Q9N0E1
Gene name |
AACS (QccE-10783, QccE-14415, QflA-13650) |
Protein name |
Acetoacetyl-CoA synthetase |
Names |
|
Species |
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) |
KEGG Pathway |
|
EC number |
6.2.1.16: Acid--thiol ligases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9N0E1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9N0E1-F1 | Predicted | AlphaFoldDB |
No variants for Q9N0E1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9N0E1 | |||||
No associated diseases with Q9N0E1
6 regional properties for Q9N0E1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | ABC transporter-like, ATP-binding domain | 481 - 716 | IPR003439-1 |
| domain | ABC transporter-like, ATP-binding domain | 1288 - 1521 | IPR003439-2 |
| domain | AAA+ ATPase domain | 509 - 693 | IPR003593-1 |
| domain | AAA+ ATPase domain | 1318 - 1498 | IPR003593-2 |
| domain | ABC-2 type transporter, transmembrane domain | 32 - 419 | IPR013525-1 |
| domain | ABC-2 type transporter, transmembrane domain | 970 - 1219 | IPR013525-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.2.1.16 | Acid--thiol ligases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| acetoacetate-CoA ligase activity | Catalysis of the reaction: acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate + H(+). |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| fatty acid metabolic process | The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSKEERPGRE | EILECQVMWE | PDSKKNTQMD | RFRAAVGAAC | GLALENYDDL | YRWSVESYSD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FWAEFWKFSG | IVFSRAYDEV | VDTSKGIADV | PEWFKGSRLN | YAENLLRHKE | NDRVALYVAR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EGKEEIVKVT | FEELRQEVAL | FAAAMRKMGV | KKGDRVVGYL | PNSEHAVEAM | LAAASIGAIW |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SSTSPDFGVN | GVLDRFSQIQ | PKLIFSVEAV | VYNGKEHSHM | EKLQQVVKGL | PDLKKVVVIP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YVSSREKIDL | SKIPNSVFLD | DFLATGTSEQ | APQLEFEQLP | FSHPLFIMFS | SGTTGAPKCM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VHSAGGTLIQ | HLKEHLLHGN | MTSSDILLCY | TTAGWMMWNW | MVSILATGAA | MVLYDGSPLV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PTPNVLWDLV | DRIGITVLVT | GAKWLSVLEE | KAMKPVETHS | LQMLHTILST | GSPLKAQSYE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YVYRCIKSSI | LLGSISGGTD | IISCFMGHNF | SLPVYKGEIQ | ARNLGMAVEA | WNEEGKAVWG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ESGELVCTKP | IPCQPTHFWN | DENGSKYRKA | YFSKFPGIWA | HGDYCRINPK | TGGIIMLGRS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| DGTLNPNGVR | FGSSEIYNIV | ESFEEVEDSL | CVPQYNKFRE | ERVILFLKMA | SGHAFQPDLV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KRIRDAIRVG | LSARHVPSLI | LETKGIPYTL | NGKKVEVAVK | QIIAGKAVEQ | GGAFSNPETL |
| 670 | |||||
| DLYRDIPELQ | GF |