Q9P377

PR
Gene name
bgs3 (SPAC19B12.03)
Protein name
1,3-beta-glucan synthase component bgs3
Names
1,3-beta-D-glucan-UDP glucosyltransferase
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC19B12.03
EC number
2.4.1.34: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-123 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9P377

Entry ID Method Resolution Chain Position Source
AF-Q9P377-F1 Predicted AlphaFoldDB

7 variants for Q9P377

Variant ID(s) Position Change Description Diseaes Association Provenance
I_4884710_T_A 238 L>Q No Jeffares_SNPs
I_4885171_G_T 392 A>S No Jeffares_SNPs
I_4886691_G_T 898 L>F No Jeffares_SNPs
I_4886867_A_G 957 D>G No Jeffares_SNPs
I_4886882_G_A 962 R>K No Jeffares_SNPs
I_4888600_G_A 1535 V>I No Jeffares_SNPs
I_4889351_T_C 1785 V>A No Jeffares_SNPs

No associated diseases with Q9P377

1 regional properties for Q9P377

Type Name Position InterPro Accession
domain 1,3-beta-glucan synthase component FKS1-like, domain-1 271 - 383 IPR026899

Functions

Description
EC Number 2.4.1.34 Hexosyltransferases
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
  • Found at the growing tips during interphase and at the septum prior to cytokinesis
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
1,3-beta-D-glucan synthase complex A protein complex that catalyzes the transfer of a glucose group from UDP-glucose to a (1->3)-beta-D-glucan chain.
cell division site The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
cell tip The region at the end of the longest axis of a cylindrical or elongated cell.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
site of polarized growth Any part of a cell where non-isotropic growth takes place.

2 GO annotations of molecular function

Name Definition
1,3-beta-D-glucan synthase activity Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + [(1->3)-beta-D-glucosyl](n+1).
glucosyltransferase activity Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid.

