AiPD: Autoinhibited Protein Database

Q9NTI7

Gene name	INKA2
Protein name	PAK4-inhibitor INKA2
Names	Induced in neural crest by AP2-alpha protein-related homolog, HInca-r, Inka box actin regulator 2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:55924
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

149-297 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

149-297 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9NTI7

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9NTI7-F1	Predicted				AlphaFoldDB

256 variants for Q9NTI7

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA1006625 rs779617617	2	T>M		No	ClinGen ExAC TOPMed gnomAD
CA341633546 rs1169423012	3	M>I		No	ClinGen TOPMed
rs749901390 CA1006623	6	R>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	6	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1006620 rs764184754	9	D>A		No	ClinGen ExAC TOPMed gnomAD
rs764184754 CA1006619	9	D>G		No	ClinGen ExAC TOPMed gnomAD
rs756832621 CA1006621	9	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1436215725 CA341633498	10	C>Y		No	ClinGen TOPMed
rs1273529192 CA341633489	11	Y>C		No	ClinGen TOPMed
rs1188621345 CA341633474	13	R>H		No	ClinGen TOPMed gnomAD
CA341633476 rs1188621345	13	R>L		No	ClinGen TOPMed gnomAD
CA341633469 rs1446985862	14	R>P		No	ClinGen gnomAD
rs752544051 CA1006617	16	K>E		No	ClinGen ExAC gnomAD
CA341633458 COSM893875 rs1571596591	16	K>R	endometrium [Cosmic]	No	ClinGen cosmic curated Ensembl
CA1006615 rs141241151	18	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA341633445 rs1488978771	18	E>Q		No	ClinGen gnomAD
CA341633436 rs1324763263	19	L>P		No	ClinGen TOPMed gnomAD
CA341633438 rs1244792336	19	L>V		No	ClinGen gnomAD
rs746461949 CA1006585	20	M>I		No	ClinGen ExAC TOPMed gnomAD
rs370379166 CA1006586	20	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA1006584 rs777443274	22	M>T		No	ClinGen ExAC gnomAD
rs1208150490 CA341641329	23	K>Q		No	ClinGen TOPMed
CA341641308 rs1275439894	24	E>K		No	ClinGen gnomAD
rs779057031 CA1006581	30	Q>R		No	ClinGen ExAC gnomAD
CA1006580 rs373131514	33	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs766474863 CA1006578	35	C>*		No	ClinGen ExAC gnomAD
CA1006577 rs756385584	36	M>L		No	ClinGen ExAC TOPMed gnomAD
CA341641131 rs756385584	36	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1426703311 CA341641095	37	M>I		No	ClinGen gnomAD
CA28891907 rs969551656	37	M>K		No	ClinGen Ensembl
rs1416598417 CA341641111	37	M>L		No	ClinGen gnomAD
CA341641086 rs1172607134	38	G>S		No	ClinGen gnomAD
TCGA novel	39	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1006576 rs750694210	40	L>P		No	ClinGen ExAC gnomAD
rs1156301482 CA341641053	41	Q>*		No	ClinGen TOPMed
CA341641020 rs1458040052	42	E>G		No	ClinGen gnomAD
COSM893873 CA341641039 rs1180353240	42	E>K	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1201699067 CA341640976	45	L>F		No	ClinGen TOPMed gnomAD
CA341640958 rs1313838884	46	L>H		No	ClinGen gnomAD
CA1006574 rs761949517	48	V>L		No	ClinGen ExAC gnomAD
rs1311735015 CA341640911	49	Q>H		No	ClinGen gnomAD
CA341640913 rs1348856670	49	Q>R		No	ClinGen gnomAD
CA1006573 rs752046956	50	T>I		No	ClinGen ExAC TOPMed gnomAD
CA1006572 rs764672851	54	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1022682939 CA28891868	60	G>R		No	ClinGen Ensembl
rs202217076 CA28891863	61	G>V		No	ClinGen 1000Genomes TOPMed gnomAD
CA341640730 rs1334290946	63	V>L		No	ClinGen gnomAD
CA341640710 rs1378165479	64	P>S		No	ClinGen gnomAD
