MYTLTVDEED YAIKPMNCPG CMLYYKTQLH SYREFPLRIA EIGHVHRHEL
370 380 390 400 410 420
SGALSGLMRV RTFHQDDAHV FLTPEQVEEE TLNILNLVSE LYGTFGLDYH LELSTRPEQG
430 440 450 460 470 480
TIGSDDLWEL ATEALKNALV KSQKPFIISP GEGAFYGPKI DIHVKDAINR TWQCGTIQLD
490 500 510 520 530 540
MFLPERFDLK YTNPQGEKST PIMLHRALFG SIERFLGILI EHFKGRFPLW LSPEHVRIIT
550 560 570 580 590 600
VADRHEARAQ ELAKYFTQQG ILATVDQASE SVSKKIRNAQ NMQVNYMITI GDKELETQLL
610 620 630
AVRTRDNRVL NDISVEHFTN TILEELRSLS LTSSL