Q9P974

PR
Gene name
TIF45 (CAGL0E01463g)
Protein name
Eukaryotic translation initiation factor 4E
Names
eIF-4E, eIF4E, eIF-4F 25 kDa subunit, mRNA cap-binding protein
Species
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
KEGG Pathway
cgr:CAGL0E01463g
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-93 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9P974

Entry ID Method Resolution Chain Position Source
AF-Q9P974-F1 Predicted AlphaFoldDB

No variants for Q9P974

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9P974

No associated diseases with Q9P974

1 regional properties for Q9P974

Type Name Position InterPro Accession
conserved_site Eukaryotic translation initiation factor 4E (eIF-4E), conserved site 88 - 111 IPR019770

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasmic stress granule A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
eukaryotic translation initiation factor 4F complex The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
mRNA cap binding Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an mRNA molecule.
phosphatidylinositol-3-phosphate binding Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

3 GO annotations of biological process

Name Definition
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
positive regulation of formation of translation preinitiation complex Any process that activates or increases the frequency, rate or extent of formation of translation preinitiation complex.
regulation of cell cycle Any process that modulates the rate or extent of progression through the cell cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSVDEVTKKF EETVSVDGPK TVLSDAKDFE VKHPLNTKWT LWYTKPAVDK SESWSDLLRP
70 80 90 100 110 120
VTSFQSVEEF WAIVQNIPEP HELPLKSDYH VFRNDIRPEW EDSANAKGGK WSFQVRGRGA
130 140 150 160 170 180
EIDELWLRTL LAVIGETIDE EDSQINGVVL NVRKGGNRFA LWTKSCDKEP LSNIGARFKQ
190 200
VLKLADEDTL EFFPHSTAND RHSQPTITL