Q9P3T8

PR
Gene name
cin2 (SPAC328.08c)
Protein name
Tubulin-specific chaperone C
Names
Tubulin-folding cofactor C, CFC
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC328.08c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-140 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9P3T8

Entry ID Method Resolution Chain Position Source
AF-Q9P3T8-F1 Predicted AlphaFoldDB

9 variants for Q9P3T8

Variant ID(s) Position Change Description Diseaes Association Provenance
I_3493952_C_T 51 V>I No Jeffares_SNPs
I_3493888_C_T 72 R>Q No Jeffares_SNPs
I_3493810_G_A 98 S>F No Jeffares_SNPs
I_3493763_C_G 114 V>L No Jeffares_SNPs
I_3493522_C_T 194 C>Y No Jeffares_SNPs
I_3493246_C_T 209 R>H No Jeffares_SNPs
I_3493244_C_T 210 V>M No Jeffares_SNPs
I_3493217_C_T 219 V>I No Jeffares_SNPs
I_3493105_A_G 256 L>P No Jeffares_SNPs

No associated diseases with Q9P3T8

No regional properties for Q9P3T8

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9P3T8

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
tubulin folding cofactor complex A multimeric protein complex involved in tubulin alpha-beta-subunit folding assembly consisting of beta-tubulin-TFC-D, alpha-tubulin-TFC-E and TFC-C, through which tubulin subunit association and dimer release occur.

1 GO annotations of molecular function

Name Definition
GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.

3 GO annotations of biological process

Name Definition
post-chaperonin tubulin folding pathway Completion of folding of alpha- and beta-tubulin; takes place subsequent to chaperonin-mediated partial folding; mediated by a complex of folding cofactors.
protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
tubulin complex assembly The aggregation and bonding together of alpha- and beta-tubulin to form a tubulin heterodimer.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSEKFVELRK EFLTKLYKST PSEQTSRSEK ETWLEEKSKY LGEMTRELNE VQDQIAPYDR
70 80 90 100 110 120
RVCMEQLVDL TRRLQQIRHD ILPRQPFRFQ RALHVKSSQK PVKNITVNAE APEVYFENDT
130 140 150 160 170 180
LYLANLKNQN IGDNVIPYPN NKAVKVSAKS LRSCNISISN CSSVNLHNAT KCNFTFPTIQ
190 200 210 220 230 240
GSIHLSDIND STICVSCHQF RLHHSTNLRV HLRCKTSPVI EESKEISFSY KDEHPILDFT
250
WARSDPSPHF RITSDLFDA