AiPD: Autoinhibited Protein Database

Q9NZ43

Gene name	USE1 (USE1L, MDS032)
Protein name	Vesicle transport protein USE1
Names	Putative MAPK-activating protein PM26, USE1-like protein, p31
Species	Homo sapiens (Human)
KEGG Pathway	hsa:55850
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

44-247 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

44-247 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9NZ43

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9NZ43-F1	Predicted				AlphaFoldDB

247 variants for Q9NZ43

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1453586667 CA404723098	2	A>S		No	ClinGen TOPMed
rs1310060663 CA404723100	2	A>V		No	ClinGen gnomAD
rs1245211509 CA404723104	3	A>T		No	ClinGen TOPMed gnomAD
CA404723131 rs1434789235	5	R>K		No	ClinGen TOPMed gnomAD
CA404723137 rs371968820	5	R>S		No	ClinGen gnomAD
rs746528926 CA9288948	6	L>P		No	ClinGen ExAC gnomAD
rs746528926 CA404723146	6	L>Q		No	ClinGen ExAC gnomAD
CA404723152 rs1258483909	7	E>K		No	ClinGen gnomAD
CA404723170 rs1181507260	8	L>P		No	ClinGen gnomAD
rs1473854569 CA404723189 CA404723187	9	N>K		No	ClinGen TOPMed gnomAD
rs931086126 CA306073270	10	L>V		No	ClinGen TOPMed
CA9288950 rs780809965	11	V>A		No	ClinGen ExAC gnomAD
CA9288952 rs770032377	14	L>I		No	ClinGen ExAC gnomAD
CA306073280 rs866900872	14	L>P		No	ClinGen Ensembl
rs982954543 CA306073292	15	S>C		No	ClinGen TOPMed gnomAD
rs982954543 CA306073284	15	S>F		No	ClinGen TOPMed gnomAD
rs982954543 CA404723238	15	S>Y		No	ClinGen TOPMed gnomAD
CA9288953 rs775944547	16	R>P		No	ClinGen ExAC gnomAD
rs867902713 CA306073294	16	R>S		No	ClinGen gnomAD
CA404723281 rs1288855161	19	A>T		No	ClinGen gnomAD
rs769289561 CA9288955	19	A>V		No	ClinGen ExAC TOPMed gnomAD
CA9288956 rs530342370	20	M>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1258038351 CA404723308	21	A>S		No	ClinGen gnomAD
rs369914957 CA9288957	22	A>S		No	ClinGen ESP ExAC gnomAD
CA306073315 rs867247862	22	A>V		No	ClinGen gnomAD
rs767768753 CA9288958	23	E>D		No	ClinGen ExAC gnomAD
rs1173453355 CA404723324	23	E>K		No	ClinGen TOPMed
rs1484206735 CA404723339	24	K>E		No	ClinGen gnomAD
rs867349560 CA306073320	25	R>L		No	ClinGen Ensembl
CA306073319 rs931893731	25	R>W		No	ClinGen Ensembl
CA9288960 rs761009949	26	D>G		No	ClinGen ExAC TOPMed gnomAD
rs373033987 CA9288959	26	D>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA306073324 rs932674864	27	P>A		No	ClinGen TOPMed gnomAD
CA306073326 rs550089290 CA404723394	28	D>E		No	ClinGen 1000Genomes TOPMed gnomAD
CA404723383 rs1466238386	28	D>N		No	ClinGen gnomAD
CA404723386 rs1466238386	28	D>Y		No	ClinGen gnomAD
rs1368499941 CA404723420	30	W>S		No	ClinGen gnomAD
CA306073330 rs1043507161	31	R>H		No	ClinGen TOPMed
CA404723449 rs1317174565	33	E>D		No	ClinGen TOPMed
CA9288962 rs752571527	33	E>Q		No	ClinGen ExAC gnomAD
rs762735105 CA9288963	34	K>E		No	ClinGen ExAC TOPMed gnomAD
rs764034313 CA404723456	34	K>N		No	ClinGen ExAC TOPMed gnomAD
CA404723475 rs1265701637	35	Y>*		No	ClinGen gnomAD
CA404723477 rs1465814039	36	V>M		No	ClinGen gnomAD
rs1183354350 CA404723486	37	G>E		No	ClinGen gnomAD
CA404723485 rs1482174917	37	G>R		No	ClinGen gnomAD
CA306073552 rs17850035	38	A>D		No	ClinGen gnomAD
CA306073555 rs17850035	38	A>V		No	ClinGen gnomAD
rs1414314879 CA404723505	40	E>D		No	ClinGen gnomAD
CA404723507 rs529743191	41	D>H		No	ClinGen 1000Genomes ExAC gnomAD
rs529743191 CA9288986	41	D>N		No	ClinGen 1000Genomes ExAC gnomAD
rs1175672099 CA404723517	42	M>T		No	ClinGen TOPMed gnomAD
rs1450707447 CA404723526	43	L>F		No	ClinGen gnomAD
CA9288987 rs766973453	43	L>S		No	ClinGen ExAC TOPMed gnomAD
CA9288988 rs766973453	43	L>W		No	ClinGen ExAC TOPMed gnomAD
rs1303785779 CA404723529	44	Q>*		No	ClinGen gnomAD
CA9288989 rs755663720	45	A>V		No	ClinGen ExAC TOPMed gnomAD
CA9288990 rs550353809	46	L>P		No	ClinGen 1000Genomes ExAC gnomAD
rs753499096 CA9288991	48	V>A		No	ClinGen ExAC gnomAD
