Q9P3W4

PR
Gene name
dil1 (SPAC458.04c)
Protein name
Dynein intermediate light chain dil1
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC458.04c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

305-360 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9P3W4

Entry ID Method Resolution Chain Position Source
AF-Q9P3W4-F1 Predicted AlphaFoldDB

5 variants for Q9P3W4

Variant ID(s) Position Change Description Diseaes Association Provenance
I_4738841_A_G 5 L>S No Jeffares_SNPs
I_4738669_A_C 50 S>A No Jeffares_SNPs
I_4738533_T_A 81 H>L No Jeffares_SNPs
I_4737940_T_C 250 I>V No Jeffares_SNPs
I_4737749_T_C 313 I>M No Jeffares_SNPs

No associated diseases with Q9P3W4

No regional properties for Q9P3W4

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9P3W4

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton
  • Localized to the leading edge of the horsetail nucleus, where the spindle pole body (SPB) is expected, and to the leading microtubules
  • In cycling cells, forms foci which distributed asymmetrically during cell division
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

9 GO annotations of cellular component

Name Definition
cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
cortical microtubule cytoskeleton The portion of the microtubule cytoskeleton that lies just beneath the plasma membrane.
cortical microtubule plus-end The plus-end of a cortical microtubule.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic dynein complex Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
meiotic spindle pole body The microtubule organizing center that forms as part of the meiotic cell cycle; functionally homologous to the animal cell centrosome.
microtubule cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
nucleus leading edge The area of a motile nucleus closest to the direction of movement.

1 GO annotations of molecular function

Name Definition
dynein heavy chain binding Binding to a heavy chain of the dynein complex.

3 GO annotations of biological process

Name Definition
dynein-driven meiotic oscillatory nuclear movement Oscillatory movement of the nucleus involved in meiosis I. This oscillatory movement is led by an astral microtubule array emanating from the spindle pole body, and driven by the microtubule motor cytoplasmic dynein.
microtubule cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
microtubule-based movement A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDELLEKLLN DLKKKEPKAC SIICIGEDLD IIQCMNEHGC FSGGSYSELS NDCETVNFRG
70 80 90 100 110 120
IAYKCFFTKD QVKVNFWQIS HLTGGLFNFL VSQALNEHGL DLLWIIMVVA QTLSALVSFP
130 140 150 160 170 180
EKLLNILRNM KTILINTEET VRNRFEESQN KKLVALLDKN STTLDISSGI LLNFTVVLKQ
190 200 210 220 230 240
LKHALGLHTS VDNSQEFILQ FLRTTLLSVP TSSIVSISAD PTSWNNLNVL MKYNFMFQKF
250 260 270 280 290 300
KPRDFHAQTI QSETMFIPPC WDTISKIQSV NHEFNIALFK QTAKNFYDTL DISLLLGLFD
310 320 330 340 350
KSISMLNCHS SKISDGDIPY KSHQVFLQEL QNKYSEIKTY SSNKLNKSSI KSSLWKDLIQ