Q9N0V3

PR
Gene name
ABCB11
Protein name
Bile salt export pump
Names
ATP-binding cassette sub-family B member 11, Sister of P-glycoprotein
Species
Oryctolagus cuniculus (Rabbit)
KEGG Pathway
ocu:100008767
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-64 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9N0V3

Entry ID Method Resolution Chain Position Source
AF-Q9N0V3-F1 Predicted AlphaFoldDB

No variants for Q9N0V3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9N0V3

No associated diseases with Q9N0V3

7 regional properties for Q9N0V3

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 420 - 656 IPR003439-1
domain ABC transporter-like, ATP-binding domain 1078 - 1316 IPR003439-2
domain AAA+ ATPase domain 447 - 633 IPR003593-1
domain AAA+ ATPase domain 1105 - 1299 IPR003593-2
domain ABC transporter type 1, transmembrane domain 62 - 385 IPR011527-1
domain ABC transporter type 1, transmembrane domain 756 - 1043 IPR011527-2
conserved_site ABC transporter-like, conserved site 559 - 573 IPR017871

Functions

Description
EC Number
Subcellular Localization
  • Apical cell membrane ; Multi-pass membrane protein
  • Recycling endosome membrane ; Multi-pass membrane protein
  • Endosome
  • Cell membrane ; Multi-pass membrane protein
  • Internalized at the canalicular membrane through interaction with the adapter protein complex 2 (AP-2)
  • At steady state, localizes in the canalicular membrane but is also present in recycling endosomes
  • ABCB11 constantly and rapidly exchanges between the two sites through tubulo-vesicles carriers that move along microtubules
  • Microtubule-dependent trafficking of ABCB11 is enhanced by taurocholate and cAMP and regulated by STK11 through a PKA-mediated pathway
  • Trafficking of newly synthesized ABCB11 through endosomal compartment to the bile canalicular membrane is accelerated by cAMP but not by taurocholate (By similarity)
  • Cell membrane expression is up-regulated by short- and medium-chain fatty acids (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
cell surface The external part of the cell wall and/or plasma membrane.
endosome A vacuole to which materials ingested by endocytosis are delivered.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
intracellular canaliculus An apical plasma membrane part that forms a narrow enfolded luminal membrane channel, lined with numerous microvilli, that appears to extend into the cytoplasm of the cell. A specialized network of intracellular canaliculi is a characteristic feature of parietal cells of the gastric mucosa in vertebrates.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
recycling endosome An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.
recycling endosome membrane The lipid bilayer surrounding a recycling endosome.

5 GO annotations of molecular function

Name Definition
ABC-type bile acid transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(in) + ATP + H2O -> bile acid(out) + ADP + phosphate.
ABC-type xenobiotic transporter activity Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
bile acid transmembrane transporter activity Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
canalicular bile acid transmembrane transporter activity The directed movement of bile acid and bile salts out of a hepatocyte and into the bile canaliculus by means of an agent such as a transporter or pore. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.