rs1336846599 CA341640699	65	G>S		No	ClinGen TOPMed
CA341640685 rs1439859118	66	S>I		No	ClinGen gnomAD
CA1006570 rs775954366	66	S>R		No	ClinGen ExAC gnomAD
CA341640665 rs1384408956	67	P>L		No	ClinGen gnomAD
CA1006569 rs143162290	68	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA1006568 rs760349464	69	G>C		No	ClinGen ExAC TOPMed gnomAD
rs1237950993 CA341640603	71	R>S		No	ClinGen gnomAD
CA1006566 rs771701834	75	E>K		No	ClinGen ExAC TOPMed gnomAD
CA341640534 rs1197314121	76	H>Y		No	ClinGen TOPMed
rs531482804 CA1006564	78	C>F		No	ClinGen ExAC TOPMed gnomAD
rs531482804 CA28891771	78	C>Y		No	ClinGen ExAC TOPMed gnomAD
rs866041475 CA28891755	79	W>*		No	ClinGen Ensembl
rs1230358614 CA341640485	80	E>K		No	ClinGen gnomAD
rs1230358614 CA341640487	80	E>Q		No	ClinGen gnomAD
CA28891748 rs1006595142	81	G>C		No	ClinGen TOPMed
rs768675152 CA1006563	86	A>T		No	ClinGen ExAC TOPMed gnomAD
rs748990798 CA1006562	89	T>I		No	ClinGen ExAC TOPMed gnomAD
rs1174780355 CA341640257	92	S>F		No	ClinGen TOPMed
CA341640249 rs1419949718	93	P>A		No	ClinGen gnomAD
CA1006561 rs779876709	93	P>L		No	ClinGen ExAC gnomAD
rs1375540597 CA341640219	95	S>R		No	ClinGen TOPMed
rs1414518180 CA341640163	98	S>P		No	ClinGen TOPMed gnomAD
TCGA novel	99	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs371292774 CA1006559	101	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA341640113 rs1265465982	101	S>R		No	ClinGen gnomAD
CA341640099 rs1217405304	102	S>N		No	ClinGen gnomAD
rs1571589837 CA341640087	103	T>P		No	ClinGen Ensembl
rs1431089104 CA341640070	104	K>Q		No	ClinGen TOPMed gnomAD
rs1490259383 CA341640046	105	F>L		No	ClinGen gnomAD
CA341640011 rs1392952911	107	S>Y		No	ClinGen gnomAD
CA1006558 rs781453283	110	S>I		No	ClinGen ExAC TOPMed gnomAD
CA341639963 rs781453283	110	S>N		No	ClinGen ExAC TOPMed gnomAD
rs1347973212 CA341639957	111	V>I		No	ClinGen TOPMed
CA28891670 rs80140747	115	D>G		No	ClinGen Ensembl
rs145633487 CA1006557	118	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1322715589 CA341639857	118	P>S		No	ClinGen gnomAD
CA1006555 rs764467945	120	P>S		No	ClinGen ExAC TOPMed gnomAD
CA341639820 TCGA novel rs1400046356	121	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen gnomAD NCI-TCGA
CA1006554 rs376399692	121	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA341639815 rs1344545291	121	R>T		No	ClinGen gnomAD
CA1006553 rs753190443	123	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs765602502 CA1006552	125	H>N		No	ClinGen ExAC gnomAD
CA341639711 rs1480143794	128	C>Y		No	ClinGen gnomAD
CA1006549 rs771859200	132	G>E		No	ClinGen ExAC TOPMed gnomAD
rs772982701 CA1006550	132	G>R		No	ClinGen ExAC gnomAD
CA1006546 rs145067004	135	R>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1006544 rs199666460	135	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs769619836 CA1006543	138	P>L		No	ClinGen ExAC TOPMed gnomAD
CA341639553 rs1557908584	139	D>G		No	ClinGen Ensembl
rs1167149068 CA341639520	141	W>*		No	ClinGen TOPMed
CA28891501 rs925490875	141	W>L		No	ClinGen Ensembl
CA341639517 rs1201406661	142	T>A		No	ClinGen gnomAD
CA341639518 rs1201406661	142	T>P		No	ClinGen gnomAD
rs868792785 CA28891497	143	S>F		No	ClinGen Ensembl
rs141026018 CA1006540	144	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1571589688 CA341639498	144	T>P		No	ClinGen Ensembl
CA341639471 rs1296505439	146	M>I		No	ClinGen TOPMed
CA341639475 rs777883892	146	M>K		No	ClinGen ExAC TOPMed gnomAD
CA1006537 rs777883892	146	M>T		No	ClinGen ExAC TOPMed gnomAD