rs1330639990 CA404723552	48	V>I		No	ClinGen gnomAD
CA404723561 rs1310057560	49	H>R		No	ClinGen gnomAD
CA9288993 rs779464879	50	A>P		No	ClinGen ExAC TOPMed gnomAD
CA404723566 rs779464879	50	A>S		No	ClinGen ExAC TOPMed gnomAD
rs1303756637 CA404723599	53	P>A		No	ClinGen gnomAD
CA404723602 rs767501711	53	P>L		No	ClinGen ExAC gnomAD
CA9289006 rs767501711	53	P>Q		No	ClinGen ExAC gnomAD
CA404723603 rs1242671679	54	A>T		No	ClinGen TOPMed
CA9289007 rs773077372	56	E>K		No	ClinGen ExAC gnomAD
TCGA novel	57	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404723633 rs1339758824	58	I>S		No	ClinGen TOPMed gnomAD
CA404723632 rs1339758824	58	I>T		No	ClinGen TOPMed gnomAD
CA9289008 rs760225078	59	N>S		No	ClinGen ExAC gnomAD
COSM992716 rs1287593162 CA404723642	60	E>K	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA404723651 rs1453436374	61	Y>H		No	ClinGen gnomAD
rs917350868 CA306073660	62	S>F		No	ClinGen TOPMed
CA404723659 rs1214370030	62	S>P		No	ClinGen gnomAD
rs753503613 CA9289010	63	W>C		No	ClinGen ExAC gnomAD
rs754704380 CA9289011	64	K>Q		No	ClinGen ExAC gnomAD
rs765661835 CA9289012	65	V>M		No	ClinGen ExAC gnomAD
TCGA novel	69	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758921219 CA9289014	73	Q>R		No	ClinGen ExAC gnomAD
rs1413873717 CA404723743	74	A>G		No	ClinGen TOPMed
CA9289017 COSM3285654 rs757329509	75	E>K	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA404723745 rs757329509	75	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA404723758 rs781179471	76	K>N		No	ClinGen ExAC gnomAD
CA404723780 rs1230282973	78	T>I		No	ClinGen gnomAD
CA404723802 rs1461424176	82	E>Q		No	ClinGen TOPMed
rs1599438931 CA404723824	85	L>V		No	ClinGen Ensembl
CA9289039 rs756243762	86	A>D		No	ClinGen ExAC TOPMed gnomAD
CA404723891 rs1258720320	91	A>V		No	ClinGen gnomAD
rs1441769191 CA404723918	94	R>C		No	ClinGen TOPMed gnomAD
rs568588586 CA9289040	94	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1303436526 CA404723929 CA404723931	95	V>L		No	ClinGen TOPMed gnomAD
rs1212962329 CA404723946	96	P>R		No	ClinGen TOPMed
CA404723958 rs1465235111	97	T>I		No	ClinGen gnomAD
CA306073721 rs767863073	100	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs746929033 CA9289044	101	E>V		No	ClinGen ExAC gnomAD
rs1307399427 CA404724018	102	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA404724034 rs1348548793	104	P>S		No	ClinGen gnomAD
CA9289046 rs776227898	105	A>T		No	ClinGen ExAC TOPMed gnomAD
rs775252175 CA404724082	108	T>M		No	ClinGen ExAC gnomAD
rs775252175 CA9289050	108	T>R		No	ClinGen ExAC gnomAD
TCGA novel	111	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs764471583 CA9289052	112	Q>*		No	ClinGen ExAC gnomAD
rs751872377 CA9289053	112	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA9289055 rs767997949	113	S>*		No	ClinGen ExAC TOPMed gnomAD
CA9289056 rs202069031	114	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA404724148 rs1401582558	114	R>W		No	ClinGen TOPMed
CA9289057 rs373164359	115	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA404724177 rs1215155688	117	Y>C		No	ClinGen gnomAD
rs1419328190 CA404724185	118	T>N		No	ClinGen TOPMed
rs1167722910 CA404724220	120	E>G		No	ClinGen gnomAD
rs950107502 CA306073750	120	E>K		No	ClinGen TOPMed
CA9289060 rs755183433	121	M>I		No	ClinGen ExAC gnomAD
CA404724241 rs1193042562	121	M>K		No	ClinGen TOPMed
CA404724228 rs1463475672	121	M>L		No	ClinGen gnomAD
CA404724251 rs1385120913	122	R>Q		No	ClinGen TOPMed gnomAD
CA9289061 rs777560986	122	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1303741424 CA404724286	123	S>R		No	ClinGen gnomAD
rs1371985009 CA404724335	126	L>P		No	ClinGen gnomAD
rs1371985009 CA404724338	126	L>R		No	ClinGen gnomAD
rs746795479 CA9289062	127	G>D		No	ClinGen ExAC TOPMed gnomAD
CA9289063 rs770820768	128	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1006849955 CA306074376	130	S>F		No	ClinGen Ensembl