14 GO annotations of biological process

Name Definition
bile acid and bile salt transport The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
bile acid metabolic process The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
canalicular bile acid transport Enables the transfer of bile acid from one side of a hepatocyte plasma membrane into a bile canaliculus. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
cholesterol homeostasis Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
lipid homeostasis Any process involved in the maintenance of an internal steady state of lipid within an organism or cell.
phospholipid homeostasis Any process involved in the maintenance of an internal steady state of phospholipid within an organism or cell.
positive regulation of bile acid secretion Any process that activates or increases the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue.
protein ubiquitination The process in which one or more ubiquitin groups are added to a protein.
regulation of bile acid metabolic process Any process that modulates the frequency, rate or extent of bile acid metabolic process.
regulation of fatty acid beta-oxidation Any process that modulates the frequency, rate or extent of fatty acid bbeta-oxidation.
xenobiotic export from cell The directed movement of a xenobiotic from a cell, into the extracellular region. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
xenobiotic metabolic process The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
xenobiotic transmembrane transport The process in which a xenobiotic, a compound foreign to the organim exposed to it, is transported across a membrane. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSDSVILRSV KKFGEENHGF ESDGSYNNEK KSRLQDKKKS DSVRIGFFQL FRFSSWTDIW
70 80 90 100 110 120
LMCMGSLCAC IHGIAQPGVL LIFGTMTDVF IDYDTELQEL KIPGKACVNN TIVWINSSLN
130 140 150 160 170 180
QNVTNGTRCG LLDIESEMIR FAGYYAGIGI AVLTTGYIQI CFWGIAAAHQ IQKMRKSYFR
190 200 210 220 230 240
KIMRMGIGWV DCNSVGKLNT PFSVDFNKIN DSSADQLAIF IQGMTSPIFG FLVGFSQWWK
250 260 270 280 290 300
LTLVIISVSP LIGLGAAIIG LSVSKFTDYE LKAYAKAGSV ADEVISSMRT VAAFGGEKKE
310 320 330 340 350 360
VERYEKNLVF AQRWGIRKGI VMGFFTGYMW CLIFFCYALA FWYGSKLVLE EGEYSPGALV
370 380 390 400 410 420
QIFLSVIIGA LNLGNASPCL EAFAAGRAAA SSIFETIDRK PIIDCMSEDG YKLERIKGEI
430 440 450 460 470 480
EFHNVTFHYP SRPEVKILNN LSMVIKPGEM TALVGPSGAG KSTALQLIHR FYGPTEGMVT
490 500 510 520 530 540
VESHDIRSSH IQWLRNQIGI VEQEPVLFFH TIAEKIRYGR EDATMEDLIQ AAKEANAYNF
550 560 570 580 590 600
IMDLPQQFDT LVGEGGGQMS GGQKQRVAIA RALIRNPKIL LLDMATSALD NESEAMVQEA
610 620 630 640 650 660
LSKTQHGHTI VSVAHRPATI RTADVIIGCE HGAAVERGTE EELLERKGVY FALVTLQSQR
670 680 690 700 710 720
NQGDQEENEK DATEDDIPEK TFSRGNYQDS LRASLRQRSK SQLSYLAHEP PMAVEDHKST
730 740 750 760 770 780
HEEDRKDKDL PAQEDIEPAS VRRIMKLNAP EWPYMLLGSM GAAVNGAVTP LYAFLFSQIL
790 800 810 820 830 840
GTFSLPDKEE QRSQINGICL LFVTLGCVSF FTQFLQGYTF AKSGELLTKR LRKFGFRAML
850 860 870 880 890 900
GQDIGWFDDL RNSPGALTTR LATDASQVQG ATGSQIGMMV NSFTNVTVAM IIAFLFSWKL
910 920 930 940 950 960
TLGIVCFFPF LALSGALQTK MLTGFASRDK QALEKAGQIT SEALSNIRTV AGIGKERKFI
970 980 990 1000 1010 1020
ETFEAELEKP YKMAIKKANV YGLCFGFSQC ITFIANSASY RYGGYLISNE GLHFSYVFRV
1030 1040 1050 1060 1070 1080
ISAVVLSATA LGRASSYTPS YAKAKISAAR FFQLLDRQPP INVYSSAGEK WDNFQGKIDF
1090 1100 1110 1120 1130 1140
VDCKFTYPSR PDIQVLNGLS VSMSPRQTLA FVGSSGCGKS TSIQLLERFY DPDHGKVMID
1150 1160 1170 1180 1190 1200
GHDSRKVNIQ FLRSNIGIVS QEPVLFACSI KDNIKYGDNT QEIPMERIIA AAKKAQVHDF
1210 1220 1230 1240 1250 1260
VMSLPEKYET NVGSQGSQLS RGEKQRIAIA RAIVRDPKIL LLDEATSALD TESEKTVQVA
1270 1280 1290 1300 1310 1320
LDKAREGRTC IVIAHRLSTI QNSDIIAVMS QGMVIEKGTH EELMVQKGAY YKLVTTGSPI
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