Q9P6Y2

PR
Gene name
tsp-2 (sen2, 13E11.340, NCU01115)
Protein name
Probable tRNA-splicing endonuclease subunit tsp-2
Names
tRNA-intron endonuclease sen2, tRNA-splicing protein 2
Species
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
KEGG Pathway
ncr:NCU01115
EC number
4.6.1.16: Phosphorus-oxygen lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-63 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9P6Y2

Entry ID Method Resolution Chain Position Source
AF-Q9P6Y2-F1 Predicted AlphaFoldDB

No variants for Q9P6Y2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9P6Y2

No associated diseases with Q9P6Y2

1 regional properties for Q9P6Y2

Type Name Position InterPro Accession
domain tRNA intron endonuclease, catalytic domain-like 505 - 594 IPR006677

Functions

Description
EC Number 4.6.1.16 Phosphorus-oxygen lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
tRNA-intron endonuclease complex A protein complex that catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron.

3 GO annotations of molecular function

Name Definition
lyase activity Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
nucleic acid binding Binding to a nucleic acid.
tRNA-intron endonuclease activity Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron.

1 GO annotations of biological process

Name Definition
tRNA-type intron splice site recognition and cleavage RNA processing that begins when the tertiary structure of a tRNA type intron is recognized, and ends when the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAENMTIATM AQPSESPSKS GEEAPASTNP AATSAPPRPP RVPYHQIYKL PAPIRTFPLP
70 80 90 100 110 120
TFYPSNPLSL FHLAVAWLRQ VLLPPPAEPS VIHEGIWDPD TRSVHVKDPK SIRALWEQGF
130 140 150 160 170 180
YGKGSLSRSE PNWFKRELSR RGLDGTTVSE ERTASRREER RQVKWERAKA ELEAIEKQKH
190 200 210 220 230 240
EEAKLNSETV NAAIPEPPAA EIEPEPEVLL SSLPDHVLSA TSTIPLSRAA PTNEFVPKTV
250 260 270 280 290 300
AHGHVEPKPP VGPLELLALP NSYALVRGEE LALSQPEPAP TEENVRKELK APVGPIELLA
310 320 330 340 350 360
LPNSLVDLVA LSVVSVLSED AGVDEDESST EDQLEASALT NDEPETSATE ANDSTSSSSP
370 380 390 400 410 420
PHTDGLPDSQ PTQENVPATP ERRKSVRFSS TVESTTFQHT DAASEVKNNN GSSDVEVFSS
430 440 450 460 470 480
FVSAVEKPVI LNVEPTVISQ ELVDKEHFQL APEEAFFLTF GLGALRVVDP VTEAPISNEQ
490 500 510 520 530 540
LLIKLRANSY FPPRSVDNLS PEDPFLVQYA VYHHFRSLGW VPRHGIKFGV DWIIYQRGPV
550 560 570 580 590 600
FDHSEFGIMV VPSFSDPRWS EFEHEESKKT WSWLMGVNRV LSHVLKSLVL VYVDVPPPPV
610 620 630
FDEEMKKGGI AAALKKFTIR EVMVRRFSVN RNR