rs748733005 CA9289085	130	S>P		No	ClinGen ExAC gnomAD
rs1438516047 CA404725824	133	P>S		No	ClinGen gnomAD
rs747362750 CA9289109	134	E>D		No	ClinGen ExAC gnomAD
rs922711774 CA306074900	134	E>G		No	ClinGen Ensembl
rs1220908807 CA404725841	134	E>Q		No	ClinGen gnomAD
CA404725880 rs1194435344	135	M>I		No	ClinGen gnomAD
CA404725876 rs1469993619	135	M>T		No	ClinGen TOPMed gnomAD
CA306074910 rs201970716	136	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs199750431 CA9289111	137	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1170187802 CA404726030	140	R>S		No	ClinGen gnomAD
CA306074924 rs866085265 COSM3403912	141	T>I	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA9289146 rs375294030	142	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA9289145 rs751164837	142	G>R		No	ClinGen ExAC gnomAD
rs1451188885 CA404726919	143	V>G		No	ClinGen gnomAD
rs1410492239 CA404726910	143	V>M		No	ClinGen TOPMed gnomAD
CA9289147 rs781345842	144	A>E		No	ClinGen ExAC gnomAD
CA404726953 rs1367269309	145	G>E		No	ClinGen TOPMed
rs201210102 CA9289148	146	S>A		No	ClinGen ExAC gnomAD
rs780675472 CA9289150	146	S>C		No	ClinGen ExAC gnomAD
rs201210102 CA9289149	146	S>P		No	ClinGen ExAC gnomAD
CA404727035 rs1599441097	149	V>G		No	ClinGen Ensembl
rs1415251429 CA404727091	151	E>D		No	ClinGen gnomAD
CA9289151 rs530644302	151	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9289152 rs530644302	151	E>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs955401687 CA306075367	153	Q>H		No	ClinGen Ensembl
CA404727149 rs414528	154	L>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9289153 rs414528 VAR_021052	154	L>S		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs414528 CA404727165	154	L>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA404727179 rs1486208281	155	A>S		No	ClinGen TOPMed gnomAD
CA404727191 rs1183927807	155	A>V		No	ClinGen TOPMed gnomAD
rs1241487334 CA404727206	156	A>V		No	ClinGen TOPMed gnomAD
rs1599441138 CA404727235	159	D>A		No	ClinGen Ensembl
rs201369767 CA9289157	161	V>I		No	ClinGen ExAC TOPMed gnomAD
CA404727301 rs1485786640	162	L>R		No	ClinGen TOPMed
rs1432927616 CA404727280	162	L>V		No	ClinGen TOPMed gnomAD
CA404727310 rs1486286041	163	Q>R		No	ClinGen gnomAD
CA9289159 rs369884711	164	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA9289161 rs533252104	164	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9289160 rs533252104	164	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs751074910 CA9289162	165	H>P		No	ClinGen ExAC gnomAD
rs546281101 CA9289163	166	Q>H		No	ClinGen 1000Genomes ExAC gnomAD
CA404727372 rs1599441185	166	Q>K		No	ClinGen Ensembl
CA306075395 rs966702326	166	Q>R		No	ClinGen TOPMed
CA404727485 rs372800273	172	L>V		No	ClinGen ESP TOPMed gnomAD
rs1568309832 CA404727495	173	A>P		No	ClinGen Ensembl
rs201641941 CA9289164 COSM992717	173	A>V	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA9289166 rs756477777	174	E>K		No	ClinGen ExAC gnomAD
rs780587693 CA9289167	176	M>T		No	ClinGen ExAC gnomAD
rs749768029 CA9289168	177	L>V		No	ClinGen ExAC gnomAD
rs907341352 CA306075437	178	G>E		No	ClinGen Ensembl
CA306075436 rs960847220	178	G>R		No	ClinGen TOPMed
rs755542705 CA9289169	180	A>V		No	ClinGen ExAC gnomAD
CA9289171 rs768523611	181	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA9289170 rs761697349	181	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1433805996 CA404727649	182	S>R		No	ClinGen TOPMed
CA404727703 rs1364579636	185	T>I		No	ClinGen TOPMed
rs1306098536 CA404727736	186	N>S		No	ClinGen gnomAD
CA306075447 rs767469086	190	A>T		No	ClinGen TOPMed gnomAD
rs78670441 CA9289173	191	Q>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA404727969 rs1467755606	193	V>D		No	ClinGen TOPMed gnomAD
CA404727966 rs1167312960	193	V>I		No	ClinGen TOPMed
rs1426256223 CA404727973	194	I>F		No	ClinGen TOPMed
