Q9P7Q4

PR
Gene name
sec18 (SPAC1834.11c)
Protein name
Vesicular-fusion protein sec18
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC1834.11c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-74 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9P7Q4

Entry ID Method Resolution Chain Position Source
AF-Q9P7Q4-F1 Predicted AlphaFoldDB

7 variants for Q9P7Q4

Variant ID(s) Position Change Description Diseaes Association Provenance
I_4721106_C_T 4 R>K No Jeffares_SNPs
I_4721066_C_A 17 E>D No Jeffares_SNPs
I_4721064_T_G 18 Q>P No Jeffares_SNPs
I_4720081_C_T 346 V>I No Jeffares_SNPs
I_4719931_C_T 396 G>S No Jeffares_SNPs
I_4719714_T_C 468 N>S No Jeffares_SNPs
I_4719712_C_T 469 G>S No Jeffares_SNPs

No associated diseases with Q9P7Q4

8 regional properties for Q9P7Q4

Type Name Position InterPro Accession
domain CDC48, N-terminal subdomain 60 - 136 IPR003338
domain AAA+ ATPase domain 303 - 450 IPR003593-1
domain AAA+ ATPase domain 584 - 720 IPR003593-2
domain ATPase, AAA-type, core 307 - 447 IPR003959-1
domain ATPase, AAA-type, core 588 - 717 IPR003959-2
conserved_site ATPase, AAA-type, conserved site 418 - 436 IPR003960
domain CDC48, domain 2 163 - 235 IPR004201
domain AAA ATPase, AAA+ lid domain 474 - 509 IPR041569

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
Golgi stack The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.

6 GO annotations of biological process

Name Definition
endoplasmic reticulum to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
Golgi to plasma membrane protein transport The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane.
intra-Golgi vesicle-mediated transport The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network).
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
SNARE complex disassembly The disaggregation of the SNARE protein complex into its constituent components. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.
vacuole fusion, non-autophagic The fusion of two vacuole membranes to form a single vacuole.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDSRWKLPFM SNKGTPEQPM RKPLSGSYSH NSAGPTPNMS PFEQKPPLPT HMDVRRPSGP
70 80 90 100 110 120
FRIVKATSTE DALTNCIIVS PMDFKQQYII VDNSRVFSTK PVPGFPQGCL GASQPHREWA
130 140 150 160 170 180
SWSLNQQVHV ADYDPYGPHG APYLHSMTLE VDFQNRNRTT NEPFDGEEMA KLFCSSYQSQ
190 200 210 220 230 240
VFSPGQKIVF DFRSYNIKAT VRTISCVDLL IGENQDAENT ADTSKRGLLT SQTEIQFFKA
250 260 270 280 290 300
AHSALRLKAS MTRPASNAIL QPGFKFEDMG IGGLDSEFSA IFRRAFASRL FPPGMVEKLG
310 320 330 340 350 360
INHVKGILLY GPPGTGKTLI ARQIGKMLNA REPKIVNGPE ILNKYVGQSE ENVRKLFADA
370 380 390 400 410 420
EREYRDRGEE SGLHIIIFDE LDAICKKRGS SGGDTGVGDQ VVNQLLAKMD GVDQLNNILV
430 440 450 460 470 480
IGMTNRKDMI DEALLRPGRL EVHMEISLPD EHGRLQILKI HTSRMASNGI LENDVDMEEL
490 500 510 520 530 540
ASLTKNFSGA EIAGLIKSAS SFAFYRHIKV GTTAAVSGNL ENIKVNRNDF LNALSEVRPA
550 560 570 580 590 600
YGVSEEELES RVQGGIINFG KHIEEIITEG KLFVQQVKNS ERTRLVSVLL SGPIASGKTA
610 620 630 640 650 660
LAATIALGSE FPFVKLVSAE SMVGMNENAR VAHVNRVFED SYKSPLSVIV VDEIERIIDW
670 680 690 700 710 720
VPIGPRFSNT LLQTLMVLFK KQPPKGHRLL ILATTSERTM LSRMDMTQSF DAEIAVPNVS
730 740 750 760 770 780
NVTELDRIIQ SIDSFADSNV RADTLQRLQN FTGTDAVNVG VAKILMIAET AKQDVDVVSC
790
FVEAMARAIP ME