Q9MZT2

PR
Gene name
SLC28A1 (CNT1)
Protein name
Sodium/nucleoside cotransporter 1
Names
Concentrative nucleoside transporter 1, CNT 1, Na(+)/nucleoside cotransporter 1, Sodium-coupled nucleoside transporter 1, Solute carrier family 28 member 1
Species
Oryctolagus cuniculus (Rabbit)
KEGG Pathway
ocu:100009595
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-88 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9MZT2

Entry ID Method Resolution Chain Position Source
AF-Q9MZT2-F1 Predicted AlphaFoldDB

No variants for Q9MZT2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9MZT2

No associated diseases with Q9MZT2

3 regional properties for Q9MZT2

Type Name Position InterPro Accession
domain Concentrative nucleoside transporter N-terminal domain 178 - 250 IPR002668
domain Nucleoside transporter/FeoB GTPase, Gate domain 260 - 355 IPR011642
domain Concentrative nucleoside transporter C-terminal domain 362 - 583 IPR011657

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Apical cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
cytidine transmembrane transporter activity Enables the transfer of cytidine, cytosine riboside, from one side of a membrane to the other.
nucleoside:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + Na+(out) = nucleoside(in) + Na+(in).
uridine transmembrane transporter activity Enables the transfer of uridine, uracil riboside, from one side of a membrane to the other.

2 GO annotations of biological process

Name Definition
cytidine transport The directed movement of cytidine, cytosine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
uridine transport The directed movement of uridine, uracil riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEKASGRKSL ALSTAENGIE NAGLELTEEG INSEQTRRME VQGHSLSDDV RPATHQRSYL
70 80 90 100 110 120
QPLTKARTFC QRHASLFKKI LLGLLCLAYA AYFLAACILD FQRALALFVI TCLVILVLLL
130 140 150 160 170 180
HFLKKFLGKK LTRCLKPFKN SQLRLWIKRV FAGVSLVGLI LWLALDTAQR PEQLISFAGI
190 200 210 220 230 240
CMFVLILFAC SKHHSAVSWR TVFWGLGLQF VFGLLVIRTD PGFIAFQWLG DQVQIFLAYT
250 260 270 280 290 300
VAGSSFVLGD TLVNDVFAFQ SLPIIIFFGC VMSILYYLGL VQWVVQKIAW FLQVTMRTTA
310 320 330 340 350 360
TETLAVAGNI FVGMTEAPLL IRPYLADLTL SEIHAVMTSG FATISGTVLG AFISFGIDAS
370 380 390 400 410 420
SLISASVMGA PCALALSKLV YPEEEESKFK SKEGVKLPRG KESNVLEAAS NGATDAIALV
430 440 450 460 470 480
ANVAANLVAF LAVLAFINAA LSWLGELVDI QGLTFQVICS YILRPMVYMM GVEWTDCPMV
490 500 510 520 530 540
AEMVGIKFFT NEFVAYQQLS QYKKKRLSGM EEWIDGQKQW ISVRAEVITT FSLCGFANLS
550 560 570 580 590 600
SIGITLGGLT SMVPHRKSDL SKVVIRALFT GSCVSFISAC VAGILYVPRG AETDCVSFLS
610 620 630 640 650
TSFTNRSYET YVCCRELFQN TYLNGTNPPS FSGAWEDKAF SAMALANCCG FYNNTVCA