AiPD: Autoinhibited Protein Database

Gene name	SPAC1565.02c
Protein name	Putative Rho GTPase-activating protein C1565.02c
Names
Species	Bos taurus (Bovine)
KEGG Pathway	spo:SPAC1565.02c
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Target domain	170-352 (RhoGAP domain)
Relief mechanism	Ligand binding
Assay	Deletion assay, Mutagenesis experiment, Structural analysis

1-156 (Lipid binding domain, BCH domain)

170-352 (RhoGAP domain)

Ligand binding (Lipid binding to BCH domain)

Deletion assay, Mutagenesis experiment, Structural analysis

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
7E0W	X-ray	280 A	A/B/C/D	2-156	PDB
AF-Q9P3B1-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
I_1293766_C_T	13	G>D	No	Jeffares_SNPs
I_1293419_C_T	108	R>Q	No	Jeffares_SNPs
I_1293402_C_T	114	A>T	No	Jeffares_SNPs
I_1293189_C_T	185	G>S	No	Jeffares_SNPs
I_1293184_C_T	186	M>I	No	Jeffares_SNPs
I_1293033_G_A	237	H>Y	No	Jeffares_SNPs
I_1292939_C_A	268	S>I	No	Jeffares_SNPs
I_1292621_G_T	374	P>Q	No	Jeffares_SNPs

Type	Name	Position	InterPro Accession
domain	Fork head domain	174 - 266	IPR001766

		Description
EC Number
Subcellular Localization	Cytoplasm, cytosol Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cell cortex	The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
cell division site	The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.

Name	Definition
GTPase activator activity	Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
phospholipid transfer activity	Removes a phospholipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.

Name	Definition
intermembrane phospholipid transfer	The transport of phospholipids between membranes in which a phospholipid molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane.
small GTPase mediated signal transduction	The series of molecular signals in which a small monomeric GTPase relays a signal.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins