Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9P6R0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9P6R0-F1 | Predicted | AlphaFoldDB |
No variants for Q9P6R0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9P6R0 | |||||
No associated diseases with Q9P6R0
6 regional properties for Q9P6R0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Brf1, TBP-binding domain | 387 - 488 | IPR011665 |
| domain | Zinc finger, TFIIB-type | 1 - 42 | IPR013137 |
| domain | Transcription factor TFIIB, cyclin-like domain | 79 - 166 | IPR013150-1 |
| domain | Transcription factor TFIIB, cyclin-like domain | 174 - 264 | IPR013150-2 |
| domain | Cyclin-like domain | 87 - 168 | IPR013763-1 |
| domain | Cyclin-like domain | 181 - 265 | IPR013763-2 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| transcription factor TFIIIB complex | A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIB contains the TATA-binding protein (TBP) and two Pol III-specific proteins, B'' and BRF. |
| transcription preinitiation complex | A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| RNA polymerase III general transcription initiation factor activity | A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase III. Factors required for RNA polymerase III transcription initiation include TFIIIA, TFIIIB and TFIIIC. RNA polymerase III transcribes genes encoding short RNAs, including tRNAs, 5S rRNA, U6 snRNA, the short ncRNA component of RNases P, the mitochondrial RNA processing (MRP) RNA, the signal recognition particle SRP RNA, and in higher eukaryotes a number of micro and other small RNAs, though there is some variability across species as to whether a given small noncoding RNA is transcribed by RNA polymerase II or RNA polymerase III. |
| RNA polymerase III type 3 promoter sequence-specific DNA binding | Binding to a sequence of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III (Pol III). A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae. |
| TBP-class protein binding | Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs). |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA-templated transcription initiation | The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place. |
| positive regulation of transcription by RNA polymerase III | Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase III. |
| RNA polymerase III preinitiation complex assembly | The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase III promoter. |
| transcription by RNA polymerase III | The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter. |
| transcription initiation at RNA polymerase III promoter | A transcription initiation process that takes place at a RNA polymerase III gene promoter. Transfer RNAs (tRNA) genes, as well as some other non-coding RNAs, are transcribed by RNA polymerase III. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGCPNCGSTT | FESDTASGNT | YCTQCGVVVE | QDAIVSEVTF | GEASTGAAVV | QGSLVSNDQT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HARTFGGPYR | NQGSVESREL | TIANGRRRIS | ALAIALKLNE | RHIEAAVRYF | TLAINNNFIK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GRRSQYVVAS | CLYIVCRISK | TSHMLIDFSD | ILQINVFKLG | STFLKLCRVL | RPNLPLLDPS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LYISRFASLL | EFGPETHRVA | NDAIRLVARM | NRDWMQIGRR | PAGICGACLL | IAARMNNFRR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SVREVVHVVK | VADITIQKRL | DEFKLTESGD | LSIADFRNIW | LEGQSDPPSF | TKNQKFQQYG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AQKVSNIDHT | QEYMSPIKRT | PDFDGNEVKS | EELSQTVKVE | SQETPVHLKA | DEREIRKEVT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ETLKGDELRK | ISLQVNVKFS | EEEVTLEDVD | DDEIEDILLD | KDEILTKTQV | WMELNKDYLA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EEEAKNLKLQ | EDLKKGIVRQ | PRKRRRYRPR | DSTSDGIADT | AAESAKEMMQ | QRAFSKKINY |
| 490 | |||||
| EALDMLFDEE | QS |