Q9P6R9

PR
Gene name
cwf22 (SPBC13E7.01, SPBC15D4.16)
Protein name
Pre-mRNA-splicing factor cwf22
Names
Complexed with cdc5 protein 22
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC13E7.01
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

580-870 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9P6R9

Entry ID Method Resolution Chain Position Source
AF-Q9P6R9-F1 Predicted AlphaFoldDB

No variants for Q9P6R9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9P6R9

No associated diseases with Q9P6R9

2 regional properties for Q9P6R9

Type Name Position InterPro Accession
domain MIF4G-like, type 3 124 - 307 IPR003890
domain Initiation factor eIF-4 gamma, MA3 411 - 527 IPR003891

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
catalytic step 2 spliceosome A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
U2-type spliceosomal complex Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends.

1 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.

2 GO annotations of biological process

Name Definition
mRNA cis splicing, via spliceosome The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript.
mRNA splicing, via spliceosome The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEKEDKSFGI GMLDYNRENP ESSGHSRVAV IRKQKTEQEN NNLSWEDRHY IPDLHKSNKI
70 80 90 100 110 120
KTPTSLADEK KSHNELDPKA QIKKLMETRS GGTYIPPAKL KALQAQLTDV NTPEYQRMQW
130 140 150 160 170 180
EALKKSINGL INKVNKSNIR DIIPELFQEN IIRGRALYCR SIMKAQAASL PFTPIYAAMT
190 200 210 220 230 240
AVINTKFPQI GELLLTRLIV QFRKSFQRND KSMCISSSSF IAHLINQKIA HEIVGLQILA
250 260 270 280 290 300
VLLERPTNDS IEIAVMLLRE IGAYLAEVST RAYNGVFERF RTILHEGQLE RRTQFIIEVL
310 320 330 340 350 360
FQTRKDKFKN NPTIPQELDL VEEEDQITHY ISLDDNLDVQ ESLGIFHYDP DYEENEKKYD
370 380 390 400 410 420
AIKHEILGEE DDDENEEDEE DSEETSESEE DESVNDEKPQ VIDQTNASLV NLRKSIYLTI
430 440 450 460 470 480
MSSVDFEECC HKLLKIDLPE GQEIELCNMV IECNSQERTY AKFYGLIGER FCKLSRTWRS
490 500 510 520 530 540
TYEQCFKNYY ETIHRYETNR LRNIALFFAN LLSTDSIGWE VYDCVRLTED DTTASSRIFL
550 560 570 580 590 600
KIMFQEIVEA LGLKSLVERL HDPNLVPYLH GLFPVDEARN VRFSINYFTS IGLGALTEEM
610 620 630 640 650 660
REYLLTMPKS EPKEQDSEGY SSGSETGSTY SSSYSSTYSR GRSYSRSTRS YSKSRSYSRS
670 680 690 700 710 720
RSVTPINNIN HKKYIRKDRE LSPRGRERSS NRNSYSDLSR SSSLSRGRSR SYTPEGRLIE
730 740 750 760 770 780
SEDKGYRSRS SSPASRKYRS RQRYRRSYAG STSRGRSFSR SPSYRRRLSM SCSVSYSRSP
790 800 810 820 830 840
SPAARPISRS PARNKRSYDS LSYNRQYSPK VSRKRSNESR SPSPYTLRKQ KTYHLNKRNE
850 860 870 880
DFVVKMDKKG SESPVILAPW LREVDDGELY KDRNSESDSV RKQPRAD