CA404728052 rs1191311304	197	D>N		No	ClinGen gnomAD
CA404728111 rs1232843737	198	N>I		No	ClinGen gnomAD
rs1254691347 CA404728123	199	Q>E		No	ClinGen gnomAD
TCGA novel	201	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1468797174 CA404728337	202	S>P		No	ClinGen gnomAD
CA9289184 rs750042348	203	H>N		No	ClinGen ExAC gnomAD
CA9289185 rs755753561	203	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs1258148202 CA404728376	203	H>R		No	ClinGen TOPMed
rs1460836916 CA404728485	207	M>T		No	ClinGen TOPMed
rs754265072 CA9289187	207	M>V		No	ClinGen ExAC gnomAD
rs755449439 CA9289188	208	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA306075682 rs141113430	209	D>H		No	ClinGen 1000Genomes
CA306075685 rs866262671	210	Q>*		No	ClinGen Ensembl
CA9289191 rs758485602	212	L>V		No	ClinGen ExAC TOPMed gnomAD
CA306075700 rs15495	213	E>D		No	ClinGen Ensembl
CA404728642 rs1568309969	213	E>K		No	ClinGen Ensembl
COSM1391401 CA9289192 rs201057224	217	T>M	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA306075716 rs386807400	219	S>R		No	ClinGen Ensembl
CA404728770 rs1568309988	220	E>V		No	ClinGen Ensembl
rs771146695 CA9289194	221	R>C		No	ClinGen ExAC TOPMed
COSM438884 CA9289195 rs189793505	221	R>H	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA9289196 rs189793505	221	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs768507747 CA9289197	223	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs774321379 CA9289198	226	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA404728881 rs1230912127	227	Q>H		No	ClinGen gnomAD
CA306075773 rs1043941961	227	Q>K		No	ClinGen TOPMed gnomAD
rs772601515 CA9289201	228	K>E		No	ClinGen ExAC gnomAD
CA9289202 rs200419019	228	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9289203 rs766112448	229	S>P		No	ClinGen ExAC
rs753608737 CA9289204	231	N>S		No	ClinGen ExAC gnomAD
rs759951373 CA9289205	232	W>S		No	ClinGen ExAC gnomAD
rs765749646 CA9289207	236	A>S		No	ClinGen ExAC TOPMed gnomAD
rs753203157 CA9289208	236	A>V		No	ClinGen ExAC TOPMed gnomAD
CA404729011 rs1370220476	237	M>I		No	ClinGen TOPMed
TCGA novel	237	M>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404729006 rs1458457661	237	M>T		No	ClinGen TOPMed
rs758864556 CA9289209	237	M>V		No	ClinGen ExAC TOPMed gnomAD
CA404729020 rs1190145894	238	L>H		No	ClinGen gnomAD
rs202081681 CA9289210	239	I>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA404729032 rs1418734881	239	I>T		No	ClinGen TOPMed gnomAD
CA404729027 rs202081681	239	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs757389318 CA9289212 COSM992720	241	V>I	endometrium Variant assessed as Somatic; 0.0001425 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs781390296 CA9289213	243	F>S		No	ClinGen ExAC TOPMed gnomAD
rs746134858 CA9289214	246	I>M		No	ClinGen ExAC gnomAD
rs1294615946 CA404729129	247	S>G		No	ClinGen gnomAD
TCGA novel	247	S>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs528918393 CA404729146	248	M>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs528918393 CA9289215	248	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9289216 rs778600202	250	L>F		No	ClinGen ExAC TOPMed gnomAD
rs1244618879 CA404729180	251	F>C		No	ClinGen TOPMed
rs1244618879 CA404729179	251	F>S		No	ClinGen TOPMed
CA9289217 rs748047333	253	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA306075868 rs201756687	253	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9289218 rs201756687	253	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA404729229 rs1212862092	256	P>L		No	ClinGen TOPMed gnomAD
rs760256187 CA9289220	256	P>S		No	ClinGen ExAC gnomAD
rs770604212 CA9289221	257	K>E		No	ClinGen ExAC TOPMed gnomAD
CA404729250 rs1480332126	258	L>F		No	ClinGen gnomAD
rs1175750706 CA404729270	259	K>I		No	ClinGen gnomAD
rs1390674807 CA404729281	260	K>L		No	ClinGen TOPMed
rs1568310107 CA920071248	260	K>L		No	ClinGen Ensembl

