Q9PH12

PR
Gene name
valS
Protein name
Valine--tRNA ligase
Names
Valyl-tRNA synthetase, ValRS
Species
Xylella fastidiosa (strain 9a5c)
KEGG Pathway
xfa:XF_0134
EC number
6.1.1.9: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

585-656 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9PH12

Entry ID Method Resolution Chain Position Source
AF-Q9PH12-F1 Predicted AlphaFoldDB

No variants for Q9PH12

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9PH12

No associated diseases with Q9PH12

5 regional properties for Q9PH12

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 43 - 54 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 17 - 662 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 718 - 869 IPR013155
domain Valyl-tRNA synthetase, tRNA-binding arm 930 - 994 IPR019499
domain Valyl tRNA synthetase, anticodon-binding domain 661 - 808 IPR033705

Functions

Description
EC Number 6.1.1.9 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
valine-tRNA ligase activity Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+).

1 GO annotations of biological process

Name Definition
valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSQFTSSYDP TSFEARLYAA WEAAGHFKPS GTGQPYTILL PPPNVTGTLH MGHAFQQTLM
70 80 90 100 110 120
DALVRYHRMC GDDTLWQVGT DHAGIATEMV VSRNVVLEGH GETRDSLGRD GFINKVWEWK
130 140 150 160 170 180
QQSGDTIERQ MRRLGVSADW SRSTFTMDPQ PSAAVTEAFV RWYEAGLIYR GQRLVNWDPV
190 200 210 220 230 240
LKTAISDLEV ENVAEEGMLW SIRYPLSDGV TYEHVEHDAA GNEILRETRD SLIVATTRPE
250 260 270 280 290 300
TLLGDTAVMV HPEDRRYTAL IGKTVTLPLT GRHIPVIGDA YVDPTFGTGV VKVTPAHDFN
310 320 330 340 350 360
DYQIGLRHRL PMIQVLDDAA CIVSKTSIQS GMPSGATSDT TNTPSDPEAS SAANQHDTLV
370 380 390 400 410 420
MPAHLAGLDR YAARKQILAD LDAQGLLVAA IPHTLQVPRG DRTGQVIEPY LTAQWFVKME
430 440 450 460 470 480
TLAARGLALV ERGAVTFVPP NWINTYRHWM ENIQDWCISR QLWWGHRIPA WFDTQGGVYV
490 500 510 520 530 540
GRSEAEVRAK HALGPEVTLT QDNDVLETWF SSQLWPFSTL GWPDPTAMAE HGYARYLPSS
550 560 570 580 590 600
VLVTGFDIIF FWVARMIMAT DHFTGNVPFH DVYITGLIRD AQGQKMSKSK GNVLDPLDII
610 620 630 640 650 660
DGITLDDLVA KRTTGLMQPK LAEKIAKATR KEFPEGIAPH GADALRFTIA ALATHGRDIK
670 680 690 700 710 720
FDLGRAEGYK NFCNKLWNAT RFVLMNTADD TAHSPAQHQA GQDGQDAPRT PQPRTDAEQW
730 740 750 760 770 780
ILSRLTAITA EAHAQFAAYR FDLLAQALYE FAWNEFCDWF VELAKPALNS DDTQAAASTR
790 800 810 820 830 840
HTLLYVLETL LRLLHPLIPF ITEELWRQVA PRLGIQATTL MLRPYPQPQQ LETAAFANAA
850 860 870 880 890 900
ADVEWLKIMV SALRRIRSTL NVPPSRRVSL LLQGDQEVDR RRITHFATAL HFLLKLEHID
910 920 930 940 950 960
WLGADSAAPP SATAIVGTLK LLVPLEGLID VDAERVRLDK EIKRVESEID KSNGKLSNAV
970 980 990
FVQNAPAAVV EQERSRLTEW TTQLNGLRER RATL