Q9M841
Gene name |
PEX12 (APM4, At3g04460, T27C4.11) |
Protein name |
Peroxisome biogenesis protein 12 |
Names |
Peroxin-12, AtPEX12, Pex12p, Protein ABERRANT PEROXISOME MORPHOLOGY 4 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G04460 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9M841
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9M841-F1 | Predicted | AlphaFoldDB |
16 variants for Q9M841
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_3_1186853_G_T | 39 | A>S | No | 1000Genomes | |
| tmp_3_1186857_T_C | 40 | L>S | No | 1000Genomes | |
| ENSVATH05769774 | 70 | T>I | No | 1000Genomes | |
| ENSVATH13868379 | 132 | H>Q | No | 1000Genomes | |
| ENSVATH05769781 | 156 | D>Y | No | 1000Genomes | |
| ENSVATH05769782 | 163 | G>R | No | 1000Genomes | |
| tmp_3_1187470_C_G | 183 | Q>E | No | 1000Genomes | |
| tmp_3_1187483_A_G | 187 | K>R | No | 1000Genomes | |
| ENSVATH05769783 | 190 | K>T | No | 1000Genomes | |
| tmp_3_1187516_G_T | 198 | W>L | No | 1000Genomes | |
| tmp_3_1187521_C_T | 200 | H>Y | No | 1000Genomes | |
| ENSVATH10488614 | 222 | Y>S | No | 1000Genomes | |
| tmp_3_1188155_A_T | 265 | L>F | No | 1000Genomes | |
| tmp_3_1188314_G_C | 279 | V>L | No | 1000Genomes | |
| ENSVATH10488643 | 382 | S>N | No | 1000Genomes | |
| tmp_3_1189090_C_A | 393 | T>N | No | 1000Genomes |
No associated diseases with Q9M841
1 regional properties for Q9M841
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Pex, N-terminal | 21 - 303 | IPR006845 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of peroxisomal membrane | The component of the peroxisomal membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| peroxisomal importomer complex | A protein complex responsible for transporting proteins into the peroxisomal matrix. An example of this complex is Pex14 found in S. cerevisae which has 9 core components and 12 transient interaction partners. |
| peroxisomal membrane | The lipid bilayer surrounding a peroxisome. |
| peroxisome | A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein C-terminus binding | Binding to a protein C-terminus, the end of a peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. |
| ubiquitin-protein transferase activity | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. |
| zinc ion binding | Binding to a zinc ion (Zn). |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| embryonic morphogenesis | The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants. |
| fatty acid beta-oxidation | A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). |
| peroxisome organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. |
| protein import into peroxisome matrix | The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix. |
| protein monoubiquitination | Addition of a single ubiquitin group to a protein. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O00623 | PEX12 | Peroxisome assembly protein 12 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLFQVGGEGT | RPTFFEMAAA | QQLPASLRAA | LTYSLGVFAL | RRSFLHKILD | YEDEFFAALM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LILEGHSLRT | TDGSFAESLY | GLRRKSARLR | LRKDSARKDS | SEEVQHSGLE | KRQRILSVVF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LVVLPYFKSK | LHAIYNKERE | ARLRESLWGA | EDQGFDEADF | FTGDDSIVSR | EPSGNEELSV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RVQLATKIKK | FIAVCYPWIH | ASSEGLSFTY | QLLYLLDATG | FYSLGLQALG | IQVCRATGQE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LMDTSSRISK | IRNHERERLR | GPPWLKTVQG | ALLSCSYAVL | DYAQTGLIAA | VFIFKMMEWW |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YQSAEERLSA | PTVYPPPPPP | PAPKMAKEGI | PLPPDRSLCA | LCLQKRANPS | VVTVSGFVFC |
| 370 | 380 | 390 | |||
| YSCVFKYVSK | YKRCPVTLIP | ASVDQIRRLF | QDT |