No associated diseases with Q9NZ43

No regional properties for Q9NZ43

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9NZ43

Functions

		Description
EC Number
Subcellular Localization	Endoplasmic reticulum membrane ; Single-pass type IV membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
SNARE complex	A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25.

1 GO annotations of molecular function

Name	Definition
SNAP receptor activity	Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion.

5 GO annotations of biological process

Name	Definition
lysosomal transport	The directed movement of substances into, out of or within a lysosome.
protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
protein transport	The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG.
secretion by cell	The controlled release of a substance by a cell.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MAASRLELNL	VRLLSRCEAM	AAEKRDPDEW	RLEKYVGALE	DMLQALKVHA	SKPASEVINE
70	80	90	100	110	120
YSWKVDFLKG	MLQAEKLTSS	SEKALANQFL	APGRVPTTAR	ERVPATKTVH	LQSRARYTSE
130	140	150	160	170	180
MRSELLGTDS	AEPEMDVRKR	TGVAGSQPVS	EKQLAAELDL	VLQRHQNLQE	KLAEEMLGLA
190	200	210	220	230	240
RSLKTNTLAA	QSVIKKDNQT	LSHSLKMADQ	NLEKLKTESE	RLEQHTQKSV	NWLLWAMLII
250
VCFIFISMIL	FIRIMPKLK