Q9P3W5
Gene name |
tel2 (SPAC458.03) |
Protein name |
DNA replication checkpoint protein tel2 |
Names |
|
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPAC458.03 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9P3W5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9P3W5-F1 | Predicted | AlphaFoldDB |
17 variants for Q9P3W5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| I_4734989_G_C | 43 | S>T | No | Jeffares_SNPs | |
| I_4735014_T_A | 51 | N>K | No | Jeffares_SNPs | |
| I_4735259_C_T | 133 | T>I | No | Jeffares_SNPs | |
| I_4735343_C_T | 161 | S>L | No | Jeffares_SNPs | |
| I_4735423_G_A | 188 | A>T | No | Jeffares_SNPs | |
| I_4735468_T_G | 203 | L>V | No | Jeffares_SNPs | |
| I_4735606_C_T | 249 | H>Y | No | Jeffares_SNPs | |
| I_4735738_G_A | 293 | G>S | No | Jeffares_SNPs | |
| I_4735892_C_T | 344 | A>V | No | Jeffares_SNPs | |
| I_4736053_G_A | 398 | V>I | No | Jeffares_SNPs | |
| I_4736077_A_G | 406 | S>G | No | Jeffares_SNPs | |
| I_4736246_A_T | 462 | H>L | No | Jeffares_SNPs | |
| I_4736389_G_A | 510 | V>I | No | Jeffares_SNPs | |
| I_4736513_C_T | 551 | A>V | No | Jeffares_SNPs | |
| I_4736554_T_A | 565 | F>I | No | Jeffares_SNPs | |
| I_4737142_G_A | 761 | V>I | No | Jeffares_SNPs | |
| I_4737338_A_G | 826 | K>R | No | Jeffares_SNPs |
No associated diseases with Q9P3W5
5 regional properties for Q9P3W5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Zinc finger, LIM-type | 271 - 330 | IPR001781-1 |
| domain | Zinc finger, LIM-type | 331 - 388 | IPR001781-2 |
| domain | Zinc finger, LIM-type | 389 - 448 | IPR001781-3 |
| domain | Zinc finger, LIM-type | 449 - 506 | IPR001781-4 |
| domain | Paxillin/TGFB1I1, LIM domain 1 | 273 - 325 | IPR047075 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| ASTRA complex | A protein complex that is part of the chromatin remodeling machinery; the acronym stands for ASsembly of Tel, Rvb and Atm-like kinase. In Saccharomyces cerevisiae this complex includes Rvb1p, Rvb2p, Tra1p, Tel2p, Asa1p, Ttilp and Tti2p. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| TTT complex | A protein complex responsible for the stabilisation of protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex can also be found as part of the ASTRA complex (GO:0070209). |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| Hsp90 protein binding | Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size. |
| telomeric DNA binding | Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| mitotic DNA replication checkpoint signaling | A signal transduction process that contributes to a mitotic DNA replication checkpoint. |
| protein stabilization | Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. |
| telomere maintenance via telomerase | The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKSFASELSK | PIQKPRLKEI | LKELQHIGVP | SPCNLRLYHE | LISVIVPTFW | NGKINSEIDF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LLAKCFSTLL | GLKLLCVRLD | NFVQEANLQN | IHLVTVYLEL | LEKAFECIDL | DDNCKLIWES |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TVLSDHQKQS | LWTEFIFFLG | NFKITNSMSA | AMLTFKVYDD | SKRLKASSMA | DYIGVLSSKL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ACIISKPAVK | TPEIYSKLFH | YLLHSSNLKA | FINPLIPLTQ | KFCVQLQKLF | ADLTVSDQML |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FLNQLLLEHN | TKYPTNFSYS | TARDDRITGS | LATLLRLNFS | STHFLRLIEF | YWGVPTNLII |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KRVEVVCSSI | SYKESDKKEL | EKTVDSLFNI | WSNAQFLRSY | TLLAQESLTI | YLLLFIPKLE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AKYLNNLSKS | LMFSNAISCR | LDSLDDDIRM | HGMIMAEVIS | TYSGVSLSNP | LAFDVPIMKT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TKAKVLKSLS | SLKDEFLPIE | ILNDESVIAE | TSIEKEETNV | THLEKPVISK | NDDLIRGDDL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EPYDFPDIDS | EDTDDDPTVS | RSKTHSPVYV | QDLCKMLKDT | ESFEKQRVAL | ENASKLIKRK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SAFGTELRDH | ADELLQTLIS | LQNRFDLMNF | DEMQMTAIVE | LLLTCLDICG | PVICTNLFVS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| DYSMRQKILI | LSCISLAASK | FNDDDNERLF | PSQLLPGNLH | DQFYSPTIEK | ISDELERKLV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| FPVMSECKDY | AEGPKFLQTR | YISKQSEIES | KKPLPKANRL | SLKVDKSLFL | LLTSGYMLAS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| RKTAFIEPLF | LVYYLKTLGI | LFFETFTSKI | EGANRMLREY | VDVLNEVCRL | RSDTPEVNEG |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LLFSFLAILE | ISSGRTLANE | FGKHLLFFEA | YTKFLFESPD | QGEKVKSLSA | AVLILFENKL |
| 850 | 860 | ||||
| SEFRTLALEK | LLDDSAPLVP | ERFGLAGL |