AiPD: Autoinhibited Protein Database

Q9NWT1

Gene name	PAK1IP1 (PIP1, WDR84)
Protein name	p21-activated protein kinase-interacting protein 1
Names	PAK/PLC-interacting protein 1, hPIP1, PAK1-interacting protein 1, WD repeat-containing protein 84
Species	Homo sapiens (Human)
KEGG Pathway	hsa:55003
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

287-356 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

287-356 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9NWT1

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9NWT1-F1	Predicted				AlphaFoldDB

321 variants for Q9NWT1

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1189481622 CA362712472	3	L>V		No	ClinGen TOPMed
rs763848894 CA3632570	4	V>F		No	ExAC gnomAD ClinGen
rs757088413 CA362712481	5	A>P		No	ExAC TOPMed gnomAD ClinGen
rs757088413 CA3632572	5	A>S		No	ClinGen ExAC TOPMed gnomAD
rs200871118 CA3632573	6	G>C		No	ClinGen ExAC TOPMed gnomAD
rs1361731562 CA362712505 CA362712506	8	Y>*		No	gnomAD ClinGen
CA362712513 rs1182004409	9	E>D		No	ClinGen gnomAD
rs371781516 CA3632574	9	E>K		No	ESP ExAC TOPMed gnomAD ClinGen
rs371781516 CA362712507	9	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs756176747 CA3632575	10	Q>E		No	ClinGen ExAC TOPMed gnomAD
rs376060945 CA134112960	10	Q>H		No	ESP TOPMed ClinGen
CA362712521 rs1299991263	11	V>I		No	ClinGen TOPMed
rs915535382 CA134112969	13	F>C		No	TOPMed gnomAD ClinGen
rs915535382 CA362712534	13	F>S		No	ClinGen TOPMed gnomAD
CA3632576 rs780256684	13	F>V		No	ClinGen ExAC TOPMed gnomAD
CA134112965 rs915535382	13	F>Y		No	ClinGen TOPMed gnomAD
rs1467643460 CA362712542	14	G>V		No	gnomAD ClinGen
CA362712558 rs1171955323	17	V>L		No	gnomAD ClinGen
CA3632577 rs749417108	18	H>Y		No	ClinGen ExAC gnomAD
CA362712581 rs1331835439	20	E>A		No	ClinGen TOPMed gnomAD
rs1341888426 CA362712582	20	E>D		No	ClinGen gnomAD
rs774651899 CA3632579	21	P>L		No	ClinGen ExAC gnomAD
rs1448195071 CA362712585	21	P>S		No	ClinGen gnomAD
rs772493979 CA3632582	22	E>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA3632583 rs761160420	24	C>F		No	ExAC gnomAD ClinGen
TCGA novel	24	C>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA362712618 rs1339009310	26	D>G		No	ClinGen TOPMed
rs1198486289 CA362712615	26	D>N		No	gnomAD ClinGen
TCGA novel rs1008791325 CA134114205	30	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	TOPMed NCI-TCGA ClinGen
CA3632604 rs777145719	31	T>I		No	ClinGen ExAC TOPMed gnomAD
CA362712725 rs777145719	31	T>S		No	ClinGen ExAC TOPMed gnomAD
CA362712737 rs1381378465	33	V>E		No	ClinGen gnomAD
TCGA novel	33	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA362712748 rs1385034760	35	D>G		No	gnomAD ClinGen
CA362712752 rs1325385485	36	F>I		No	gnomAD ClinGen
CA3632605 rs369987329	36	F>L		No	ESP ExAC gnomAD ClinGen
TCGA novel	36	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3632606 rs768207218	38	H>Y		No	ClinGen ExAC gnomAD
rs1027730861 COSM1672234 CA134114235	43	A>T	prostate [Cosmic]	No	Ensembl ClinGen cosmic curated
CA3632610 rs370701797	48	V>I		No	ClinGen ExAC TOPMed gnomAD
rs946134331 CA362712835	49	A>P		No	TOPMed gnomAD ClinGen
rs946134331 CA134114257	49	A>T		No	TOPMed gnomAD ClinGen
rs1437657134 CA362712842	50	V>I		No	ClinGen gnomAD
CA362712857 rs1177158343	52	S>N		No	ClinGen gnomAD
rs1581580007 CA362712862	53	R>C		No	Ensembl ClinGen
CA134114259 rs1041702774	53	R>H		No	TOPMed gnomAD ClinGen
CA362712865 rs1041702774	53	R>P		No	TOPMed gnomAD ClinGen
rs1158757669 CA362712877	55	V>L		No	ClinGen TOPMed
rs1158809032 CA362712882	56	V>L		No	ClinGen gnomAD
TCGA novel	58	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA362712913 rs1183140580	60	K>N		No	TOPMed ClinGen
CA3632613 rs139672454	60	K>R		No	ESP ExAC TOPMed gnomAD ClinGen
rs980796839 CA134114286	62	E>K		No	ClinGen Ensembl
CA3632614 rs1035406624	66	I>V		No	TOPMed gnomAD ClinGen
CA3632617 rs149772832	67	Y>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3632616 rs754942039	67	Y>H		No	ExAC gnomAD ClinGen
rs149772832 CA134114317	67	Y>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs988335577 CA134114324 COSM3941438	68	D>E	oesophagus [Cosmic]	No	TOPMed ClinGen cosmic curated
CA3632618 rs752771472	69	M>I		No	ExAC ClinGen
rs758617036 CA3632619	70	K>R		No	ExAC gnomAD ClinGen
rs1329060208 CA362712987	71	K>R		No	gnomAD ClinGen
CA3632620 rs778004073	73	I>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC gnomAD ClinGen NCI-TCGA
rs1378751120 CA362713012	73	I>T		No	gnomAD ClinGen
rs771299681 CA3632622	75	H>N		No	ExAC TOPMed gnomAD ClinGen
CA3632623 rs781604474	75	H>P		No	ExAC gnomAD ClinGen
TCGA novel	77	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs746373040 CA3632624	78	L>V		No	ExAC gnomAD ClinGen
rs770251781 CA3632625	79	V>A		No	ExAC gnomAD ClinGen
rs1339292795 CA362713095	79	V>M		No	ClinGen gnomAD
rs773879151 CA3632626	80	H>P		No	ClinGen ExAC gnomAD
rs773879151 CA3632627	80	H>R		No	ClinGen ExAC gnomAD
CA362713122 rs1458453525	81	H>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	gnomAD ClinGen NCI-TCGA
rs751776397 CA3632638	84	T>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC gnomAD ClinGen NCI-TCGA
CA3632639 rs757532852	84	T>I		No	ClinGen ExAC gnomAD
rs1256283696 CA362707430	85	I>V		No	gnomAD ClinGen
rs998869219 CA134083836	86	T>I		No	TOPMed gnomAD ClinGen
TCGA novel	89	K>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	90	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs756602288 CA362707505	91	Y>*		No	ExAC TOPMed gnomAD ClinGen
CA3632641 rs746255966	91	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA134083848 rs576643867	91	Y>H		No	Ensembl ClinGen
CA362707514 rs1486906066	92	G>D		No	ClinGen TOPMed
rs1478065056 CA362707549	95	H>L		No	TOPMed gnomAD ClinGen
CA362707550 rs1478065056	95	H>R		No	ClinGen TOPMed gnomAD
rs1209913480 CA362707561	96	L>F		No	ClinGen gnomAD
CA362707571 rs1487800692	97	I>N		No	TOPMed ClinGen
CA134083863 rs200414486	98	S>T		No	Ensembl ClinGen
rs543079611 CA3632643	100	A>V		No	ClinGen 1000Genomes ExAC gnomAD
CA134083872 rs989015642	101	E>G		No	Ensembl ClinGen
rs576346939 CA3632645	104	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1456160523 CA362707651	104	L>P		No	ClinGen gnomAD
rs1409725885 CA362707668	106	C>R		No	Ensembl ClinGen
CA362707720 rs1398190019	109	D>A		No	ClinGen TOPMed gnomAD
rs1360031821 CA362707717	109	D>N		No	gnomAD ClinGen
CA362707724 rs1398190019	109	D>V		No	TOPMed gnomAD ClinGen
rs1280719286 CA362707738	110	A>V		No	ClinGen gnomAD
CA362707759 rs1341663907	112	K>Q		No	ClinGen gnomAD
CA362707801 rs1226070786	113	W>L		No	ClinGen TOPMed
rs1306756683 CA362707783	113	W>R		No	Ensembl ClinGen
CA134083883 rs954230160	114	E>K		No	TOPMed gnomAD ClinGen
rs770759731 CA3632648	115	C>S		No	ExAC gnomAD ClinGen
rs759283569 CA3632650	116	L>P		No	ClinGen ExAC TOPMed gnomAD
rs775304872 CA3632652	118	S>A		No	ClinGen ExAC TOPMed gnomAD
rs1305319312 CA362707938	120	K>N		No	TOPMed ClinGen
rs1213806151 CA362707947	121	A>V		No	ClinGen gnomAD
CA134083911 rs933583838	122	H>P		No	ClinGen TOPMed
rs775412822 CA3632670	123	K>N		No	ExAC gnomAD ClinGen
rs62621438 CA3632671	124	G>R		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
rs551247280 CA3632672	126	V>L		No	ExAC TOPMed gnomAD ClinGen
CA3632675 rs200433932	129	L>F		No	ClinGen 1000Genomes ExAC gnomAD
CA362708146 rs548226729	132	H>Q		No	1000Genomes ExAC gnomAD ClinGen
rs569689711 CA3632678	133	P>A		No	1000Genomes ExAC TOPMed gnomAD ClinGen
CA3632679 rs754307959	133	P>L		No	ClinGen ExAC gnomAD
rs569689711 CA3632677	133	P>S		No	1000Genomes ExAC TOPMed gnomAD ClinGen
rs1444149658 CA362708185	134	S>C		No	ClinGen gnomAD
CA362708189 rs1310941584	135	G>S		No	gnomAD ClinGen
CA3632680 rs755512237	137	L>V		No	ExAC ClinGen
rs1048882804 CA134084051	138	A>T		No	TOPMed ClinGen
CA362708260 rs1463974352	138	A>V		No	TOPMed ClinGen
rs1277010938 CA362708276	139	L>P		No	ClinGen gnomAD
CA362708289 rs1350809622	140	S>L		No	gnomAD ClinGen
CA134084069 rs141357694	141	V>A		No	ESP TOPMed gnomAD ClinGen
rs751066241 CA3632682	141	V>I		No	ExAC gnomAD ClinGen
TCGA novel	142	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3632684 rs780830226	143	T>K		No	ClinGen ExAC TOPMed gnomAD
rs1037020277 CA134084074	144	D>G		No	TOPMed ClinGen
rs1258335016 CA362708376	146	T>A		No	ClinGen TOPMed gnomAD
CA134084086 rs1035617206	147	L>S		No	ClinGen Ensembl
rs753133647 CA3632697	149	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1226158270 CA362708606	152	L>P		No	ClinGen TOPMed
rs972279400 CA134084628	153	V>I		No	ClinGen TOPMed gnomAD
rs972279400 CA362708621	153	V>L		No	ClinGen TOPMed gnomAD
CA3632703 rs765782849	156	R>G		No	ExAC gnomAD ClinGen
CA362708664 rs753261456	156	R>I		No	ExAC TOPMed gnomAD ClinGen
CA3632704 rs753261456	156	R>K		No	ClinGen ExAC TOPMed gnomAD
rs1401875316 CA362708713	160	I>V		No	gnomAD ClinGen
CA362708727 rs1581583992	161	K>E		No	ClinGen Ensembl
rs559977553 CA3632706	161	K>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	162	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3632707 rs530364577	162	N>T		No	ClinGen 1000Genomes ExAC gnomAD
CA362708738 rs1338913716	162	N>Y		No	ClinGen TOPMed
rs1305414182 CA362708756	164	K>E		No	TOPMed ClinGen
rs1360431859 CA362708766	164	K>N		No	ClinGen gnomAD
CA362708770 rs1414843182	165	Q>E		No	gnomAD ClinGen
rs764693083 CA3632723	167	A>S		No	ClinGen ExAC gnomAD
CA362709225 rs1318841475	168	H>R		No	ClinGen gnomAD
rs1230758231 CA362709239	169	I>M		No	gnomAD ClinGen
rs749851403 CA3632724	169	I>T		No	ClinGen ExAC gnomAD
CA362709232 rs1406046644	169	I>V		No	ClinGen TOPMed
CA134085303 rs938084538	170	V>E		No	gnomAD ClinGen
rs1239627967 CA362709265	172	W>*		No	ClinGen gnomAD
CA3632725 rs201862329	172	W>C		No	ClinGen ExAC gnomAD
CA362709261 rs1348879251	172	W>R		No	gnomAD ClinGen
CA3632726 rs765946190	173	S>T		No	ClinGen ExAC gnomAD
CA3632727 rs753482373	174	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	174	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	175	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3632729 rs778660768	176	G>E		No	ClinGen ExAC TOPMed gnomAD
CA3632728 rs754679174 CA362709308	176	G>R		No	ClinGen ExAC TOPMed gnomAD
rs748018921 CA3632730	177	E>D		No	ExAC TOPMed gnomAD ClinGen
CA362709336 rs1454457308	179	Y>H		No	gnomAD ClinGen
TCGA novel	180	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs375444258 CA3632731	180	V>L		No	ESP ExAC TOPMed gnomAD ClinGen
CA362709356 rs1581584807	181	V>I		No	ClinGen Ensembl
CA134085341 rs770529700	182	I>T		No	gnomAD ClinGen
CA134085344 rs916074390	183	I>M		No	ClinGen TOPMed
rs771049452 CA3632735	184	Q>*		No	ClinGen ExAC gnomAD
CA3632739 rs775957449	189	I>M		No	ClinGen ExAC TOPMed gnomAD
CA3632738 rs141123017	189	I>T		No	ClinGen 1000Genomes ExAC gnomAD
rs201625393 CA3632737	189	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA3632743 rs762291816	190	Y>C		No	ExAC TOPMed gnomAD ClinGen
CA3632742 rs764449402	190	Y>H		No	ExAC TOPMed gnomAD ClinGen
CA3632741 rs764449402	190	Y>N		No	ClinGen ExAC TOPMed gnomAD
rs1261693949 CA362709510	194	T>I		No	gnomAD ClinGen
CA134085369 rs929059408	195	A>V		No	ClinGen TOPMed gnomAD
CA3632744 rs765857722	196	S>P		No	ExAC gnomAD ClinGen
rs145305623 CA134085378	198	S>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs145305623 CA3632745	198	S>N		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
CA3632746 rs754597395	200	T>I		No	ClinGen ExAC TOPMed gnomAD
CA362709594 rs1427729335	201	I>M		No	ClinGen TOPMed
rs1177665734 CA362709586	201	I>T		No	ClinGen gnomAD
rs17856340 CA134085402	201	I>V		No	Ensembl ClinGen
TCGA novel	204	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	206	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1268338228 CA362709675	207	I>M		No	ClinGen TOPMed gnomAD
rs1235951252 CA362709667	207	I>N		No	gnomAD ClinGen
CA3632748 rs374642668	208	S>F		No	ESP ExAC TOPMed gnomAD ClinGen
rs1456355850 COSM1071797 CA362709733	213	L>I	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA134085409 rs1001055212	213	L>P		No	ClinGen Ensembl
CA134085529 rs112971132	215	E>D		No	ClinGen TOPMed
CA3632766 rs759073628	215	E>G		No	ExAC gnomAD ClinGen
rs1462708228 CA362709779	215	E>K		No	gnomAD ClinGen
rs1042628376 CA134085536	220	V>M		No	TOPMed ClinGen
rs1340442424 CA362709851	223	D>E		No	ClinGen gnomAD
CA3632769 rs762579782	223	D>G		No	ClinGen ExAC gnomAD
CA134085539 rs903255182	225	E>V		No	ClinGen TOPMed gnomAD
rs1581585109 CA362709871	226	V>G		No	ClinGen Ensembl
rs1019064119 CA134085558	226	V>I		No	ClinGen Ensembl
CA134085570 rs751362115	227	I>K		No	ExAC TOPMed gnomAD ClinGen
rs751362115 CA3632771	227	I>T		No	ExAC TOPMed gnomAD ClinGen
CA362709886 rs1581585124	229	F>V		No	Ensembl ClinGen
TCGA novel	230	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM3429824 CA362709899 rs1248330092	230	F>L	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
CA3632772 rs757218948	231	D>V		No	ClinGen ExAC gnomAD
CA362709902 rs1227761972	231	D>Y		No	ClinGen gnomAD
rs1482023186 CA362709908	232	C>R		No	TOPMed gnomAD ClinGen
CA3632773 rs781299034	232	C>Y		No	ExAC gnomAD ClinGen
CA134085591 rs1035653928	233	D>N		No	TOPMed ClinGen
CA3632775 rs756266685	235	L>P		No	ExAC TOPMed gnomAD ClinGen
CA134085606 rs960066635	235	L>V		No	TOPMed ClinGen
rs780060997 CA3632776	236	V>A		No	ExAC gnomAD ClinGen
rs1479490155 CA362709939	237	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	TOPMed ClinGen NCI-TCGA
rs1211316676 CA362709945	238	L>F		No	TOPMed ClinGen
rs1175682038 COSM1439566 CA362709957	240	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA3632778 rs768806860	242	K>R		No	ExAC gnomAD ClinGen
CA362709985 rs1436731359	243	A>V		No	ClinGen gnomAD
TCGA novel	245	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA134085624 rs768386985	247	R>K		No	Ensembl ClinGen
CA362710091 rs1389597755	248	V>L		No	TOPMed ClinGen
rs970831289 CA134087229	255	E>V		No	TOPMed ClinGen
CA3632796 rs780155614	257	P>A		No	ExAC TOPMed gnomAD ClinGen
CA3632797 rs780155614	257	P>S		No	ClinGen ExAC TOPMed gnomAD
rs774340999 CA3632798	259	H>R		No	ExAC TOPMed gnomAD ClinGen
CA362710266 rs1317445830	259	H>Y		No	TOPMed gnomAD ClinGen
rs926366590 CA134087240	260	H>Y		No	TOPMed gnomAD ClinGen
CA362710299 rs1469627432	261	V>L		No	gnomAD ClinGen
CA3632799 rs779029025	265	A>V		No	ClinGen ExAC gnomAD
CA3632802 rs778178362	267	S>N		No	ExAC gnomAD ClinGen
rs1179031663 CA362710417	272	K>R		No	ClinGen gnomAD
CA3632803 rs747502007	273	M>I		No	ClinGen ExAC gnomAD
rs771392427 CA3632804	275	K>T		No	ExAC ClinGen
rs777647099 CA134087270	276	L>F		No	Ensembl ClinGen
CA134087274 rs17850695	277	K>E		No	Ensembl ClinGen
CA3632807 rs748769773	279	D>G		No	ClinGen ExAC gnomAD
rs748769773 CA362710512	279	D>V		No	ClinGen ExAC gnomAD
CA134087288 rs956362330	279	D>Y		No	Ensembl ClinGen
rs543748909 CA3632808	280	K>E		No	ClinGen 1000Genomes ExAC gnomAD
rs1330440499 CA362710788	281	K>Q		No	ClinGen gnomAD
CA3632828 rs774061851	281	K>R		No	ClinGen ExAC gnomAD
rs150098092 CA3632829	282	V>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA362710803 rs1446641274	282	V>I		No	ClinGen TOPMed gnomAD
CA134088352 rs988724197	284	P>S		No	ClinGen TOPMed
rs1331616971 CA362710843	286	L>I		No	TOPMed ClinGen
CA362710846 rs1301929326	286	L>S		No	TOPMed ClinGen
CA3632830 rs771887841	287	L>F		No	ClinGen ExAC gnomAD
rs1422201546 CA362710852	287	L>P		No	TOPMed ClinGen
rs1371940259 CA362710855	288	C>S		No	ClinGen TOPMed
CA362710868 rs1233762706	289	E>A		No	ClinGen gnomAD
CA362710877 rs1168805160	290	I>M		No	TOPMed ClinGen
CA134088355 rs947557583	292	T>I		No	ClinGen Ensembl
rs1409058274 CA362710888	292	T>S		No	ClinGen TOPMed
rs866669053 CA134088356	293	N>I		No	Ensembl ClinGen
CA362710903 rs1193312289	294	A>V		No	TOPMed ClinGen
rs759587941 CA3632835	297	T>M		No	ClinGen ExAC gnomAD
rs759587941 CA362710920	297	T>R		No	ClinGen ExAC gnomAD
rs541330686 CA3632837	299	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1484061175 CA362710982	307	A>T		No	ClinGen TOPMed
CA362710986 rs1193510970	307	A>V		No	ClinGen gnomAD
rs764331618 CA3632840	309	M>V		No	ClinGen ExAC gnomAD
rs971167647 CA134088433	311	E>K		No	TOPMed ClinGen
CA134088446 rs11541087	313	L>P		No	Ensembl ClinGen
TCGA novel	314	P>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751862442 CA3632841	314	P>S		No	ClinGen ExAC gnomAD
rs757564742 CA3632842	315	P>L		No	ExAC gnomAD ClinGen
TCGA novel	320	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781668945 CA3632844	321	P>S		No	ClinGen ExAC gnomAD
rs762152013 CA3632860	325	E>V		No	ClinGen ExAC gnomAD
CA3632862 rs750835827	327	S>F		No	ClinGen ExAC gnomAD
rs370741204 CA3632861	327	S>P		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	329	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	332	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3632864 rs201629252	333	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA362711196 rs1441369764	335	G>S		No	ClinGen gnomAD
rs375199458 CA3632867	338	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs757989245 CA3632866	338	V>M		No	ExAC gnomAD ClinGen
CA3632869 rs770667105	340	K>E		No	ExAC TOPMed gnomAD ClinGen
CA3632871 rs745708831	342	E>A		No	ClinGen ExAC gnomAD
rs149331925 CA3632870	342	E>Q		No	ESP ExAC TOPMed gnomAD ClinGen
rs190974202 CA3632873	344	R>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	1000Genomes ExAC TOPMed gnomAD ClinGen NCI-TCGA
rs190974202 CA3632874	344	R>Q		No	1000Genomes ExAC TOPMed gnomAD ClinGen
COSM1071803 CA3632872 rs769673112	344	R>W	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA3632876 rs774539405	345	S>P		No	ExAC gnomAD ClinGen
rs1352705212 CA362711317	348	N>H		No	ClinGen Ensembl
CA3632877 rs761905760	350	K>E		No	ClinGen ExAC gnomAD
rs1417396834 CA362711359	351	K>E		No	TOPMed ClinGen
CA3632878 rs147437498 COSM1439573	352	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA3632879 rs750701531	352	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs532654988 CA362711387	353	G>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3632880 rs532654988	353	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3632882 rs548071451	355	T>R		No	1000Genomes ExAC gnomAD ClinGen
rs138082481 CA3632881	355	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA362711458 rs1468653869	357	D>H		No	ClinGen TOPMed gnomAD
CA362711454 rs1468653869	357	D>Y		No	TOPMed gnomAD ClinGen
CA3632884 rs763494608	358	S>G		No	ExAC TOPMed gnomAD ClinGen
CA3632885 rs34857240	359	K>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3632887 rs147259600	362	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1381592765 CA362711597	362	T>I		No	TOPMed ClinGen
TCGA novel	364	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1561895989 CA362711661	366	G>S		No	ClinGen Ensembl
rs768619766 CA3632892	368	I>M		No	ClinGen ExAC gnomAD
rs1437708870 CA362711704	368	I>T		No	ClinGen TOPMed
rs749199819 CA3632891	368	I>V		No	ExAC gnomAD ClinGen
rs201265248 CA3632893	369	S>P		No	ClinGen ExAC gnomAD
CA362711760 rs1296638087	372	K>R		No	ClinGen gnomAD
rs72821574 CA3632894	376	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs150834153 CA3632895	378	M>I		No	ESP ExAC TOPMed gnomAD ClinGen
CA134088835 rs747636201	384	K>E		No	ClinGen TOPMed gnomAD
rs1383628115 CA362711927	384	K>R		No	TOPMed ClinGen
TCGA novel	385	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3632897 rs139264536	386	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA134088874 rs995826338	388	I>M		No	TOPMed ClinGen
rs537437372 CA3632898	388	I>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1340931492 CA362711996	389	K>R		No	ClinGen gnomAD
CA362712006 rs1195879678	390	T>A		No	ClinGen gnomAD
rs764243590 CA3632899	390	T>I		No	ClinGen ExAC TOPMed gnomAD
rs764243590 CA3632900	390	T>K		No	ClinGen ExAC TOPMed gnomAD
CA362712024 rs1484665335	391	M>R		No	ClinGen gnomAD
rs1561896081 CA362712019	391	M>V		No	ClinGen Ensembl
CA3632902 rs760088755	392	Q>*		No	ExAC gnomAD ClinGen
CA3632903 rs765805578	392	Q>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA3632904 rs750985706	393	Q>S		No	ClinGen ExAC

No associated diseases with Q9NWT1

8 regional properties for Q9NWT1

Type	Name	Position	InterPro Accession
repeat	WD40 repeat	29 - 70	IPR001680-1
repeat	WD40 repeat	71 - 160	IPR001680-2
repeat	WD40 repeat	194 - 231	IPR001680-3
repeat	WD40 repeat	234 - 284	IPR001680-4
conserved_site	WD40 repeat, conserved site	138 - 152	IPR019775
repeat	G-protein beta WD-40 repeat	96 - 110	IPR020472-1
repeat	G-protein beta WD-40 repeat	138 - 152	IPR020472-2
repeat	G-protein beta WD-40 repeat	262 - 276	IPR020472-3

Functions

		Description
EC Number
Subcellular Localization	Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

5 GO annotations of biological process

Name	Definition
cell population proliferation	The multiplication or reproduction of cells, resulting in the expansion of a cell population.
negative regulation of signal transduction	Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.
regulation of signal transduction by p53 class mediator	Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator.
ribosomal large subunit biogenesis	A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.
roof of mouth development	The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MELVAGCYEQ	VLFGFAVHPE	PEACGDHEQW	TLVADFTHHA	HTASLSAVAV	NSRFVVTGSK
70	80	90	100	110	120
DETIHIYDMK	KKIEHGALVH	HSGTITCLKF	YGNRHLISGA	EDGLICIWDA	KKWECLKSIK
130	140	150	160	170	180
AHKGQVTFLS	IHPSGKLALS	VGTDKTLRTW	NLVEGRSAFI	KNIKQNAHIV	EWSPRGEQYV
190	200	210	220	230	240
VIIQNKIDIY	QLDTASISGT	ITNEKRISSV	KFLSESVLAV	AGDEEVIRFF	DCDSLVCLCE
250	260	270	280	290	300
FKAHENRVKD	MFSFEIPEHH	VIVSASSDGF	IKMWKLKQDK	KVPPSLLCEI	NTNARLTCLG
310	320	330	340	350	360
VWLDKVADMK	ESLPPAAEPS	PVSKEQSKIG	KKEPGDTVHK	EEKRSKPNTK	KRGLTGDSKK
370	380	390
ATKESGLIST	KKRKMVEMLE	KKRKKKKIKT	MQ