Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9N2A2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9N2A2-F1 | Predicted | AlphaFoldDB |
No variants for Q9N2A2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9N2A2 | |||||
No associated diseases with Q9N2A2
1 regional properties for Q9N2A2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPCR, rhodopsin-like, 7TM | 85 - 544 | IPR017452 |
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| postsynaptic membrane | A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| acetylcholine binding | Binding to acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. |
| G protein-coupled acetylcholine receptor activity | Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| G protein-coupled acetylcholine receptor signaling pathway | A G protein-coupled receptor signaling pathway initiated by a ligand binding to an acetylcholine receptor on the surface of a target cell, and ends with regulation of a downstream cellular process, e.g. transcription. |
| positive regulation of smooth muscle contraction | Any process that activates or increases the frequency, rate or extent of smooth muscle contraction. |
| saliva secretion | The regulated release of saliva from the salivary glands. In man, the saliva is a turbid and slightly viscous fluid, generally of an alkaline reaction, and is secreted by the parotid, submaxillary, and sublingual glands. In the mouth the saliva is mixed with the secretion from the buccal glands. In man and many animals, saliva is an important digestive fluid on account of the presence of the peculiar enzyme, ptyalin. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTLHSNSTTS | PLFPNISSSW | IHSPSDAGLP | RGTVTHFGSY | NVSRAAGNFS | SPNGPTDDPL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GGHTVWQVVF | IAFLTGILAL | VTIIGNILVI | VSFKVNKQLK | TVNNYFLLSL | ACADLIIGVI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SMNLFTTYII | MNRWALGNLA | CDLWLAIDYV | ASNASVMNLL | VISFDRYFSI | TRPLTYRAKR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TTKRAGVMIG | LAWVISFVLW | APAILFWQYF | VGKRTVPPGE | CFIQFLSEPT | ITFGTAIAAF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YMPVTIMTIL | YWRIYKETEK | RTKELAGLQA | SGTEAETENF | VHPTGSSRSC | SSYELQQQSM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KRANRRKYGR | CHFWFTTKSW | KPSSEQMDQD | HSSSDSWNNN | DAAASLENSA | SSDEEDIGSE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TRAIYSIVLK | LPGHSTILNS | TKLPSSDNLQ | VPEEELGMVD | LERKANKLQA | QKSVDDGGSF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PKSFSKLPIQ | LESAVDTAKT | ADVNSSVGKT | TATLPLSFKE | ATLAKRFALK | TRSQITKRKR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| MSLVKEKKAA | QTLSAILLAF | IITWTPYNIM | VLVNTFCDSC | IPKTFWNLGY | WLCYINSTVN |
| 550 | 560 | 570 | 580 | ||
| PVCYALCNKT | FRTTFKMLLL | CQCDKKKRRK | QQYQQRQSVI | FHKRAPEQAL |