Q9P772

PR
Gene name
gua1 (SPAP7G5.02c)
Protein name
GMP synthase [glutamine-hydrolyzing]
Names
GMP synthetase, Glutamine amidotransferase
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAP7G5.02c
EC number
6.3.5.2: Carbon--nitrogen ligases with glutamine as amido-N-donor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-45 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9P772

Entry ID Method Resolution Chain Position Source
AF-Q9P772-F1 Predicted AlphaFoldDB

4 variants for Q9P772

Variant ID(s) Position Change Description Diseaes Association Provenance
I_3734978_G_A 127 P>S No Jeffares_SNPs
I_3734816_T_C 181 K>E No Jeffares_SNPs
I_3734708_T_A 217 S>C No Jeffares_SNPs
I_3734707_C_G 217 S>T No Jeffares_SNPs

No associated diseases with Q9P772

4 regional properties for Q9P772

Type Name Position InterPro Accession
domain GMP synthase, C-terminal 220 - 539 IPR001674
domain GMP synthase, glutamine amidotransferase 21 - 212 IPR004739
domain Glutamine amidotransferase 23 - 208 IPR017926
domain GMP synthetase ATP pyrophosphatase domain 216 - 413 IPR025777

Functions

Description
EC Number 6.3.5.2 Carbon--nitrogen ligases with glutamine as amido-N-donor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GMP synthase activity Catalysis of the reaction: ATP + XMP + NH4(+) = AMP + diphosphate + GMP + 2H(+).
pyrophosphatase activity Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups.

2 GO annotations of biological process

Name Definition
glutamine catabolic process The chemical reactions and pathways resulting in the breakdown of glutamine, 2-amino-4-carbamoylbutanoic acid.
GMP biosynthetic process The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSSTEVPGEV STSVSSYFDT ILILDFGSQY SHLIARRLRE IHVYAELLPC TQKIEALPFK
70 80 90 100 110 120
PIGVILSGGP YSVYDDIAPH VDPAVFELGV PVLGICYGMQ EIAWLNGRCV EPGIEREYGP
130 140 150 160 170 180
ATVSMEPEIK TEVFKSFFNS MPKEFEVWMS HGDRLSALPN GYETIGRTKN SPFAVIAHVT
190 200 210 220 230 240
KPIIGLQFHP EVTHTPLGLQ LIKNFAIEIC HAKPNWSMEN FVDKEILRIR KMIGPSDHVI
250 260 270 280 290 300
GAVSGGVDST VASKVLKEAI GDRFHAIMVD NGLLRLNEAE IVRETLNKHL GIQLTVVDAS
310 320 330 340 350 360
EEFIGKLKGV TDPEKKRKII GNTFIHVFER EAERIVKETN GKVEYLLQGT LYPDVIESIS
370 380 390 400 410 420
FKGPSQTIKT HHNVGGLLKD MKLKLIEPLR ELFKDEVRAL GELLGIEHSL VWRHPFPGPG
430 440 450 460 470 480
LGIRILGEVN AAQLEIARKA DHIFITEIRN HGYYDKISQA FAALLPVKAV GVMGDKRTHE
490 500 510 520 530
QVIALRAITT SDFMTADWYD GFSIKFLKLV SSRICNEVSG VNRVLYDISS KPPATVEME