Q9P7Y9
Gene name |
sin1 |
Protein name |
Target of rapamycin complex 2 subunit sin1 |
Names |
TORC2 subunit sin1, Stress-activated map kinase-interacting protein 1, SAPK-interacting protein 1 |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPAPYUG7.02c |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for Q9P7Y9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2RUJ | NMR | - | A | 247-400 | PDB |
| 2RVK | NMR | - | A | 247-400 | PDB |
| AF-Q9P7Y9-F1 | Predicted | AlphaFoldDB |
3 variants for Q9P7Y9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| I_4747722_A_T | 170 | L>I | No | Jeffares_SNPs | |
| I_4747397_A_T | 278 | F>Y | No | Jeffares_SNPs | |
| I_4747131_C_A | 367 | V>L | No | Jeffares_SNPs |
No associated diseases with Q9P7Y9
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| TORC2 complex | A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| phosphatidylinositol-4,5-bisphosphate binding | Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions. |
| signaling adaptor activity | The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| meiotic cell cycle | Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. |
| p38MAPK cascade | An intracellular protein kinase cascade containing at least a p38 MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. |
| positive regulation of conjugation with cellular fusion | Any process that increases the rate or frequency of conjugation with cellular fusion. |
| positive regulation of G2/M transition of mitotic cell cycle | Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle. |
| TORC2 signaling | A series of intracellular molecular signals mediated by TORC2; TOR (rapamycin-insensitive companion of TOR) in complex with at least Rictor (regulatory-associated protein of TOR), or orthologs of, and other signaling components. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MELTREKVLL | LTFLRMQYSH | ILPDSIENRV | ISTEAPEWEL | DKSLQDLLIH | DYDYSKTSFS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SSPPIVANDT | VSNVRKPSDT | KQVNGAGGQV | NHSRAEDSDY | ATSDLSESSD | VGDDDNSCIF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SFSKVPMQKD | VASIKEEERL | DPKISTLNNI | DAIANLKLTN | MVESSQAVNL | TSSKQSSINQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QSSVSTDYDD | LRSISEESFH | LSQGEIPLTF | PMNSSLTDTE | ADAVVAVDAL | FPGKQRGTHN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TVNKARSVSN | AKAPTSALRA | LLEHKENSSQ | NGPLAENFAT | FSGHAESNAL | RLNIYFPSSE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SPSKPLFVEL | RKNVLVSEAI | GYILLQYVNQ | QLVPPIEDEA | QNPNYWNLRI | VEDDGELDED |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FPALDRVGPL | SKFGFDAFAL | VKATPAQIKE | NQAAYPFKSK | HPTSIPEANN | KTHIRHTSST |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SSQSQKQAQD | VKDTLNTSHV | VQVRLPPYGD | NARFCNIEIS | KTTRLAMVLN | QVCWMKQLER |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FKYTLRVAGS | DTVLPLDKTF | SSLDGNPTLE | LVKKKVRDKK | GSTQQLPTSS | PQNSVYGSIK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KDAQSSTYNA | TDIMSSNTYQ | EFLVWKRQPV | SFMGRHERLL | AIDGEYVHIM | PSESKNIFET |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PKTSSIHAGS | IILCKQSKKS | PCNFKMIVSK | NRETKRYDFE | VLSALEAAII | VSRIRALMNT |
| VKKIN |