Q9P7B8
Gene name |
arb1 (SPAC140.03) |
Protein name |
Argonaute-binding protein 1 |
Names |
|
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPAC140.03 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9P7B8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9P7B8-F1 | Predicted | AlphaFoldDB |
9 variants for Q9P7B8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| I_1900143_T_C | 31 | L>P | No | Jeffares_SNPs | |
| I_1900221_G_T | 43 | W>C | No | Jeffares_SNPs | |
| I_1900564_A_G | 132 | T>A | No | Jeffares_SNPs | |
| I_1900625_C_T | 152 | A>V | No | Jeffares_SNPs | |
| I_1901107_A_T | 292 | R>S | No | Jeffares_SNPs | |
| I_1901121_G_A | 297 | R>Q | No | Jeffares_SNPs | |
| I_1901181_C_T | 317 | T>M | No | Jeffares_SNPs | |
| I_1901420_A_G | 397 | K>E | No | Jeffares_SNPs | |
| I_1901421_A_G | 397 | K>R | No | Jeffares_SNPs |
No associated diseases with Q9P7B8
No regional properties for Q9P7B8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9P7B8 | |||
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| ARC complex | A ribonucleoprotein complex that contains members of the Argonaute family of proteins, additional protein subunits, and duplex siRNA; required for heterochromatin assembly and siRNA generation. Possibly involved in the conversion of ds siRNA to ss siRNA. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| ribonuclease inhibitor activity | Binds to and stops, prevents or reduces the activity of ribonuclease. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| gene silencing by RNA | A process in which an RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation. |
| heterochromatin assembly by small RNA | A heterochromatin formation-based gene silencing process mediated by a small RNA molecule that occur before the beginnning of trancription. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAEGDFKNDS | TGCIGDSVEF | TTFKKRTGKS | LGNRRKKRGL | SGWEPYFQEP | ELTAEEKLEN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ETLYSRNIPL | TVRMERFIQR | YRSRRKWSDP | TRIRLFTMYL | DLGGVSTGQK | QFTGGTDINN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DAKAREVSAQ | TTTDYIEYDI | LDEYDIDFKW | VAGVFLSSHI | LYNAGLTKEE | DLQIACQIVR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NFLLSVLHNN | VAPEFEDNIR | DACLLAEQAE | TELISNKRLS | TKLPGRLQRA | LASIHVDNYK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GLWDKSQSDR | TSDSSVNFIE | SNNTKFMPND | ELFEPDGISR | FSTQQARDYI | QRTLGPRYLT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GKVVEQEYLT | VKLVSKTLLN | FSNQSLCKAV | FIVWDPPGSK | YSQDTNKERL | EVILESDLLN |
| 370 | 380 | 390 | |||
| NTVDGTHLEG | SFTFLDNGLT | ILDTVLAVLP | TFYEEVKDE |