Q9M591
Gene name |
CRD1 (ACSF, AT103, CHL27, ZIP) |
Protein name |
Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase, chloroplastic |
Names |
Mg-protoporphyrin IX monomethyl ester oxidative cyclase, Copper response defect 1 protein, Dicarboxylate diiron protein, AtZIP, MPE-cyclase |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G56940 |
EC number |
1.14.13.81: With NADH or NADPH as one donor, and incorporation of one atom of oxygen |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9M591
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9M591-F1 | Predicted | AlphaFoldDB |
9 variants for Q9M591
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH06329105 | 21 | N>T | No | 1000Genomes | |
| tmp_3_21076682_G_T | 30 | R>L | No | 1000Genomes | |
| ENSVATH02515870 | 37 | M>V | No | 1000Genomes | |
| tmp_3_21076739_C_T | 49 | A>V | No | 1000Genomes | |
| tmp_3_21076938_G_T | 115 | K>N | No | 1000Genomes | |
| ENSVATH14445366 | 201 | A>V | No | 1000Genomes | |
| ENSVATH14445368 | 312 | T>S | No | 1000Genomes | |
| tmp_3_21078097_A_T | 353 | Y>F | No | 1000Genomes | |
| tmp_3_21078121_A_T | 361 | E>V | No | 1000Genomes |
No associated diseases with Q9M591
Functions
| Description | ||
|---|---|---|
| EC Number | 1.14.13.81 | With NADH or NADPH as one donor, and incorporation of one atom of oxygen |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast | A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. |
| chloroplast envelope | The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space. |
| chloroplast inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the chloroplast envelope; also faces the chloroplast stroma. |
| chloroplast thylakoid | Sac-like membranous structures (cisternae) in a chloroplast combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. An example of this component is found in Arabidopsis thaliana. |
| chloroplast thylakoid membrane | The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity | Catalysis of the reaction: magnesium protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 H+ + 3 O2 = divinylprotochlorophyllide + 3 NADP+ + 5 H2O. |
| metal ion binding | Binding to a metal ion. |
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| chlorophyll biosynthetic process | The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. |
| chloroplast organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chloroplast. |
| photosynthesis | The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. |
| regulation of tetrapyrrole metabolic process | Any process that modulates the frequency, rate or extent of tetrapyrrole metabolic process. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6SJV8 | CRD1 | Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase, chloroplastic | Gossypium hirsutum (Upland cotton) (Gossypium mexicanum) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAEMALVKP | ISKFSSPKLS | NPSKFLSGRR | FSTVIRMSAS | SSPPPPTTAT | SKSKKGTKKE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IQESLLTPRF | YTTDFEEMEQ | LFNTEINKNL | NEAEFEALLQ | EFKTDYNQTH | FVRNKEFKEA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ADKLQGPLRQ | IFVEFLERSC | TAEFSGFLLY | KELGRRLKKT | NPVVAEIFSL | MSRDEARHAG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FLNKGLSDFN | LALDLGFLTK | ARKYTFFKPK | FIFYATYLSE | KIGYWRYITI | YRHLKENPEF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QCYPIFKYFE | NWCQDENRHG | DFFSALMKAQ | PQFLNDWQAK | LWSRFFCLSV | YVTMYLNDCQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RTNFYEGIGL | NTKEFDMHVI | IETNRTTARI | FPAVLDVENP | EFKRKLDRMV | VSYEKLLAIG |
| 370 | 380 | 390 | 400 | ||
| ETDDASFIKT | LKRIPLVTSL | ASEILAAYLM | PPVESGSVDF | AEFEPNLVY |