AiPD: Autoinhibited Protein Database

Gene name	TPP2 (At1g06870, F4H5.6)
Protein name	Probable thylakoidal processing peptidase 2, chloroplastic
Names	Signal peptidase I-2
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT1G06870
EC number	3.4.21.89: Serine endopeptidases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

25-103 (Predicted disordered autoinhibitory region) PR

25-103 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9M9Z2-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH01019892	31	R>S	No	1000Genomes
tmp_1_2108934_G_C	35	E>Q	No	1000Genomes
ENSVATH00009390	40	P>S	No	1000Genomes
ENSVATH04532071	48	I>T	No	1000Genomes
ENSVATH00009391	53	D>E	No	1000Genomes
ENSVATH01019893	55	S>P	No	1000Genomes
ENSVATH00009392	66	G>S	No	1000Genomes
ENSVATH13858881	67	P>S	No	1000Genomes
ENSVATH10715762	68	R>C	No	1000Genomes
ENSVATH00009393	83	I>L	No	1000Genomes
tmp_1_2109094_G_T	88	C>F	No	1000Genomes
ENSVATH01019896	88	C>S	No	1000Genomes
ENSVATH04532073	92	L>V	No	1000Genomes
ENSVATH10715763	97	I>F	No	1000Genomes
ENSVATH00009394	103	T>S	No	1000Genomes
ENSVATH01019897	105	A>P	No	1000Genomes
ENSVATH04532074	106	P>S	No	1000Genomes
ENSVATH10715764	122	S>F	No	1000Genomes
tmp_1_2109207_C_A	126	P>T	No	1000Genomes
ENSVATH01019898	130	G>D	No	1000Genomes
tmp_1_2109276_G_A	149	V>I	No	1000Genomes
ENSVATH04532076	150	D>N	No	1000Genomes
ENSVATH00009395	159	K>Q	No	1000Genomes
ENSVATH13858883	193	A>G	No	1000Genomes
ENSVATH01019900	199	L>F	No	1000Genomes
ENSVATH00009397	226	I>M	No	1000Genomes
tmp_1_2109763_G_A	230	V>I	No	1000Genomes
tmp_1_2109923_T_G	254	H>Q	No	1000Genomes
ENSVATH04532083	278	D>N	No	1000Genomes
tmp_1_2110210_C_A	289	A>E	No	1000Genomes
tmp_1_2110209_G_A	289	A>T	No	1000Genomes
ENSVATH01019908	291	D>A	No	1000Genomes
ENSVATH13858884	322	F>V	No	1000Genomes
ENSVATH10715881	323	D>N	No	1000Genomes
ENSVATH10715882	336	I>V	No	1000Genomes
tmp_1_2110629_T_C	364	V>A	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Peptidase S26	187 - 344	IPR019533
active_site	Peptidase S26A, signal peptidase I, serine active site	212 - 219	IPR019756
conserved_site	Peptidase S26A, signal peptidase I, conserved site	311 - 324	IPR019758

		Description
EC Number	3.4.21.89	Serine endopeptidases
Subcellular Localization	Plastid, chloroplast thylakoid membrane; Single-pass membrane protein	located in the non-appressed lamellae of the thylakoid network
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
chloroplast thylakoid membrane	The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana.
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

Name	Definition
serine-type endopeptidase activity	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

Name	Definition
signal peptide processing	The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell.
thylakoid membrane organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the thylakoid membrane.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins