Q9NVU0
PR
Gene name |
POLR3E (KIAA1452) |
Protein name |
DNA-directed RNA polymerase III subunit RPC5 |
Names |
RNA polymerase III subunit C5, DNA-directed RNA polymerase III 80 kDa polypeptide |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:55718 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
17 structures for Q9NVU0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 7A6H | EM | 330 A | M | 1-708 | PDB |
| 7AE1 | EM | 280 A | M | 1-708 | PDB |
| 7AE3 | EM | 310 A | M | 1-708 | PDB |
| 7AEA | EM | 340 A | M | 1-708 | PDB |
| 7AST | EM | 400 A | K | 1-708 | PDB |
| 7ASU | X-ray | 223 A | A | 1-708 | PDB |
| 7ASV | X-ray | 155 A | A/B | 1-708 | PDB |
| 7D58 | EM | 290 A | M | 1-708 | PDB |
| 7D59 | EM | 310 A | M | 1-708 | PDB |
| 7DN3 | EM | 350 A | M | 1-708 | PDB |
| 7DU2 | EM | 335 A | M | 1-708 | PDB |
| 7FJI | EM | 360 A | M | 1-708 | PDB |
| 7FJJ | EM | 360 A | M | 1-708 | PDB |
| 8ITY | EM | 390 A | M | 1-708 | PDB |
| 8IUE | EM | 410 A | M | 1-708 | PDB |
| 8IUH | EM | 340 A | M | 1-708 | PDB |
| AF-Q9NVU0-F1 | Predicted | AlphaFoldDB |
592 variants for Q9NVU0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA395094076 rs1482582189 |
2 | A>D | No |
ClinGen gnomAD |
|
|
rs1452546462 CA395094132 |
4 | E>D | No |
TOPMed ClinGen |
|
|
rs375024210 CA7956445 |
6 | D>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA395094286 rs1598233456 |
9 | V>G | No |
Ensembl ClinGen |
|
|
CA395094272 rs1257015292 |
9 | V>I | No |
ClinGen gnomAD |
|
|
rs1256165050 CA395094351 |
12 | E>K | No |
ClinGen TOPMed |
|
|
CA279454796 rs775635945 |
13 | I>L | No |
Ensembl ClinGen |
|
|
CA395095119 rs867943604 |
13 | I>M | No |
ClinGen TOPMed |
|
|
rs752717152 CA7956480 |
14 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs767608665 CA7956479 |
14 | D>G | No |
ClinGen ExAC gnomAD |
|
|
CA279454805 rs927369976 |
14 | D>N | No |
TOPMed ClinGen |
|
|
CA279454810 rs1057436343 |
15 | V>M | No |
ClinGen Ensembl |
|
|
CA7956481 rs756333804 |
16 | Y>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs777971329 CA7956482 |
18 | A>S | No |
ExAC gnomAD ClinGen |
|
|
CA395095146 rs1350484131 |
18 | A>V | No |
TOPMed ClinGen |
|
|
CA7956483 rs754217445 |
19 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA279454823 rs762076428 |
20 | S>N | No |
ClinGen gnomAD |
|
|
rs990064582 CA279454830 |
21 | L>P | No |
TOPMed ClinGen |
|
|
CA7956485 rs779326078 |
22 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ExAC TOPMed gnomAD ClinGen NCI-TCGA |
|
rs1598237736 CA395095176 |
23 | E>G | No |
ClinGen Ensembl |
|
|
rs1161320179 CA395095198 |
26 | Y>C | No |
ClinGen gnomAD |
|
|
rs890880013 CA279454861 |
27 | L>V | No |
ClinGen TOPMed |
|
|
rs763126619 CA279454876 |
29 | Q>H | No |
Ensembl ClinGen |
|
|
CA7956522 rs371107234 |
33 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ESP ExAC gnomAD ClinGen NCI-TCGA |
|
rs1197228508 CA395095384 |
33 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
gnomAD ClinGen NCI-TCGA |
|
rs1478668526 CA395095402 |
35 | A>T | No |
ClinGen gnomAD |
|
|
rs1409926936 CA395095423 |
36 | S>L | No |
gnomAD ClinGen |
|
|
CA7956524 rs767041060 |
36 | S>P | No |
ClinGen ExAC gnomAD |
|
|
CA395095470 rs1387428173 |
39 | Y>C | No |
ClinGen gnomAD |
|
|
CA7956528 rs200525630 |
40 | D>H | No |
1000Genomes ESP ExAC TOPMed gnomAD ClinGen |
|
|
CA7956529 rs200525630 |
40 | D>N | No |
1000Genomes ESP ExAC TOPMed gnomAD ClinGen |
|
| TCGA novel | 41 | D>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA395095542 rs1406747422 |
43 | P>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
gnomAD ClinGen NCI-TCGA |
|
CA395095553 rs1219044860 |
44 | H>Y | No |
TOPMed ClinGen |
|
|
rs778642427 CA7956533 |
45 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs2347 VAR_024623 CA7956534 |
46 | S>A | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs200294154 CA7956535 |
46 | S>L | No |
1000Genomes ExAC TOPMed gnomAD ClinGen |
|
|
rs2347 CA279457249 |
46 | S>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA7956537 rs761791108 |
52 | K>E | No |
ExAC gnomAD ClinGen |
|
|
rs200324185 CA279457270 |
53 | Q>K | No |
TOPMed gnomAD ClinGen |
|
|
rs748308867 CA7956555 |
56 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA279457790 rs748308867 |
56 | V>L | No |
ExAC TOPMed gnomAD ClinGen |
|
| TCGA novel | 57 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA395095864 rs1567312051 |
58 | L>F | No |
ClinGen Ensembl |
|
|
CA395095893 rs1567312063 |
59 | E>D | No |
ClinGen Ensembl |
|
|
rs1323570972 CA395095928 |
62 | I>T | No |
Ensembl ClinGen |
|
|
CA395095924 rs1166517993 |
62 | I>V | No |
ClinGen gnomAD |
|
|
rs1430389859 CA395095931 |
63 | D>N | No |
TOPMed gnomAD ClinGen |
|
|
CA395095949 rs1264320378 |
65 | L>P | No |
ClinGen gnomAD |
|
|
CA279457804 rs368180184 |
67 | P>R | No |
ESP gnomAD ClinGen |
|
|
CA395095960 rs1399522285 |
67 | P>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA395095974 rs1334335667 |
69 | Y>C | No |
TOPMed gnomAD ClinGen |
|
|
CA279457806 rs547486392 |
69 | Y>D | No |
1000Genomes ClinGen |
|
|
CA7956557 rs370651948 |
71 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA395095987 rs370651948 |
71 | R>G | No |
1000Genomes ESP ExAC TOPMed gnomAD ClinGen |
|
|
rs145630346 CA7956558 COSM1197255 |
71 | R>H | lung [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD |
|
CA395095988 rs145630346 |
71 | R>L | No |
1000Genomes ExAC TOPMed gnomAD ClinGen |
|
|
CA395095986 rs370651948 |
71 | R>S | No |
1000Genomes ESP ExAC TOPMed gnomAD ClinGen |
|
|
CA279457826 rs777396767 |
72 | S>C | No |
ClinGen Ensembl |
|
|
CA395095992 rs1295913616 |
72 | S>N | No |
ClinGen gnomAD |
|
|
rs771213501 CA7956559 |
72 | S>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1295913616 CA395095993 |
72 | S>T | No |
gnomAD ClinGen |
|
|
CA7956560 rs774923031 |
73 | K>E | No |
ExAC gnomAD ClinGen |
|
|
rs759806703 CA7956561 |
75 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs759806703 CA395096009 |
75 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
rs753118768 CA7956563 |
78 | A>V | No |
ExAC TOPMed gnomAD ClinGen |
|
|
CA395096039 rs1462856653 |
79 | L>P | No |
TOPMed gnomAD ClinGen |
|
|
CA7956567 rs374276149 |
81 | V>L | No |
ESP ExAC TOPMed gnomAD ClinGen |
|
|
rs374276149 CA7956566 |
81 | V>M | No |
ESP ExAC TOPMed gnomAD ClinGen |
|
|
rs369770126 CA7956569 |
83 | G>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA395096081 rs1465063735 |
86 | A>T | No |
TOPMed gnomAD ClinGen |
|
|
CA7956573 rs754893391 |
87 | D>G | No |
ClinGen ExAC gnomAD |
|
|
rs746948766 CA7956572 |
87 | D>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ExAC TOPMed gnomAD ClinGen NCI-TCGA |
|
rs749376430 CA7956575 |
88 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA279457889 rs1030807383 |
90 | S>N | No |
TOPMed ClinGen |
|
|
rs771336397 CA7956576 |
91 | T>M | No |
ExAC TOPMed gnomAD ClinGen |
|
|
rs557391772 CA7956579 |
92 | Y>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA7956580 rs775877140 |
94 | S>L | No |
ClinGen ExAC gnomAD |
|
|
CA395096410 rs1471297254 |
97 | M>L | No |
gnomAD ClinGen |
|
|
CA279458287 rs993189073 |
100 | Q>H | No |
ClinGen TOPMed |
|
|
CA7956601 rs374559993 |
100 | Q>R | No |
ESP ExAC TOPMed gnomAD ClinGen |
|
| TCGA novel | 102 | F>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 104 | S>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1226174419 CA395096470 |
105 | S>Y | No |
gnomAD ClinGen |
|
|
rs1164336248 CA395096474 |
106 | Q>E | No |
TOPMed ClinGen |
|
|
CA395096492 rs1272054545 |
108 | T>I | No |
TOPMed gnomAD ClinGen |
|
|
CA7956603 rs772727182 |
110 | N>K | No |
ExAC gnomAD ClinGen |
|
|
rs1348574377 CA395096509 |
111 | T>A | No |
ClinGen gnomAD |
|
|
rs201393769 CA7956604 |
113 | R>C | No |
1000Genomes ESP ExAC TOPMed gnomAD ClinGen |
|
|
CA395096522 rs1181577668 |
113 | R>H | No |
TOPMed ClinGen |
|
|
rs1304225668 CA395096526 |
114 | Y>H | No |
ClinGen gnomAD |
|
|
CA7956607 rs376659970 |
116 | A>S | No |
ESP ExAC TOPMed gnomAD ClinGen |
|
|
CA7956606 rs376659970 |
116 | A>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs71378445 CA279458333 |
116 | A>V | No |
ClinGen Ensembl |
|
|
CA279458357 rs915703103 |
119 | Y>H | No |
ClinGen Ensembl |
|
|
CA7956608 rs141905390 |
120 | R>K | No |
1000Genomes ESP ExAC TOPMed gnomAD ClinGen |
|
|
rs761615159 CA7956649 |
123 | E>K | No |
ExAC gnomAD ClinGen |
|
|
rs751580469 CA7956651 |
124 | L>R | No |
ExAC gnomAD ClinGen |
|
|
CA7956652 rs755197115 |
126 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7956653 rs767713407 |
128 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs998878236 CA279461628 |
130 | H>R | No |
TOPMed ClinGen |
|
|
rs868801012 CA279461636 |
131 | G>D | No |
ClinGen gnomAD |
|
|
rs1323785679 CA395097707 |
134 | Q>H | No |
gnomAD ClinGen |
|
|
rs753109806 CA7956654 |
136 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
rs777961720 CA395097752 |
137 | P>S | No |
ExAC gnomAD ClinGen |
|
|
rs777961720 CA7956656 |
137 | P>T | No |
ExAC gnomAD ClinGen |
|
|
CA279461656 rs1032063400 |
138 | S>G | No |
TOPMed ClinGen |
|
| TCGA novel | 138 | S>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7956657 rs749827957 |
141 | Y>F | No |
ExAC gnomAD ClinGen |
|
|
rs1476702796 CA395097918 |
144 | K>E | No |
TOPMed gnomAD ClinGen |
|
|
rs757650500 CA7956658 |
145 | A>T | No |
ExAC gnomAD ClinGen |
|
|
CA7956659 rs778574644 |
147 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA395097996 rs1456784810 |
148 | K>M | No |
ClinGen TOPMed |
|
|
rs1399860483 CA395098034 |
149 | H>Q | No |
ClinGen gnomAD |
|
|
CA279461665 rs1037454352 |
150 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs745370834 CA7956660 |
150 | R>W | No |
ExAC TOPMed gnomAD ClinGen |
|
|
CA7956662 rs775257915 |
154 | A>V | No |
ExAC TOPMed gnomAD ClinGen |
|
|
rs775054350 CA279461672 |
156 | N>D | No |
ClinGen Ensembl |
|
|
rs768524117 CA395098183 |
156 | N>K | No |
ClinGen ExAC gnomAD |
|
|
CA395098165 rs1224832754 |
156 | N>S | No |
ClinGen gnomAD |
|
|
rs776239466 CA7956665 |
157 | E>G | No |
ExAC ClinGen |
|
|
CA279461683 rs150646233 |
157 | E>K | No |
ESP TOPMed gnomAD ClinGen |
|
|
rs760957948 CA7956690 |
159 | G>R | No |
ClinGen ExAC gnomAD |
|
|
rs1330418091 CA395098381 |
160 | D>H | No |
ClinGen TOPMed gnomAD |
|
|
CA395098382 rs1330418091 |
160 | D>N | No |
ClinGen TOPMed gnomAD |
|
|
rs1338372524 CA395098437 |
162 | S>L | No |
ClinGen gnomAD |
|
|
rs1415872930 CA395098440 |
163 | Q>K | No |
TOPMed ClinGen |
|
|
rs764222376 CA7956691 |
164 | D>E | No |
ClinGen ExAC gnomAD |
|
|
CA7956693 rs561708810 |
166 | A>V | No |
1000Genomes ExAC TOPMed gnomAD ClinGen |
|
|
rs1250130159 CA395098539 |
167 | E>K | No |
gnomAD ClinGen |
|
|
rs990848535 COSM702291 CA279462207 |
168 | D>N | lung [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
rs185265815 CA7956696 |
169 | D>N | No |
1000Genomes ExAC TOPMed gnomAD ClinGen |
|
|
rs139739087 CA279462218 |
172 | Q>R | No |
ESP ClinGen |
|
|
rs779722712 CA7956697 |
174 | T>M | No |
ExAC TOPMed gnomAD ClinGen |
|
|
rs751138626 CA7956716 COSM288974 |
176 | R>W | large_intestine [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
rs754415880 CA7956717 |
177 | F>Y | No |
ExAC TOPMed gnomAD ClinGen |
|
|
CA7956718 rs780713502 |
178 | S>C | No |
ClinGen ExAC gnomAD |
|
|
CA395098929 rs1598255933 |
178 | S>P | No |
Ensembl ClinGen |
|
|
rs777551872 CA7956721 |
179 | R>Q | No |
ExAC gnomAD ClinGen |
|
|
rs755707764 CA395098965 |
179 | R>W | No |
ExAC TOPMed gnomAD ClinGen |
|
|
rs569078974 CA7956723 |
180 | P>L | No |
1000Genomes ExAC TOPMed gnomAD ClinGen |
|
|
rs1266704043 CA395099035 |
182 | S>L | No |
gnomAD ClinGen |
|
|
rs747148570 COSM1221520 CA7956725 |
186 | R>C | large_intestine [Cosmic] | No |
ExAC TOPMed gnomAD ClinGen cosmic curated |
|
CA279463344 rs375432266 |
186 | R>H | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs754456350 CA279463363 |
187 | Q>R | No |
ClinGen Ensembl |
|
|
rs1567317918 CA395099174 |
188 | R>H | No |
Ensembl ClinGen |
|
|
CA395099202 rs1157357479 |
189 | R>C | No |
TOPMed gnomAD ClinGen |
|
|
rs776721416 CA7956727 COSM183147 |
189 | R>H | large_intestine [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs776721416 CA395099207 |
189 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA395099222 rs1454643460 |
190 | V>L | No |
TOPMed gnomAD ClinGen |
|
|
CA395099217 rs1454643460 |
190 | V>M | No |
TOPMed gnomAD ClinGen |
|
|
rs200910698 CA7956728 |
191 | Q>R | No |
1000Genomes ESP ExAC TOPMed gnomAD ClinGen |
|
|
CA395099279 rs1347319205 |
192 | S>F | No |
ClinGen TOPMed |
|
|
rs1405091901 CA395099256 |
192 | S>T | No |
TOPMed ClinGen |
|
|
rs776848326 CA395099421 |
198 | K>N | No |
ExAC TOPMed gnomAD ClinGen |
|
|
rs773778199 CA7956730 |
198 | K>Q | No |
ExAC TOPMed gnomAD ClinGen |
|
|
rs371885512 CA7956732 |
199 | K>Q | No |
ESP ExAC TOPMed gnomAD ClinGen |
|
|
CA7956733 rs774752527 |
200 | H>N | No |
ClinGen ExAC gnomAD |
|
|
rs1317235714 CA395099475 |
201 | A>T | No |
gnomAD ClinGen |
|
|
rs765476062 CA279463469 |
202 | E>K | No |
ClinGen Ensembl |
|
|
CA395099545 rs1289458201 |
204 | P>A | No |
ClinGen gnomAD |
|
|
CA395099601 rs971837138 |
206 | V>A | No |
TOPMed ClinGen |
|
|
CA279463485 rs971837138 |
206 | V>D | No |
TOPMed ClinGen |
|
|
CA7956735 rs766950443 |
206 | V>I | No |
ExAC gnomAD ClinGen |
|
| TCGA novel | 207 | H>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1270484883 CA395099654 |
209 | H>P | No |
ClinGen gnomAD |
|
|
rs1270484883 CA395099650 |
209 | H>R | No |
ClinGen gnomAD |
|
|
rs1176210178 CA395099696 |
211 | Y>C | No |
ClinGen gnomAD |
|
|
rs1026506180 CA279463502 |
211 | Y>N | No |
gnomAD ClinGen |
|
|
CA7956738 rs763725832 |
213 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 214 | R>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs753686071 CA7956739 |
214 | R>K | No |
ClinGen ExAC gnomAD |
|
|
rs1201308693 CA395085789 |
215 | D>Y | No |
gnomAD ClinGen |
|
|
CA279414557 rs772279040 |
216 | S>G | No |
ClinGen gnomAD |
|
|
rs377091937 CA7956767 |
217 | R>C | No |
ESP ExAC TOPMed gnomAD ClinGen |
|
|
COSM3278686 CA7956768 rs771119082 |
217 | R>H | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA395085811 rs771119082 |
217 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA395085818 rs1474742496 |
219 | E>K | No |
ClinGen gnomAD |
|
|
rs763071220 CA279414561 |
220 | H>R | No |
TOPMed ClinGen |
|
|
CA7956769 rs201811894 |
222 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs139996135 CA7956770 |
222 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA279414578 rs767363672 |
225 | L>M | No |
Ensembl ClinGen |
|
|
rs1366413994 CA395086622 |
227 | C>F | No |
ClinGen TOPMed |
|
| TCGA novel | 227 | C>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1567319340 CA395086628 |
228 | P>S | No |
Ensembl ClinGen |
|
|
CA395086636 rs1335987533 |
229 | G>A | No |
ClinGen gnomAD |
|
|
CA395086634 rs1335987533 |
229 | G>D | No |
ClinGen gnomAD |
|
|
rs761135847 CA7956773 |
229 | G>S | No |
ExAC TOPMed gnomAD ClinGen |
|
|
rs768173463 CA7956774 |
230 | S>* | No |
ClinGen ExAC gnomAD |
|
|
rs750241086 CA7956778 |
232 | G>E | No |
ClinGen ExAC gnomAD |
|
|
CA7956777 rs776058208 CA7956776 |
232 | G>R | No |
ExAC gnomAD ClinGen |
|
|
rs750241086 CA395086651 |
232 | G>V | No |
ExAC gnomAD ClinGen |
|
|
CA7956775 rs776058208 |
232 | G>W | No |
ExAC gnomAD ClinGen |
|
|
CA395086657 rs1598258412 |
233 | V>G | No |
ClinGen Ensembl |
|
|
CA395086654 rs1282205389 |
233 | V>L | No |
gnomAD ClinGen |
|
|
CA7956780 rs766458827 |
236 | T>M | No |
ExAC TOPMed gnomAD ClinGen |
|
|
rs754906748 CA7956783 |
239 | V>I | No |
ExAC TOPMed gnomAD ClinGen |
|
|
CA7956782 COSM72248 rs754906748 |
239 | V>L | ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs1487801257 CA395086710 |
241 | S>L | No |
ClinGen TOPMed |
|
|
rs767550393 CA7956803 |
245 | Y>S | No |
ExAC gnomAD ClinGen |
|
| TCGA novel | 246 | L>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1057269313 CA279414949 COSM1221522 |
247 | M>I | large_intestine [Cosmic] | No |
TOPMed gnomAD ClinGen cosmic curated |
|
CA7956805 rs753916340 |
248 | M>L | No |
ExAC gnomAD ClinGen |
|
|
CA395086776 rs1159024515 |
250 | M>L | No |
ClinGen TOPMed |
|
|
rs1334844446 CA395086789 |
251 | P>L | No |
gnomAD ClinGen |
|
|
CA7956806 rs757331773 |
251 | P>S | No |
ClinGen ExAC gnomAD |
|
|
CA395086785 rs757331773 |
251 | P>T | No |
ClinGen ExAC gnomAD |
|
|
CA279414955 rs891555506 |
252 | P>S | No |
Ensembl ClinGen |
|
| TCGA novel | 253 | S>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7956808 rs778822737 |
255 | E>K | No |
ExAC gnomAD ClinGen |
|
|
CA7956809 rs750684693 |
256 | E>K | No |
ExAC TOPMed gnomAD ClinGen |
|
|
rs758553651 CA7956810 |
257 | E>G | No |
ExAC gnomAD ClinGen |
|
|
rs1357079132 CA395086837 |
258 | K>R | No |
gnomAD ClinGen |
|
|
CA395086858 rs758689506 |
259 | D>E | No |
ClinGen ExAC gnomAD |
|
|
CA395086856 rs1598259267 |
259 | D>G | No |
ClinGen Ensembl |
|
|
CA279415029 rs771589432 |
262 | V>L | No |
ExAC TOPMed gnomAD ClinGen |
|
|
CA7956828 rs771589432 |
262 | V>M | No |
ExAC TOPMed gnomAD ClinGen |
|
| TCGA novel | 263 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA279415040 rs202242656 |
267 | V>I | No |
ClinGen 1000Genomes gnomAD |
|
|
CA395086974 rs1376235154 |
268 | L>P | No |
ClinGen TOPMed gnomAD |
|
|
rs375530322 CA7956832 |
269 | S>L | No |
ESP ExAC TOPMed gnomAD ClinGen |
|
|
CA279415041 rs552361788 |
269 | S>P | No |
1000Genomes ClinGen |
|
|
CA7956834 rs777407366 |
272 | Q>H | No |
ExAC gnomAD ClinGen |
|
|
CA395087029 rs1426803084 |
272 | Q>P | No |
gnomAD ClinGen |
|
|
rs748792802 CA7956835 |
274 | R>C | No |
ExAC TOPMed gnomAD ClinGen |
|
|
CA395087052 rs1403521906 |
274 | R>H | No |
TOPMed gnomAD ClinGen |
|
|
CA395087054 rs1403521906 |
274 | R>L | No |
ClinGen TOPMed gnomAD |
|
|
CA395087061 rs1398378939 |
275 | T>A | No |
ClinGen gnomAD |
|
|
COSM434898 rs143440180 CA7956836 |
275 | T>M | breast [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
|
CA395087073 rs1219352475 |
276 | L>V | No |
TOPMed gnomAD ClinGen |
|
|
CA279415059 rs201302231 |
277 | P>T | No |
ClinGen 1000Genomes |
|
|
CA7956839 rs772010876 |
279 | A>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs371071744 CA7956842 |
280 | D>N | Variant assessed as Somatic; 0.0003326 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs773402964 CA7956843 |
281 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
rs766629925 CA7956845 |
286 | M>V | No |
ClinGen ExAC gnomAD |
|
|
CA279415084 rs1016274846 |
289 | V>L | No |
TOPMed gnomAD ClinGen |
|
|
rs1306098947 CA395087828 |
290 | K>R | No |
gnomAD ClinGen |
|
|
CA7956869 CA395087853 rs759821645 |
292 | M>I | No |
ClinGen ExAC gnomAD |
|
|
CA395087855 rs1242151886 |
293 | P>T | No |
ClinGen gnomAD |
|
|
CA7956871 rs753154066 |
296 | N>S | No |
ExAC gnomAD ClinGen |
|
|
rs966611333 CA279415920 |
298 | M>V | No |
Ensembl ClinGen |
|
|
COSM471490 CA7956872 rs760915656 |
299 | S>N | kidney [Cosmic] | No |
ExAC gnomAD ClinGen cosmic curated |
|
CA7956873 rs764477421 |
299 | S>R | No |
ExAC gnomAD ClinGen |
|
|
CA395087963 rs1362526686 |
301 | L>Q | No |
ClinGen TOPMed |
|
|
CA7956874 rs754416299 |
302 | G>D | No |
ExAC TOPMed gnomAD ClinGen |
|
|
rs749377196 CA279415937 |
303 | P>R | No |
Ensembl ClinGen |
|
|
CA7956875 rs200549196 |
303 | P>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs758131420 CA395088004 |
305 | I>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7956877 rs749953687 |
305 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA395088008 rs779553669 |
306 | D>H | No |
ExAC TOPMed gnomAD ClinGen |
|
|
CA7956879 rs779553669 |
306 | D>N | No |
ExAC TOPMed gnomAD ClinGen |
|
|
rs1567321895 CA395088025 |
307 | S>C | No |
Ensembl ClinGen |
|
|
rs9934667 CA279415948 |
308 | V>M | No |
ClinGen TOPMed gnomAD |
|
|
rs746863841 CA7956880 |
310 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA395088053 rs58061211 |
311 | L>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA395088064 rs1382000181 |
312 | R>Q | No |
ClinGen gnomAD |
|
|
CA7956882 rs780918282 |
312 | R>W | No |
ExAC TOPMed gnomAD ClinGen |
|
|
rs1356083923 CA395088179 |
322 | Q>H | No |
TOPMed ClinGen |
|
|
CA279415968 rs754996737 |
325 | W>* | No |
ClinGen Ensembl |
|
|
CA7956886 rs759510680 |
328 | K>R | No |
ExAC TOPMed gnomAD ClinGen |
|
|
rs1478958852 CA395088626 |
330 | D>G | No |
ClinGen gnomAD |
|
|
rs756092458 CA7956908 |
335 | K>Q | No |
ClinGen ExAC gnomAD |
|
|
rs150960440 CA7956910 |
336 | D>E | No |
ESP ExAC TOPMed gnomAD ClinGen |
|
|
rs777655970 CA7956909 |
336 | D>G | No |
ClinGen ExAC gnomAD |
|
|
COSM3936970 CA7956911 rs772064779 |
337 | S>L | Variant assessed as Somatic; 4.676e-05 impact. oesophagus [NCI-TCGA, Cosmic] | No |
ExAC gnomAD ClinGen cosmic curated NCI-TCGA |
|
rs372099828 CA7956913 |
338 | S>C | No |
ClinGen ESP ExAC gnomAD |
|
| TCGA novel | 338 | S>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 340 | P>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7956914 rs140752873 |
340 | P>S | No |
ESP ExAC TOPMed gnomAD ClinGen |
|
|
CA7956918 rs150257924 |
343 | G>C | No |
1000Genomes ESP ExAC TOPMed gnomAD ClinGen |
|
| TCGA novel | 343 | G>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7956917 rs150257924 |
343 | G>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs765822385 COSM968605 CA7956920 |
344 | V>M | endometrium [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs1215970911 CA395088825 |
345 | P>S | No |
ClinGen gnomAD |
|
|
rs1386685594 CA395088838 |
347 | E>Q | No |
ClinGen TOPMed |
|
|
rs1418586052 CA395088849 |
348 | V>A | No |
ClinGen TOPMed |
|
|
CA7956921 rs556363906 |
348 | V>M | No |
1000Genomes ExAC TOPMed gnomAD ClinGen |
|
|
rs767132871 CA7956923 |
350 | C>Y | No |
ExAC gnomAD ClinGen |
|
|
CA395088912 rs1478215202 |
352 | G>S | No |
ClinGen gnomAD |
|
|
rs370478447 CA7956926 |
353 | R>Q | No |
ESP ExAC TOPMed gnomAD ClinGen |
|
|
CA7956928 rs372913863 |
356 | V>I | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ESP ExAC TOPMed gnomAD ClinGen NCI-TCGA |
|
rs1598269535 CA395089796 |
357 | M>I | No |
ClinGen Ensembl |
|
|
CA395089780 rs1283737209 |
357 | M>L | No |
TOPMed gnomAD ClinGen |
|
|
rs1283737209 CA395089783 |
357 | M>V | No |
TOPMed gnomAD ClinGen |
|
|
CA395089841 rs1357143785 |
360 | F>L | No |
ClinGen TOPMed gnomAD |
|
|
CA279419477 rs113629353 |
360 | F>L | No |
Ensembl ClinGen |
|
|
rs749652288 CA279419498 |
361 | T>M | No |
ExAC TOPMed gnomAD ClinGen |
|
|
rs749652288 CA7956957 |
361 | T>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs147928355 CA7956959 |
364 | R>C | No |
ESP ExAC gnomAD ClinGen |
|
|
rs374794189 CA7956960 |
364 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 365 | W>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1598269609 CA395089935 |
366 | V>G | No |
Ensembl ClinGen |
|
|
CA395089948 rs1598269622 |
367 | V>G | No |
Ensembl ClinGen |
|
|
CA7956961 rs771581727 |
367 | V>I | No |
ExAC gnomAD ClinGen |
|
|
rs771581727 CA395089944 |
367 | V>L | No |
ExAC gnomAD ClinGen |
|
|
rs1280116782 CA395089955 |
368 | R>G | No |
TOPMed ClinGen |
|
|
CA395090009 rs1598269642 |
371 | V>G | No |
ClinGen Ensembl |
|
|
CA7956962 rs774911272 |
372 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs1339988559 CA395090039 |
373 | T>I | No |
ClinGen TOPMed |
|
|
COSM968606 rs760383677 CA7956963 |
374 | V>M | endometrium Variant assessed as Somatic; 4.619e-05 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
CA7956982 rs768236597 |
377 | L>F | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 378 | C>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7956984 rs371691617 |
378 | C>W | No |
ESP ExAC gnomAD ClinGen |
|
|
CA7956986 rs141897679 |
379 | A>P | No |
ESP ExAC TOPMed gnomAD ClinGen |
|
|
CA279419709 rs141897679 |
379 | A>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs141897679 CA7956985 |
379 | A>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA395090123 rs1598269940 |
379 | A>V | No |
Ensembl ClinGen |
|
|
CA395090130 rs1256493202 |
380 | E>K | No |
gnomAD ClinGen |
|
|
CA7956990 rs756248773 |
384 | D>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7956991 rs764031791 |
389 | M>V | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 390 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA395090311 rs1264868448 |
391 | V>A | No |
ClinGen gnomAD |
|
|
rs147107880 CA7956993 |
391 | V>M | No |
ESP ExAC TOPMed gnomAD ClinGen |
|
|
rs779398671 CA7956994 |
395 | N>S | No |
ExAC gnomAD ClinGen |
|
|
rs746214271 CA7956995 |
396 | K>R | No |
ExAC gnomAD ClinGen |
|
|
rs758949078 CA7956996 |
397 | G>R | No |
ExAC gnomAD ClinGen |
|
|
CA7956997 rs758949078 |
397 | G>S | No |
ClinGen ExAC gnomAD |
|
|
rs768237860 CA7956999 |
401 | I>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1567327000 CA395090449 |
403 | P>L | No |
Ensembl ClinGen |
|
|
rs867039838 CA279419818 |
404 | Y>H | No |
TOPMed ClinGen |
|
|
rs751557526 CA7957001 |
406 | G>A | No |
ExAC TOPMed gnomAD ClinGen |
|
|
rs751557526 CA279419828 |
406 | G>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ExAC TOPMed gnomAD ClinGen NCI-TCGA |
| TCGA novel | 407 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA279419835 rs149566181 |
410 | K>R | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA395090544 rs1567327037 |
413 | P>L | No |
Ensembl ClinGen |
|
|
rs1598270111 CA395090561 |
416 | V>F | No |
Ensembl ClinGen |
|
|
CA395090575 rs1387340923 |
418 | R>Q | No |
Ensembl ClinGen |
|
|
rs762820377 CA7957004 |
421 | M>I | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ExAC TOPMed gnomAD ClinGen NCI-TCGA |
|
rs375183154 CA395090603 |
422 | L>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs143215940 CA7957006 |
424 | T>A | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA7957007 rs759332570 |
424 | T>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ExAC TOPMed gnomAD ClinGen NCI-TCGA |
|
CA7957032 rs750669573 |
432 | K>N | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 432 | K>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs763108871 CA395090688 |
433 | V>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs763108871 CA7957033 |
433 | V>D | No |
ExAC TOPMed gnomAD ClinGen |
|
|
rs772687783 CA279420362 |
433 | V>I | No |
Ensembl ClinGen |
|
|
rs773451208 CA279420411 |
434 | Y>C | No |
Ensembl ClinGen |
|
|
CA279420414 rs915881605 |
435 | N>S | No |
TOPMed ClinGen |
|
|
rs1567327601 CA395090726 |
439 | E>K | No |
Ensembl ClinGen |
|
|
CA7957036 rs755567582 |
440 | T>A | No |
ExAC gnomAD ClinGen |
|
|
CA279420433 COSM1178741 rs1046200207 |
441 | M>I | prostate [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
rs1463849040 CA395090742 |
441 | M>T | No |
TOPMed gnomAD ClinGen |
|
|
rs781531432 CA7957037 |
442 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs902375642 CA279420445 |
443 | K>R | No |
ClinGen gnomAD |
|
|
CA7957039 rs760801732 |
445 | P>L | No |
ExAC TOPMed gnomAD ClinGen |
|
|
CA395090770 rs760801732 |
445 | P>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1314404520 CA395090774 |
446 | D>A | No |
gnomAD ClinGen |
|
|
rs1208552821 CA395090779 |
447 | A>T | No |
ClinGen TOPMed |
|
|
rs770702495 CA7957042 |
449 | S>* | No |
ExAC gnomAD ClinGen |
|
|
CA395090794 rs1598271082 |
449 | S>P | No |
Ensembl ClinGen |
|
|
CA395090827 rs1476254509 |
451 | P>L | No |
gnomAD ClinGen |
|
|
rs1567328180 CA395090829 |
452 | A>T | No |
Ensembl ClinGen |
|
|
CA7957062 rs202036790 |
453 | G>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
| TCGA novel | 454 | L>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA395090862 rs1433631114 |
456 | C>R | No |
ClinGen gnomAD |
|
|
rs1414580627 CA395090882 |
457 | G>E | No |
TOPMed ClinGen |
|
|
rs1175450714 CA395090876 |
457 | G>R | No |
ClinGen gnomAD |
|
|
rs1598271905 CA395090891 |
458 | D>A | No |
Ensembl ClinGen |
|
|
rs1484760171 CA395090918 |
460 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs757015119 CA7957063 |
460 | R>W | No |
ExAC TOPMed gnomAD ClinGen |
|
| TCGA novel | 463 | V>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs758153321 CA7957066 |
465 | K>E | No |
ClinGen ExAC gnomAD |
|
|
CA7957068 rs746957779 |
466 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs1026989135 CA279420877 |
467 | K>T | No |
TOPMed ClinGen |
|
|
CA395091001 rs1367354301 |
468 | A>T | No |
gnomAD ClinGen |
|
|
CA395091047 rs1351555402 |
471 | N>K | No |
ClinGen gnomAD |
|
|
CA279420903 rs915104697 |
471 | N>Y | No |
ClinGen Ensembl |
|
|
rs773340044 CA7957070 |
472 | H>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs749348251 CA7957071 COSM168509 |
473 | A>T | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
CA7957072 rs771185200 |
473 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7957075 rs749940428 |
475 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs749940428 CA395091088 |
475 | L>R | No |
ExAC gnomAD ClinGen |
|
|
CA7957076 rs767775925 |
476 | E>G | No |
ExAC TOPMed gnomAD ClinGen |
|
|
CA395091099 rs775917917 |
477 | R>G | No |
ClinGen ExAC gnomAD |
|
|
CA395091101 rs1158784306 |
477 | R>P | No |
ClinGen gnomAD |
|
|
rs1158784306 CA395091100 |
477 | R>Q | No |
gnomAD ClinGen |
|
|
CA7957077 rs775917917 |
477 | R>W | No |
ClinGen ExAC gnomAD |
|
|
rs889756713 CA279420953 |
478 | E>D | No |
Ensembl ClinGen |
|
|
CA279420957 rs866473226 |
479 | L>R | No |
Ensembl ClinGen |
|
|
rs764672973 CA7957079 |
481 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1403176455 CA395091138 |
481 | R>W | No |
gnomAD ClinGen |
|
|
rs377295700 CA7957081 |
482 | R>Q | No |
1000Genomes ExAC TOPMed gnomAD ClinGen |
|
|
rs753434811 CA7957080 |
482 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs369986679 CA279421002 |
483 | K>E | No |
ClinGen TOPMed gnomAD |
|
|
rs369986679 CA279420999 |
483 | K>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs1474265127 CA395091172 |
484 | E>V | No |
ClinGen TOPMed |
|
|
CA7957083 rs750060291 |
485 | Q>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs372825350 CA7957085 |
487 | R>Q | No |
ClinGen 1000Genomes ESP ExAC gnomAD |
|
|
rs755589505 CA7957084 |
487 | R>W | No |
ExAC gnomAD ClinGen |
|
|
rs754958246 CA7957087 |
488 | V>L | No |
ClinGen ExAC gnomAD |
|
|
rs754958246 CA395091207 |
488 | V>M | No |
ClinGen ExAC gnomAD |
|
|
CA7957089 COSM3690849 rs748039763 |
490 | A>V | large_intestine [Cosmic] | No |
ExAC TOPMed gnomAD ClinGen cosmic curated |
|
CA395091258 rs1414127620 |
492 | P>L | No |
ClinGen gnomAD |
|
|
CA395091253 rs772324916 |
492 | P>S | No |
ExAC TOPMed gnomAD ClinGen |
|
|
CA7957093 rs772324916 |
492 | P>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA279421060 rs981757134 |
493 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
rs764509661 CA7957096 |
493 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs911079460 CA279421072 |
494 | G>A | No |
TOPMed ClinGen |
|
|
CA7957100 rs764660130 |
494 | G>R | No |
ExAC TOPMed gnomAD ClinGen |
|
|
rs764660130 CA7957099 |
494 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM417109 CA7957104 rs754799887 |
496 | R>Q | urinary_tract Variant assessed as Somatic; 4.993e-05 impact. [Cosmic, NCI-TCGA] | No |
ExAC TOPMed gnomAD ClinGen cosmic curated NCI-TCGA |
|
rs751395979 CA7957103 |
496 | R>W | No |
ExAC gnomAD ClinGen |
|
|
rs780918240 CA7957105 |
497 | I>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs371078507 CA279421096 |
498 | K>E | No |
ESP TOPMed gnomAD ClinGen |
|
|
rs1229645366 CA395091367 |
502 | V>A | No |
ClinGen TOPMed |
|
|
rs756072532 CA7957110 |
502 | V>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs756072532 CA7957109 |
502 | V>M | No |
ExAC gnomAD ClinGen |
|
|
CA7957113 rs745937923 |
503 | S>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1440169851 CA395091387 |
504 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs772220112 CA7957114 |
506 | G>S | No |
ClinGen ExAC gnomAD |
|
|
rs1014487503 CA279421169 |
507 | E>K | No |
TOPMed gnomAD ClinGen |
|
|
rs747177864 CA7957118 |
507 | E>V | No |
ClinGen ExAC gnomAD |
|
|
CA395091440 rs1465458774 |
508 | E>A | No |
ClinGen gnomAD |
|
|
rs762296208 CA7957121 |
509 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1342489786 CA395091455 |
509 | D>G | No |
ClinGen gnomAD |
|
|
rs141715155 CA7957120 |
509 | D>N | No |
1000Genomes ESP ExAC TOPMed gnomAD ClinGen |
|
|
CA395091467 rs1399318708 |
510 | E>* | No |
ClinGen TOPMed gnomAD |
|
|
rs1399318708 CA395091463 |
510 | E>K | No |
TOPMed gnomAD ClinGen |
|
|
CA395091465 rs1399318708 |
510 | E>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA395091485 rs751236431 |
511 | E>D | No |
ExAC gnomAD ClinGen |
|
|
CA7957125 rs762493496 |
511 | E>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs193242301 CA279421197 |
511 | E>Q | No |
1000Genomes ClinGen |
|
|
rs762493496 CA7957124 |
511 | E>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1416794664 CA395091489 |
512 | Q>* | No |
gnomAD ClinGen |
|
|
rs767365470 CA7957128 |
513 | E>D | No |
ExAC TOPMed gnomAD ClinGen |
|
|
CA7957127 rs759132942 |
513 | E>V | No |
ExAC gnomAD ClinGen |
|
|
rs1227940874 CA395091501 |
514 | A>T | No |
gnomAD ClinGen |
|
|
rs1252985120 CA395091506 |
514 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA7957129 rs752474199 |
515 | E>K | No |
ExAC gnomAD ClinGen |
|
|
CA7957130 rs536043041 |
516 | E>A | No |
1000Genomes ExAC gnomAD ClinGen |
|
|
rs753674369 CA7957132 CA395091527 |
517 | E>D | No |
ExAC gnomAD ClinGen |
|
|
CA395091523 rs1486378205 |
517 | E>Q | No |
gnomAD ClinGen |
|
|
CA395091532 rs1394493342 |
518 | P>R | No |
TOPMed ClinGen |
|
|
rs897176305 CA279421272 |
519 | M>I | No |
TOPMed gnomAD ClinGen |
|
|
CA7957133 rs199833918 |
519 | M>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA395091534 rs1428265755 |
519 | M>V | No |
gnomAD ClinGen |
|
|
rs780221573 CA7957134 |
520 | D>G | No |
ExAC TOPMed gnomAD ClinGen |
|
|
CA395091561 rs1376096839 |
523 | P>A | No |
gnomAD ClinGen |
|
|
CA7957135 rs747241540 |
524 | S>R | No |
ExAC gnomAD ClinGen |
|
|
CA395091569 rs1454147949 |
524 | S>T | No |
ClinGen TOPMed |
|
|
CA7957136 rs768999204 |
525 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7957137 rs781730179 |
526 | L>F | No |
ExAC gnomAD ClinGen |
|
|
CA395091594 rs1297544493 |
528 | S>N | No |
ClinGen gnomAD |
|
|
CA7957139 rs770243846 |
531 | A>D | No |
ClinGen ExAC gnomAD |
|
|
CA395091615 rs770243846 |
531 | A>G | No |
ExAC gnomAD ClinGen |
|
|
rs373929935 CA279421330 |
533 | G>R | No |
ClinGen ESP TOPMed |
|
|
CA395091640 rs1486028811 |
535 | P>L | No |
ClinGen gnomAD |
|
|
CA395091637 rs1284849121 |
535 | P>S | No |
ClinGen gnomAD |
|
| TCGA novel | 536 | L>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7957144 rs139179088 CA7957143 |
537 | G>R | No |
ClinGen ESP ExAC gnomAD |
|
|
CA7957146 rs368340336 |
538 | R>Q | No |
ESP ExAC gnomAD ClinGen |
|
|
rs533624898 CA7957145 |
538 | R>W | No |
1000Genomes ExAC TOPMed gnomAD ClinGen |
|
|
CA395091664 rs1396253859 |
540 | A>V | No |
gnomAD ClinGen |
|
|
rs763744993 CA7957148 |
541 | G>C | No |
ClinGen ExAC gnomAD |
|
|
rs544951596 COSM1221519 CA7957149 |
541 | G>D | large_intestine [Cosmic] | No |
1000Genomes ExAC gnomAD ClinGen cosmic curated |
|
rs1029700316 CA279421391 |
542 | T>R | No |
ClinGen TOPMed gnomAD |
|
|
rs61744759 CA279421393 |
543 | D>H | No |
1000Genomes ESP ExAC TOPMed gnomAD ClinGen |
|
|
rs61744759 CA7957150 |
543 | D>Y | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA7957151 rs766635425 |
544 | S>G | No |
ClinGen ExAC gnomAD |
|
|
CA395091685 rs1290874133 |
544 | S>N | No |
ClinGen gnomAD |
|
|
rs1388254524 CA395091690 |
545 | F>L | No |
gnomAD ClinGen |
|
|
rs1373174369 CA395091705 |
547 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
CA395091714 rs1598272863 |
548 | H>P | No |
Ensembl ClinGen |
|
|
CA7957154 rs781538164 |
549 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA395091728 rs1433834500 |
550 | P>L | No |
TOPMed gnomAD ClinGen |
|
|
CA7957157 rs777943370 |
550 | P>S | No |
ExAC TOPMed gnomAD ClinGen |
|
|
CA395091731 rs1263344734 |
551 | Q>* | No |
ClinGen gnomAD |
|
|
rs749807864 CA7957158 |
551 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
CA7957159 rs771412352 |
552 | G>C | No |
ExAC gnomAD ClinGen |
|
|
CA7957163 rs775226382 |
554 | A>D | No |
ClinGen ExAC gnomAD |
|
|
rs375146644 CA7957162 |
554 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ESP ExAC TOPMed gnomAD ClinGen NCI-TCGA |
|
rs1161509350 CA395091756 |
555 | S>N | No |
ClinGen TOPMed gnomAD |
|
|
CA395091764 rs1485734052 |
556 | T>N | No |
TOPMed ClinGen |
|
|
CA395091767 rs1228462761 |
557 | P>T | No |
ClinGen gnomAD |
|
|
CA395091773 rs1460715936 |
558 | V>M | No |
ClinGen gnomAD |
|
|
rs868635639 CA279421482 |
559 | A>D | No |
Ensembl ClinGen |
|
|
rs1396417428 CA395091781 |
559 | A>S | No |
gnomAD ClinGen |
|
|
rs868635639 CA279421488 |
559 | A>V | No |
Ensembl ClinGen |
|
|
rs776282819 CA7957166 |
560 | R>P | No |
ClinGen ExAC gnomAD |
|
|
CA7957165 rs370224362 |
560 | R>W | No |
ESP ExAC TOPMed gnomAD ClinGen |
|
|
rs1289043237 CA395091786 |
561 | E>K | No |
TOPMed gnomAD ClinGen |
|
|
CA7957167 rs761903860 |
563 | K>N | No |
ClinGen ExAC gnomAD |
|
|
CA7957168 rs545491852 |
564 | A>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA395091821 CA395091820 rs1233055917 |
566 | V>L | No |
ClinGen TOPMed gnomAD |
|
|
CA395091819 rs1233055917 |
566 | V>M | No |
TOPMed gnomAD ClinGen |
|
|
rs1274131743 CA395091829 |
567 | E>G | No |
ClinGen gnomAD |
|
|
CA395091836 rs755140834 |
568 | A>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA395091834 rs1348842437 |
568 | A>P | No |
TOPMed ClinGen |
|
|
CA7957170 rs755140834 |
568 | A>V | No |
ExAC TOPMed gnomAD ClinGen |
|
|
CA279421549 rs1056044152 |
570 | F>L | No |
ClinGen TOPMed gnomAD |
|
|
CA7957171 rs767447138 |
570 | F>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1179080472 CA395091881 |
575 | V>M | No |
ClinGen gnomAD |
|
|
rs752978634 CA7957172 |
577 | T>A | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 580 | E>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs749592536 CA7957175 |
580 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1463897933 CA395091933 |
583 | R>C | No |
gnomAD ClinGen |
|
|
CA7957176 rs757800689 |
583 | R>H | No |
ExAC TOPMed gnomAD ClinGen |
|
|
rs1355093817 CA395091939 |
584 | L>F | No |
ClinGen gnomAD |
|
|
CA7957177 rs779427318 |
586 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7957181 rs377754724 |
593 | P>S | No |
ESP ExAC TOPMed gnomAD ClinGen |
|
|
rs377754724 CA395091997 |
593 | P>T | No |
ESP ExAC TOPMed gnomAD ClinGen |
|
| rs777556882 | 595 | G>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7957185 rs761673211 |
595 | G>S | No |
ClinGen ExAC gnomAD |
|
|
rs1217653119 CA395092016 |
596 | H>Y | No |
TOPMed ClinGen |
|
|
CA395092033 rs1207247345 |
598 | L>H | No |
gnomAD ClinGen |
|
|
CA395092035 rs1485397859 |
599 | F>L | No |
gnomAD ClinGen |
|
|
CA395092038 rs1182571977 |
599 | F>S | No |
gnomAD ClinGen |
|
|
CA395092050 rs773304266 |
601 | G>C | No |
ClinGen ExAC gnomAD |
|
|
CA7957188 rs773304266 |
601 | G>R | No |
ClinGen ExAC gnomAD |
|
|
rs773304266 CA279421625 |
601 | G>S | No |
ExAC gnomAD ClinGen |
|
|
rs527434936 CA279421635 |
602 | I>F | No |
ClinGen ExAC gnomAD |
|
|
rs1422536180 CA395092056 |
602 | I>T | No |
ClinGen TOPMed gnomAD |
|
|
CA7957189 rs527434936 |
602 | I>V | No |
ExAC gnomAD ClinGen |
|
|
CA395092070 rs1476706405 |
603 | S>L | No |
TOPMed gnomAD ClinGen |
|
|
rs1420140642 CA395092083 |
604 | D>E | No |
ClinGen gnomAD |
|
|
CA395092086 rs1430168280 |
605 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
gnomAD ClinGen NCI-TCGA |
|
CA7957190 rs767640780 |
605 | R>H | No |
ExAC TOPMed gnomAD ClinGen |
|
|
CA395092091 rs767640780 |
605 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1000769661 CA279421646 |
606 | M>V | No |
ClinGen TOPMed |
|
|
rs1429054307 CA395092117 |
608 | Q>E | No |
TOPMed ClinGen |
|
|
rs761005584 COSM1189213 CA7957192 |
610 | T>M | lung [Cosmic] | No |
ExAC ClinGen cosmic curated |
|
CA395092155 rs1358294337 |
611 | V>A | No |
gnomAD ClinGen |
|
|
rs1429052985 CA395092158 |
612 | L>V | No |
gnomAD ClinGen |
|
|
rs368901417 CA7957195 |
614 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs948337022 CA279421682 |
615 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
rs948337022 CA395092184 |
615 | G>S | No |
ClinGen TOPMed gnomAD |
|
|
rs1162196904 CA395092269 |
622 | P>T | No |
ClinGen TOPMed |
|
|
rs762078477 CA395093172 |
623 | F>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7957235 rs762078477 |
623 | F>L | No |
ExAC TOPMed gnomAD ClinGen |
|
|
CA7957238 rs773608191 |
624 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA279423979 rs1052423646 |
626 | Q>E | No |
ClinGen TOPMed gnomAD |
|
|
rs1052423646 CA395093214 |
626 | Q>K | No |
TOPMed gnomAD ClinGen |
|
|
CA7957240 rs766718523 |
626 | Q>P | No |
ExAC gnomAD ClinGen |
|
|
rs148649380 CA7957241 |
628 | A>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA395093257 rs1228006433 |
629 | A>V | No |
ClinGen gnomAD |
|
|
rs755450212 COSM3948377 CA7957242 |
631 | P>A | ovary [Cosmic] | No |
ExAC gnomAD ClinGen cosmic curated |
|
CA7957243 rs767206740 |
631 | P>L | No |
ExAC TOPMed gnomAD ClinGen |
|
|
CA279423998 rs767206740 |
631 | P>R | No |
ExAC TOPMed gnomAD ClinGen |
|
|
rs755450212 CA395093273 |
631 | P>S | No |
ClinGen ExAC gnomAD |
|
|
CA7957245 rs755869115 |
633 | E>K | No |
ExAC TOPMed gnomAD ClinGen |
|
| TCGA novel | 635 | K>missing | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA279424018 rs376028275 |
638 | A>V | No |
ESP TOPMed gnomAD ClinGen |
|
|
rs748918167 CA7957247 |
642 | S>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1323440283 CA395093423 |
643 | G>R | No |
TOPMed ClinGen |
|
| TCGA novel | 647 | D>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA395093490 rs1253136278 |
648 | Q>K | No |
TOPMed gnomAD ClinGen |
|
|
rs769877164 CA7957275 |
649 | H>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs749543511 CA7957277 |
650 | R>* | No |
ExAC gnomAD ClinGen |
|
|
CA279430366 rs1018078412 |
650 | R>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA395094131 rs1274307170 |
655 | E>Q | No |
gnomAD ClinGen |
|
| TCGA novel | 659 | K>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 660 | N>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs868058149 CA279430393 |
662 | R>W | No |
ClinGen Ensembl |
|
|
rs947796262 CA279430400 |
664 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
CA7957282 rs374321456 |
664 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7957283 rs761192914 |
665 | R>* | No |
ExAC gnomAD ClinGen |
|
|
rs1045218409 CA279430418 |
665 | R>Q | No |
Ensembl ClinGen |
|
|
rs1324733922 CA395094429 |
667 | M>K | No |
TOPMed ClinGen |
|
|
rs1229653303 CA395094426 |
667 | M>L | No |
TOPMed ClinGen |
|
|
rs1324733922 CA395094431 |
667 | M>T | No |
ClinGen TOPMed |
|
|
rs183932619 CA395094500 |
671 | R>L | No |
1000Genomes ESP ExAC TOPMed gnomAD ClinGen |
|
|
CA7957285 rs183932619 |
671 | R>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA7957284 rs763763238 |
671 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA395094502 rs761419294 |
672 | L>M | No |
ClinGen ExAC gnomAD |
|
|
rs764909521 CA7957287 |
673 | T>I | No |
ExAC gnomAD ClinGen |
|
|
CA7957289 rs758213533 |
675 | E>D | No |
ExAC gnomAD ClinGen |
|
|
rs1460029979 CA395094550 |
675 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
CA395094613 rs1476216707 |
679 | D>E | No |
TOPMed ClinGen |
|
|
CA7957290 rs779767153 |
681 | S>N | No |
ExAC gnomAD ClinGen |
|
|
rs144564107 CA7957291 |
682 | K>Q | No |
1000Genomes ExAC gnomAD ClinGen |
|
|
rs1353985822 CA395094647 |
682 | K>R | No |
ClinGen gnomAD |
|
|
rs754909996 CA7957292 |
683 | Q>* | No |
ExAC ClinGen |
|
|
CA7957293 rs777777289 |
683 | Q>P | No |
ClinGen ExAC gnomAD |
|
|
rs1370825676 CA395094709 |
687 | K>E | No |
ClinGen TOPMed |
|
| TCGA novel | 688 | V>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA395094742 rs1567335393 |
689 | L>Q | No |
ClinGen Ensembl |
|
|
rs781155231 CA7957316 |
692 | C>Y | No |
ClinGen ExAC gnomAD |
|
|
CA7957319 rs778788100 |
695 | S>R | No |
ExAC gnomAD ClinGen |
|
|
CA7957318 rs757368468 |
695 | S>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7957320 rs34634941 |
696 | Y>C | No |
ExAC TOPMed gnomAD ClinGen |
|
|
CA395094975 rs34634941 |
696 | Y>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA279431926 rs34634941 |
696 | Y>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7957321 rs758679787 |
698 | G>D | No |
ClinGen ExAC gnomAD |
|
|
CA395095007 rs1366473468 |
699 | M>L | No |
ClinGen gnomAD |
|
|
CA279431941 rs967787753 |
700 | W>* | No |
TOPMed gnomAD ClinGen |
|
|
CA7957322 rs780614164 |
700 | W>C | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 704 | G>W | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1388947859 CA395095107 |
706 | V>A | No |
ClinGen gnomAD |
|
|
CA7957324 rs768860071 |
707 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
CA395095230 rs753637249 |
707 | Q>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA395095233 rs1314930622 |
708 | S>P | No |
ClinGen gnomAD |
|
|
CA7957326 rs748547202 |
709 | S>R | No |
ExAC gnomAD ClinGen |
No associated diseases with Q9NVU0
1 regional properties for Q9NVU0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | DNA-directed RNA polymerase III subunit RPC5, C-terminal | 443 - 708 | IPR045576 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| RNA polymerase III complex | RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| defense response to virus | Reactions triggered in response to the presence of a virus that act to protect the cell or organism. |
| DNA-templated transcription | The synthesis of an RNA transcript from a DNA template. |
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MANEEDDPVV | QEIDVYLAKS | LAEKLYLFQY | PVRPASMTYD | DIPHLSAKIK | PKQQKVELEM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AIDTLNPNYC | RSKGEQIALN | VDGACADETS | TYSSKLMDKQ | TFCSSQTTSN | TSRYAAALYR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QGELHLTPLH | GILQLRPSFS | YLDKADAKHR | EREAANEAGD | SSQDEAEDDV | KQITVRFSRP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ESEQARQRRV | QSYEFLQKKH | AEEPWVHLHY | YGLRDSRSEH | ERQYLLCPGS | SGVENTELVK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SPSEYLMMLM | PPSQEEEKDK | PVAPSNVLSM | AQLRTLPLAD | QIKILMKNVK | VMPFANLMSL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LGPSIDSVAV | LRGIQKVAML | VQGNWVVKSD | ILYPKDSSSP | HSGVPAEVLC | RGRDFVMWKF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TQSRWVVRKE | VATVTKLCAE | DVKDFLEHMA | VVRINKGWEF | ILPYDGEFIK | KHPDVVQRQH |
| 430 | 440 | 450 | 460 | 470 | 480 |
| MLWTGIQAKL | EKVYNLVKET | MPKKPDAQSG | PAGLVCGDQR | IQVAKTKAQQ | NHALLERELQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RRKEQLRVPA | VPPGVRIKEE | PVSEEGEEDE | EQEAEEEPMD | TSPSGLHSKL | ANGLPLGRAA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GTDSFNGHPP | QGCASTPVAR | ELKAFVEATF | QRQFVLTLSE | LKRLFNLHLA | SLPPGHTLFS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GISDRMLQDT | VLAAGCKQIL | VPFPPQTAAS | PDEQKVFALW | ESGDMSDQHR | QVLLEIFSKN |
| 670 | 680 | 690 | 700 | ||
| YRVRRNMIQS | RLTQECGEDL | SKQEVDKVLK | DCCVSYGGMW | YLKGTVQS |