CA1006536 rs529338359	147	S>Y		No	ClinGen ExAC gnomAD
rs142952172 CA1006534	148	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA341639454 rs142952172	148	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1006533 rs142952172	148	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs778981316 CA28891452	148	R>W		No	ClinGen TOPMed gnomAD
TCGA novel	149	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1316959367 CA341639446	149	G>D		No	ClinGen TOPMed
rs374661986 CA1006530	150	R>G		No	ClinGen ESP ExAC gnomAD
rs773915828 CA1006529	150	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs374661986 CA1006531	150	R>W		No	ClinGen ESP ExAC gnomAD
rs267597925 CA28891412 COSM893870	152	R>*	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs373194330 CA1006527	152	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs373194330 CA28891403	152	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA341639417 rs1205225505	153	Q>E		No	ClinGen TOPMed
CA341639407 rs775441583	153	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA1006524 rs756332197	158	G>E		No	ClinGen ExAC gnomAD
rs770762076 CA1006522	159	D>N		No	ClinGen ExAC TOPMed gnomAD
CA28891356 rs567520346	160	N>D		No	ClinGen Ensembl
rs376225653 CA1006520 COSM423458	161	V>I	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1304699123 CA341639272	164	D>E		No	ClinGen gnomAD
rs758489520 CA1006519	164	D>N		No	ClinGen ExAC gnomAD
CA341639246 rs1557908482	167	G>R		No	ClinGen Ensembl
rs1557908478 CA341639221	168	N>S		No	ClinGen Ensembl
COSM1198425 rs779438654 CA1006517	169	W>C	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs781528757 CA28891322	173	P>Q		No	ClinGen TOPMed
CA1006516 rs755567208	173	P>T		No	ClinGen ExAC gnomAD
rs1321345188 CA341639140	174	E>K		No	ClinGen TOPMed
TCGA novel	176	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341639092 rs1388151537	177	K>R		No	ClinGen TOPMed
rs1441239950 CA341639058	179	G>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs766824312 CA1006513	180	E>Q		No	ClinGen ExAC gnomAD
CA341639027 rs1483299518	181	K>N		No	ClinGen gnomAD
rs756614102 CA1006512	181	K>T		No	ClinGen ExAC gnomAD
CA1006511 rs751212229	182	G>S		No	ClinGen ExAC gnomAD
CA1006510 rs763667741	183	E>K		No	ClinGen ExAC TOPMed gnomAD
rs202157291 CA341638978	185	G>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1006507 rs202157291	185	G>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA341638981 rs147968487 CA1006508	185	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA1006509 rs147968487	185	G>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs776587023 CA1006505	186	G>E		No	ClinGen ExAC TOPMed gnomAD
rs751997684	187	A>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs751997684	187	A>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA341638952 rs1384351247	187	A>T		No	ClinGen TOPMed gnomAD
CA341638934 rs772217983	188	R>C		No	ClinGen ExAC TOPMed gnomAD
CA1006499 rs772217983	188	R>G		No	ClinGen ExAC TOPMed gnomAD
CA1006498 COSM1560097 rs371956554	188	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	189	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779118033 CA1006497	189	E>G		No	ClinGen ExAC gnomAD
rs1163421084 CA341638928	189	E>K		No	ClinGen gnomAD
rs755153278 CA1006496	195	G>D		No	ClinGen ExAC gnomAD
CA341638832 rs1557908404	196	Q>E		No	ClinGen Ensembl
rs749808777 CA1006495	197	P>L		No	ClinGen ExAC gnomAD
CA341638794 rs1557908395	198	Q>R		No	ClinGen Ensembl