5 GO annotations of biological process

Name Definition
(1->3)-beta-D-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds.
beta-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of beta-glucans.
fungal-type cell wall (1->3)-beta-D-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in fungal cell walls.
fungal-type cell wall biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a fungal-type cell wall. The fungal-type cell wall contains beta-glucan and may contain chitin.
fungal-type cell wall polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of the polysaccharides which make up the fungal-type cell wall.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDYKKGEHSP SSSIQILSDD ATINSNYAYG EQLQSNDQYN NIQHPAPSFA NPFIHEQDDS
70 80 90 100 110 120
YSDILEEEPD EDAYDSPERP SSTEEFISQD ESNISAGSSF MFPYNRGHPL SKRHDSIMVD
130 140 150 160 170 180
EFGHEYIVEG DSIASADEAI DYDALYASWT AETKAPILAI DIENIYIELA MKFGFQWDNM
190 200 210 220 230 240
RNMFDYLMVM LDSRASRMTP QEALLTLHAD YIGGPQSNFK KWYFACKMDQ FDLKSGVLSF
250 260 270 280 290 300
ISRDPSTQVP YKDMSSCEAL WISRMDELSN YERIEQLALY LLCWGEANNV RFMPECLCFI
310 320 330 340 350 360
YKVAYDYLIS PSFKEQKNPA PKDYFLDNCI TPLYNLMHDQ QYEIRDQKYV RKEKDHASII
370 380 390 400 410 420
GYDDINQMFW YSKGLKALLL SDGSRIMDAD VASRYFLLAD IQWQRVCYKS FRESRTWLHF
430 440 450 460 470 480
LHNFSRIWIL HISVFWYFTV YNSPTIYTPN FHYLEGTQPA RAAKWCAPAL AGAVASFISF
490 500 510 520 530 540
LALILEAYFV PRNNPGAQPV IPRLIFVSIL IALNIVPAAF IFGFSNATQQ HYRSREIVGY
550 560 570 580 590 600
VHFFFSIGCV AYQSFIPLPF LLGPRFKFRS SSRKYLANSY FTNDIASLPW GRTLLSAALW
610 620 630 640 650 660
ITVFIAKFVE SYYFLTLSVR DPIRFLQRMK PYDCYDFMIG ASLCSHQPKF LLSLVYLTDL
670 680 690 700 710 720
VLFFLDTYLW YMLISTMFSI AYSFYMGSAI WTPWRVIFSN LPRRIYFTLL AYKDLSTEFK
730 740 750 760 770 780
PKIYVGQIWN SIMISMYREH LLSLEHLKGL LYQQVGSEYF GKQTFQSPKF FMEAAKGLNK
790 800 810 820 830 840
WDAFFRRNSE AERRISFFAQ SLGGKIPDAV PVPKMPSFTV LIPHYGEKIL LSLREIIREQ
850 860 870 880 890 900
DPMSRITLLE YLKQLYPNDW DNFVQDTKLM AGDVGVEETK SDVKSEKGKK QGTVKEDLPF
910 920 930 940 950 960
YCIGFKSTAP EYTLRTRIWA SLRSQTLYRT ASGMMNYSRA LKLLYRVEQP NLLDDCDGNF
970 980 990 1000 1010 1020
ERLEHQLEQM AYRKFRLCIS MQRYAKFNRD EYENAEFLLR AHPELQIAYL DQDPSEDGEE
1030 1040 1050 1060 1070 1080
PKVYATLING FCPFENGRRL PKYRIRLSGN PILGDGKADN QNMALPFVRG EYLQLIDANQ
1090 1100 1110 1120 1130 1140
DNYIEECMKI RNVLSEFEEM DCATLTPYTK KGNARHPVAM LGAREYVFSE NSGILGDVAA
1150 1160 1170 1180 1190 1200
GKEQTFGTLF SRSLALIGGK LHYGHPDFLN TIFMTTRGGV SKAQKGLHVN EDIYAGMTAL
1210 1220 1230 1240 1250 1260
QRGGRIKHCD YFQCGKGRDL GFGTIINFTT KIGTGMGEQS LSREYFYLGT QLPFFRMLSF
1270 1280 1290 1300 1310 1320
YYAHAGFHLN NVFIMISMQL LMLVFVNLGA MYHTVEICDY QAGAAINASL YPPGCYMLKP
1330 1340 1350 1360 1370 1380
VLDWIRRCII SIFIVFFISF LPLVVHDLLE KGVIRAVARL CKQIFSLSPM FEVFVTQNYA
1390 1400 1410 1420 1430 1440
NSIFTNLTYG GARYIATGRG LATTRVPFSV LYSLYTGSSI YLGSRLIMML LFGTMTVWTT
1450 1460 1470 1480 1490 1500
HYVYFWVTMF ALVICPFIYN PHQFSFVDFF VDYREFLRWL SRGNTKGHAH SWIGFCRLAR
1510 1520 1530 1540 1550 1560
TRITGVNRKV KGSPSNKLTM DMPRAGLRNV IFTEVFLPAC FAFFTICAYT FMNSQPGLED
1570 1580 1590 1600 1610 1620
KSRAVNGFIR IWIMAALPIA ISTAALLILL MFSCMLGPLL RKCSKRYGAV LAALAHAVSV
1630 1640 1650 1660 1670 1680
FGLVFTFEAL WFLEAWSFSK TVLGCIVIFA IHRLVFKLVV VFLLPREVAS GENNYSWWDG
1690 1700 1710 1720 1730 1740
HWFGRKGIPY MPIQFIREFM CKVVEMNLFA MDFILSHCIL FSLTPILCIP FIDIPHSVLL
1750 1760 1770 1780 1790 1800
FWLHPSRQIR PPIYTRKQNQ LRRRTFYRYS LLFFALLCTF VAMIVVPLVL DQKLSYQFKF
1810 1820
ENSVKFFRLM QPSLGVLPNT NKNTSE