Q9P6M1

PR
Gene name
gst3 (SPAC688.04c)
Protein name
Glutathione S-transferase 3
Names
GST-III
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC688.04c
EC number
2.5.1.18: Transferring alkyl or aryl groups, other than methyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

196-242 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9P6M1

Entry ID Method Resolution Chain Position Source
AF-Q9P6M1-F1 Predicted AlphaFoldDB

3 variants for Q9P6M1

Variant ID(s) Position Change Description Diseaes Association Provenance
I_3116675_C_A 41 A>S No Jeffares_SNPs
I_3116566_G_C 77 P>R No Jeffares_SNPs
I_3116134_A_G 221 F>S No Jeffares_SNPs

No associated diseases with Q9P6M1

3 regional properties for Q9P6M1

Type Name Position InterPro Accession
domain Glutathione S-transferase, N-terminal 1 - 79 IPR004045
domain Glutathione S-transferase, C-terminal 121 - 204 IPR004046
domain Glutathione S-transferase, C-terminal-like 85 - 234 IPR010987

Functions

Description
EC Number 2.5.1.18 Transferring alkyl or aryl groups, other than methyl groups
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

3 GO annotations of molecular function

Name Definition
glutathione binding Binding to glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine.
glutathione peroxidase activity Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O.
glutathione transferase activity Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.

1 GO annotations of biological process

Name Definition
removal of superoxide radicals Any process, acting at the cellular level, involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIVLHHLKNS RSTRIVWMLE ELKVPYEIKV YDRVDGRAPP AYTKLSPLGK SPIVVDDGVT
70 80 90 100 110 120
YIESAAILEH LVRKYGPSFK PSEEDVAELE KYELWMHFSE ASLMPFIWAS HVLDLSVNMT
130 140 150 160 170 180
PIFFRYIVRQ FVNGIKSKYL SKETFLNLDY IDNHLASNEY FAGEQFTAAD PQMCFPIFAA
190 200 210 220 230 240
QRDYLSQKPY KNIKRWMRVV SDRPACRIAA EKVEDNTLTL FSDVERYSHP PTPPPEQVRS
DE