rs562140489 CA1006494	199	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA341638756 rs1557908385	201	G>D		No	ClinGen Ensembl
CA1006493 rs543906848	202	R>C		No	ClinGen ExAC TOPMed gnomAD
rs751736006 CA1006492	202	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA28891110 rs112513430	203	R>G		No	ClinGen gnomAD
CA1006490 rs197434	204	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	205	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1006488 rs764694872	205	A>S		No	ClinGen ExAC TOPMed gnomAD
CA341638707 rs764694872	205	A>T		No	ClinGen ExAC TOPMed gnomAD
CA341638674 rs1266917083	208	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs759108603 CA1006487	210	I>M		No	ClinGen ExAC gnomAD
CA341638584 rs1338874348	214	F>V		No	ClinGen TOPMed
rs141928251 CA341638534	216	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs139428718 CA1006484	216	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA1006485 rs141928251	216	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	217	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1006483 rs772906395	217	S>T		No	ClinGen ExAC gnomAD
CA1006480 rs199796927	219	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs761913751 CA1006481	219	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs768843965 CA1006479	222	R>G		No	ClinGen ExAC gnomAD
rs373660885 CA1006478	222	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1224843408 CA341638399	224	R>Q		No	ClinGen TOPMed
rs780642863 CA1006477	224	R>W		No	ClinGen ExAC TOPMed gnomAD
rs770237328 CA341638381	226	L>M		No	ClinGen ExAC TOPMed gnomAD
rs1209825822 CA341638374	226	L>P		No	ClinGen TOPMed
TCGA novel	229	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1190964897 CA341638305	231	G>R		No	ClinGen gnomAD
CA1006474 rs781388407	232	W>*		No	ClinGen ExAC TOPMed gnomAD
CA1006475 rs746193336	232	W>R		No	ClinGen ExAC gnomAD
CA341638269 rs1571589364	233	V>G		No	ClinGen Ensembl
CA1006472 rs199713597	233	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA1006473 rs199713597	233	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA1006471 rs199986760	235	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1006470 rs754424975	236	M>I		No	ClinGen ExAC gnomAD
rs1557908273 CA341638225	237	V>I		No	ClinGen Ensembl
CA1006469 rs201410445	238	P>A		No	ClinGen ExAC TOPMed gnomAD
rs1256065444 COSM1491625 CA341638203	239	E>K	kidney Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA341638176 rs201867839	240	S>F		No	ClinGen gnomAD
CA28890985 rs200242479	240	S>T		No	ClinGen gnomAD
rs201867839 CA28890973	240	S>Y		No	ClinGen gnomAD
CA1006467 rs533938052	241	R>*		No	ClinGen 1000Genomes ExAC gnomAD
rs750418454 CA1006466	241	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA341638157 rs1571589315	242	T>P		No	ClinGen Ensembl
rs149166258 CA1006464	243	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs774657384 CA1006463	244	R>C		No	ClinGen ExAC TOPMed gnomAD
CA1006462 rs769005492	244	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs774657384 CA341638132	244	R>S		No	ClinGen ExAC TOPMed gnomAD
CA341638108 rs1423754829	245	S>L		No	ClinGen gnomAD
CA341638103 rs1476864685	246	Q>E		No	ClinGen TOPMed gnomAD
CA341638095 rs146284231	246	Q>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1006459 rs146284231	246	Q>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1274975411 CA341638075	248	V>F		No	ClinGen TOPMed
CA341638070 rs1571589267	248	V>G		No	ClinGen Ensembl
