AiPD: Autoinhibited Protein Database

Gene name	RBX1B (At3g42830, T21C14.50)
Protein name	RING-box protein 1b
Names	At-Rbx12, RBX1-1, RBX1b-At
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT3G42830
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-52 (Predicted disordered autoinhibitory region) PR

1-52 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9M2B0-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
tmp_3_14930671_G_A	3	S>F	No	1000Genomes
tmp_3_14930658_G_T	7	D>E	No	1000Genomes
ENSVATH00386514	11	G>D	No	1000Genomes
ENSVATH00386513	12	E>V	No	1000Genomes
ENSVATH00386512	14	S>F	No	1000Genomes
ENSVATH06138971	19	P>L	No	1000Genomes
ENSVATH06138970	21	S>T	No	1000Genomes
ENSVATH06138968	22	S>L	No	1000Genomes
ENSVATH06138969	22	S>T	No	1000Genomes
ENSVATH02366618	23	S>F	No	1000Genomes
ENSVATH02366617	28	R>Q	No	1000Genomes
tmp_3_14930588_A_T	31	L>I	No	1000Genomes
tmp_3_14930566_G_C	38	A>G	No	1000Genomes
ENSVATH02366616	38	A>T	No	1000Genomes
tmp_3_14930560_C_T	40	W>*	No	1000Genomes
ENSVATH06138967	41	A>P	No	1000Genomes
ENSVATH06138966	41	A>V	No	1000Genomes
ENSVATH02366610	46	V>I	No	1000Genomes
ENSVATH00386510	48	N>Y	No	1000Genomes
ENSVATH00386509	50	A>T	No	1000Genomes
ENSVATH06138960	56	I>T	No	1000Genomes
tmp_3_14930318_A_G	61	I>T	No	1000Genomes
tmp_3_14930310_G_C	64	L>V	No	1000Genomes
ENSVATH00386508	66	N>K	No	1000Genomes
tmp_3_14930294_C_A	69	S>I	No	1000Genomes
ENSVATH14274728	74	E>K	No	1000Genomes
tmp_3_14930273_G_A	76	T>I	No	1000Genomes
tmp_3_14930267_G_A	78	A>V	No	1000Genomes
ENSVATH12127393	93	R>K	No	1000Genomes
tmp_3_14929871_C_A	94	W>L	No	1000Genomes
ENSVATH00386501	100	V>L	No	1000Genomes
ENSVATH00386501	100	V>M	No	1000Genomes
tmp_3_14929845_G_C	103	L>V	No	1000Genomes
ENSVATH06138945	106	C>S	No	1000Genomes
ENSVATH02366585	106	C>Y	No	1000Genomes
ENSVATH02366584	107	E>D	No	1000Genomes
ENSVATH02366583	108	W>*	No	1000Genomes
ENSVATH06138944	112	K>R	No	1000Genomes
ENSVATH12127389	115	H>Q	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Calcipressin-2, RNA recognition motif	11 - 87	IPR034919

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cullin-RING ubiquitin ligase complex	Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
SCF ubiquitin ligase complex	A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).

Name	Definition
cullin family protein binding	Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3).
ubiquitin protein ligase activity	Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
zinc ion binding	Binding to a zinc ion (Zn).

Name	Definition
auxin-activated signaling pathway	The series of molecular signals generated by the binding of the plant hormone auxin to a receptor, and ending with modulation of a downstream cellular process, e.g. transcription.
jasmonic acid mediated signaling pathway	The series of molecular signals mediated by jasmonic acid.
protein ubiquitination	The process in which one or more ubiquitin groups are added to a protein.
response to auxin	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus.
response to jasmonic acid	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus.
ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins