Q9NJU9

PR
Gene name
CDPK3
Protein name
Calcium-dependent protein kinase 3
Names
PfCDPK3
Species
Plasmodium falciparum (isolate 3D7)
KEGG Pathway
pfa:PF3D7_0310100
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-123 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

277-281 (Activation loop from InterPro)

Target domain

118-373 (Protein kinase domain)

Relief mechanism

Assay

258-266 (Activation loop from InterPro)

Target domain

118-373 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

2 structures for Q9NJU9

Entry ID Method Resolution Chain Position Source
3K21 X-ray 115 A A 388-560 PDB
AF-Q9NJU9-F1 Predicted AlphaFoldDB

No variants for Q9NJU9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9NJU9

No associated diseases with Q9NJU9

3 regional properties for Q9NJU9

Type Name Position InterPro Accession
domain Protein kinase domain 349 - 640 IPR000719
active_site Serine/threonine-protein kinase, active site 469 - 481 IPR008271
domain Cyclin-dependent kinase 11/PITSLRE, catalytic domain 343 - 640 IPR045267

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calcium ion binding Binding to a calcium ion (Ca2+).
calcium-dependent protein serine/threonine kinase activity Calcium-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate.
calmodulin binding Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
calmodulin-dependent protein kinase activity Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.

5 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNDLIIKNNK KGSCDVIIKY KCKKSDENIK RRKSSHKYIK NKSVVLGRSI MTNKKEKLKG
70 80 90 100 110 120
ALKYKGSKKE IKICNKKSMI KNDKDENTTL KSMKSDNFKF SRRGFILSFT GNLEDFYNLS
130 140 150 160 170 180
KEPLGKGTYG CVYKATDKLL KISRAVKVVS KKKLKNIPRF RQEIDIMKNL DHPNVVKLLE
190 200 210 220 230 240
TFEDSNQIYL VMELCTGGEL FDKIVKKGCF VETFASFIMK QIFSVLNYLH IRNICHRDIK
250 260 270 280 290 300
PENFLFYDMT PESLIKIIDF GLASYFTHNN YEMKTKAGTP YYVAPQVLTG SYNYKCDMWS
310 320 330 340 350 360
SGVLFYILLC GYPPFFGESD HEILSMVKKG KYQFKGKEWN NISEEAKDLI KRCLTMDADK
370 380 390 400 410 420
RICASEALQH PWFKKKKYAF NMDMKMDIHV LENFKNYGLL LKFQKLAMTI IAQQSNDYDV
430 440 450 460 470 480
EKLKSTFLVL DEDGKGYITK EQLKKGLEKD GLKLPYNFDL LLDQIDSDGS GKIDYTEFIA
490 500 510 520 530 540
AALDRKQLSK KLIYCAFRVF DVDNDGEITT AELAHILYNG NKKGNITQRD VNRVKRMIRD
550 560
VDKNNDGKID FHEFSEMMKL KF