rs781756669 CA1006457	251	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs746329340 CA341638036	251	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA1006456 rs201711071	252	S>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA341638021 CA1006455 rs747384854	252	S>R		No	ClinGen ExAC gnomAD
rs948036512 CA28890911	256	G>D		No	ClinGen TOPMed
CA28890912 rs374920750	256	G>S		No	ClinGen TOPMed gnomAD
CA341637942 rs916564929	263	P>A		No	ClinGen TOPMed gnomAD
rs916564929 CA28890889	263	P>S		No	ClinGen TOPMed gnomAD
CA1006447 rs185732568	266	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs371003046 CA1006446	267	E>Q		No	ClinGen ESP ExAC gnomAD
rs1167774937 CA341637907	268	H>Q		No	ClinGen TOPMed
CA1006444 COSM201275 rs560783748	270	R>*	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA1006443 rs763243478	270	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA341637894 rs1173882817	271	G>W		No	ClinGen gnomAD
CA1006442 rs775894139	272	E>G		No	ClinGen ExAC gnomAD
rs1378278781 CA341637876	273	N>K		No	ClinGen gnomAD
rs1440285665 CA341637864	275	P>L		No	ClinGen gnomAD
CA1006437 rs771470532	276	T>I		No	ClinGen ExAC TOPMed gnomAD
CA28890833 rs928346948	276	T>P		No	ClinGen Ensembl
rs759002690	276	T>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA1006436 rs747331820	277	S>R		No	ClinGen ExAC gnomAD
rs965580113 CA28890825	278	C>R		No	ClinGen TOPMed gnomAD
CA1006435 rs773546549	278	C>Y		No	ClinGen ExAC TOPMed gnomAD
CA1006434 rs772468594	279	P>L		No	ClinGen ExAC TOPMed gnomAD
CA341637837 rs1291241815	280	K>R		No	ClinGen TOPMed
rs748938881 CA1006432	282	L>V		No	ClinGen ExAC gnomAD
rs1450729925 CA341637819	283	E>G		No	ClinGen TOPMed gnomAD
CA341637811 rs1557908100	284	H>R		No	ClinGen Ensembl
rs1187381057 CA341637802	285	S>L		No	ClinGen gnomAD
rs1312899005 CA341637797	286	P>R		No	ClinGen gnomAD
CA341637800 rs1360420424	286	P>T		No	ClinGen TOPMed gnomAD
rs112881255 COSM1294726 CA28890773	287	S>L	Variant assessed as Somatic; impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA1006430 rs540360673	287	S>P		No	ClinGen 1000Genomes ExAC gnomAD
CA28890765 rs912269371	288	G>E		No	ClinGen TOPMed gnomAD
CA1006429 rs755521337	289	F>S		No	ClinGen ExAC gnomAD
CA341637775 rs1396049532	290	D>G		No	ClinGen TOPMed
rs1396049532 CA341637774	290	D>V		No	ClinGen TOPMed
CA1006428 rs745388675	291	I>V		No	ClinGen ExAC gnomAD
rs1180055100 CA341637752	293	T>I		No	ClinGen gnomAD
CA1006426 rs757284319	294	A>V		No	ClinGen ExAC gnomAD
rs758334663 CA1006423	295	V>A		No	ClinGen ExAC TOPMed gnomAD
CA1006424 rs376544641	295	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA341637746 rs376544641	295	V>L		No	ClinGen ESP ExAC TOPMed gnomAD

No associated diseases with Q9NTI7

1 regional properties for Q9NTI7

Type	Name	Position	InterPro Accession
domain	FAM212 domain	120 - 175	IPR029267

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name	Definition
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein serine/threonine kinase inhibitor activity	Binds to and stops, prevents or reduces the activity of a protein serine/threonine kinase.

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MTMESREMDC	YLRRLKQELM	SMKEVGDGLQ	DQMNCMMGAL	QELKLLQVQT	ALEQLEISGG
70	80	90	100	110	120
GPVPGSPEGP	RTQCEHPCWE	GGRGPARPTV	CSPSSQPSLG	SSTKFPSHRS	VCGRDLAPLP
130	140	150	160	170	180
RTQPHQSCAQ	QGPERVEPDD	WTSTLMSRGR	NRQPLVLGDN	VFADLVGNWL	DLPELEKGGE
190	200	210	220	230	240
KGETGGAREP	KGEKGQPQEL	GRRFALTANI	FKKFLRSVRP	DRDRLLKEKP	GWVTPMVPES
250	260	270	280	290
RTGRSQKVKK	RSLSKGSGHF	PFPGTGEHRR	GENPPTSCPK	ALEHSPSGFD	INTAVWV