Q9P7R9
PR
Gene name |
cwf3 (syf1, SPBC211.02c) |
Protein name |
Pre-mRNA-splicing factor cwf3 |
Names |
Complexed with cdc5 protein 3 |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPBC211.02c |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q9P7R9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 3JB9 | EM | 360 A | r | 498-653 | PDB |
| AF-Q9P7R9-F1 | Predicted | AlphaFoldDB |
No variants for Q9P7R9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9P7R9 | |||||
No associated diseases with Q9P7R9
14 regional properties for Q9P7R9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | HAT (Half-A-TPR) repeat | 45 - 77 | IPR003107-1 |
| repeat | HAT (Half-A-TPR) repeat | 89 - 121 | IPR003107-2 |
| repeat | HAT (Half-A-TPR) repeat | 123 - 157 | IPR003107-3 |
| repeat | HAT (Half-A-TPR) repeat | 189 - 228 | IPR003107-4 |
| repeat | HAT (Half-A-TPR) repeat | 233 - 266 | IPR003107-5 |
| repeat | HAT (Half-A-TPR) repeat | 268 - 303 | IPR003107-6 |
| repeat | HAT (Half-A-TPR) repeat | 364 - 402 | IPR003107-7 |
| repeat | HAT (Half-A-TPR) repeat | 404 - 440 | IPR003107-8 |
| repeat | HAT (Half-A-TPR) repeat | 494 - 526 | IPR003107-9 |
| repeat | HAT (Half-A-TPR) repeat | 528 - 562 | IPR003107-10 |
| repeat | HAT (Half-A-TPR) repeat | 567 - 601 | IPR003107-11 |
| repeat | HAT (Half-A-TPR) repeat | 639 - 673 | IPR003107-12 |
| repeat | HAT (Half-A-TPR) repeat | 675 - 709 | IPR003107-13 |
| domain | Suppressor of forked | 204 - 305 | IPR008847 |
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| post-mRNA release spliceosomal complex | A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, including U5. |
| Prp19 complex | A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p. |
| spliceosomal complex | Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA. |
| U2-type catalytic step 2 spliceosome | A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs. |
| U2-type prespliceosome | A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| generation of catalytic spliceosome for first transesterification step | Formation of a catalytic spliceosome complex ready to perform the first splicing reaction. This occurs by an ATP-dependent conformational change of the pre-catalytic spliceosome. |
| mRNA cis splicing, via spliceosome | The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript. |
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGDVIPLKVN | FDLINVDDEP | FELELLRDPY | SLKSWLRYIK | THEGSTLEKR | VLLFERACSE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LPGSYKIWKS | YLELRVAHVE | HLNPYFHAEA | FASVNDCFER | SLILLHKMPV | IWKLYLQFLM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KQPNVTKIRC | TFNSALRALP | VTQHDDIWDM | FTKYAEDIGG | LFCIHVYRRY | IQVEPRAIEN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YIEILCKLGL | WNEAARQYED | ILNRPVFLSA | KRKSNYQIWL | EFSELVVQHP | DHTQNIDVEK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VFRAGIKRFS | DQAGKLWTYL | AQYYIRIGDY | EKARSTFYEG | MNNIMTVRNF | TIIFDAFVEF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EEQWLSARVE | ASSGNANDEL | SIDFHMAWLE | KILDKRPLYI | NDVLLRQNIN | NVDEWLRRVK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FLEDDSEKVV | QVYTDAIKNV | NPKLAHGSLG | KLFSEFARFY | ENFDDLEQSR | IIFEKATHVP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YKTVNELAQV | WIDWAEMELR | HQNFDAARKL | IGDAVHAPRK | SHISFFDESL | SPQVRLHKSS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KIWMYYLDLE | ESVGTIETTR | KLYDRVFELK | IATPQVVVNY | ANLLEENAYF | EDSFKIYERG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VALFSYPVAF | ELWNLYLTKF | VKRYQGTHME | RTRDLFEQAL | EGCPPEFSKS | IYLLYADFEE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KFGKAKRSIS | ILEKAADKVK | TADRLAIYNV | LLVKVALNYG | VLATRTVYEK | AIESLSDSEV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KDMCLRFAEM | ETKLGEIDRA | RLIYIHGSQY | CDPRVETDYW | KAWQEFEIRY | GNPEETVKEM |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LRIKRSVQTK | FSTDSLHIAK | RAAKIESAAA | PMDPMEQLEM | EKSEGPKALA | GFVLSKSNPQ |
| ETSKITGEEN |