Q9P6J1

PR
Gene name
icl2 (SPBC1683.11c)
Protein name
Mitochondrial 2-methylisocitrate lyase
Names
Methylisocitrate lyase
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC1683.11c
EC number
4.1.3.30: Oxo-acid-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-63 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9P6J1

Entry ID Method Resolution Chain Position Source
AF-Q9P6J1-F1 Predicted AlphaFoldDB

No variants for Q9P6J1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9P6J1

No associated diseases with Q9P6J1

1 regional properties for Q9P6J1

Type Name Position InterPro Accession
domain ICL/PEPM domain 60 - 249 IPR039556

Functions

Description
EC Number 4.1.3.30 Oxo-acid-lyases
Subcellular Localization
  • Mitochondrion matrix
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.

2 GO annotations of molecular function

Name Definition
isocitrate lyase activity Catalysis of the reaction: isocitrate = glyoxylate + succinate.
methylisocitrate lyase activity Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate.

1 GO annotations of biological process

Name Definition
threonine catabolic process The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTTDMDLEQL EYEKEVEEIE KWWATPKQSQ IKRPYTASTV AVLSEVTKAY YPSSQQALKL
70 80 90 100 110 120
YDLLREHRNK GTATLTYGVV DPVLASQASK AGLETIFVSG CLCGLSSVDE PGMDHADYPW
130 140 150 160 170 180
DTVPKAVDRI FRSQNWHARR QKQFHLMKPA EERKQLPKYD YLLPIIADGD MGFGSVTSTM
190 200 210 220 230 240
KMTKRFVESG VAMIHLDDLA IGLKRFTVGQ GRTVVPTSEY LRRLTAVRLQ FDIMKAETML
250 260 270 280 290 300
LCRCDTDHAE FITSVVDPRD HAYVLGATTK IESLIKALKD AESTGVSMKK ARENWIERAK
310 320 330 340 350 360
LMTFDEAVKS TATPKEYENY ISAISKKPFH SISERQELAE KYLSNEVFFD WELPRSSDGQ
370 380 390 400 410 420
YFFKPTVQTV IERAIAAAPL GEMTWARMDY PKWQDIKAFH EGVRAVYPDR MFAFGFTGNY
430 440 450 460 470 480
DFKAAGFSEE QLRNLTSDMA KLGVCWQVQP YFTCQVLNKA SVDYSNIWKK DGIFGYVKTV
490 500 510
QEPALKEDVD GFENEWCGTY FADKLLSAAG SSDKTIPY