Q9M092

PR
Gene name
WAKL17 (At4g31100, F6E21.20)
Protein name
Wall-associated receptor kinase-like 17
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT4G31100
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

67-157 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9M092

Entry ID Method Resolution Chain Position Source
AF-Q9M092-F1 Predicted AlphaFoldDB

65 variants for Q9M092

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH02946647 4 K>I No 1000Genomes
tmp_4_15123950_C_T 30 S>L No 1000Genomes
ENSVATH14319058 43 G>E No 1000Genomes
ENSVATH02946648 51 F>L No 1000Genomes
ENSVATH12329099 60 E>K No 1000Genomes
tmp_4_15124072_T_C 71 S>P No 1000Genomes
ENSVATH06806240 78 L>F No 1000Genomes
tmp_4_15124111_G_A 84 E>K No 1000Genomes
tmp_4_15124122_T_A 87 S>R No 1000Genomes
ENSVATH06806241 89 H>L No 1000Genomes
ENSVATH12329100 110 C>Y No 1000Genomes
ENSVATH12329101 129 F>L No 1000Genomes
ENSVATH06806242 130 V>I No 1000Genomes
tmp_4_15124290_C_A 143 S>R No 1000Genomes
ENSVATH00546275 167 S>L No 1000Genomes
tmp_4_15124368_C_A 169 S>R No 1000Genomes
ENSVATH06806243 175 F>L No 1000Genomes
tmp_4_15124421_C_T 187 A>V No 1000Genomes
ENSVATH08372212 191 T>A No 1000Genomes
ENSVATH06806244 198 M>I No 1000Genomes
tmp_4_15124534_A_G 225 N>D No 1000Genomes
ENSVATH12329102 228 K>N No 1000Genomes
ENSVATH00546276 229 S>L No 1000Genomes
tmp_4_15124556_G_T 232 S>I No 1000Genomes
ENSVATH14319059 240 L>* No 1000Genomes
tmp_4_15124624_C_T 255 Q>* No 1000Genomes
ENSVATH00546277 260 R>T No 1000Genomes
tmp_4_15124750_C_A 297 Q>K No 1000Genomes
ENSVATH06806247 298 S>G No 1000Genomes
ENSVATH12329103 301 C>Y No 1000Genomes
tmp_4_15124766_T_A 302 I>K No 1000Genomes
ENSVATH12329104 320 C>W No 1000Genomes
tmp_4_15124865_G_T 335 R>I No 1000Genomes
tmp_4_15125008_C_A 344 P>T No 1000Genomes
ENSVATH12329136 357 E>G No 1000Genomes
tmp_4_15125083_G_A 369 A>T No 1000Genomes
tmp_4_15125210_T_C 382 V>A No 1000Genomes
ENSVATH12329138 430 R>G No 1000Genomes
tmp_4_15125372_A_T 436 E>V No 1000Genomes
tmp_4_15125404_A_G 447 N>D No 1000Genomes
ENSVATH06806250 453 G>C No 1000Genomes
tmp_4_15125431_G_T 456 G>C No 1000Genomes
ENSVATH12329139 461 G>R No 1000Genomes
tmp_4_15125527_G_A 488 E>K No 1000Genomes
ENSVATH02946651 536 D>Y No 1000Genomes
tmp_4_15125686_T_A 541 W>R No 1000Genomes
tmp_4_15125701_C_T 546 R>C No 1000Genomes
ENSVATH02946652 547 I>N No 1000Genomes
tmp_4_15125719_G_T 552 A>S No 1000Genomes
ENSVATH00546278 595 V>I No 1000Genomes
tmp_4_15125854_A_T 597 I>L No 1000Genomes
tmp_4_15125900_A_G 612 Y>C No 1000Genomes
ENSVATH06806253 643 D>E No 1000Genomes
ENSVATH12329140 647 I>V No 1000Genomes
tmp_4_15126031_A_G 656 I>V No 1000Genomes
ENSVATH06806254 657 A>T No 1000Genomes
tmp_4_15126039_G_T 658 L>F No 1000Genomes
tmp_4_15126059_C_T 665 A>V No 1000Genomes
ENSVATH06806256 695 A>E No 1000Genomes
ENSVATH02946653 704 R>K No 1000Genomes
ENSVATH12329141 728 V>L No 1000Genomes
ENSVATH02946654 754 G>E No 1000Genomes
ENSVATH06806257 767 S>N No 1000Genomes
tmp_4_15126367_A_T 768 I>F No 1000Genomes
ENSVATH14319062 776 D>E No 1000Genomes

No associated diseases with Q9M092

3 regional properties for Q9M092

Type Name Position InterPro Accession
domain Protein kinase domain 354 - 639 IPR000719
active_site Serine/threonine-protein kinase, active site 480 - 492 IPR008271
binding_site Protein kinase, ATP binding site 360 - 382 IPR017441

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calcium ion binding Binding to a calcium ion (Ca2+).
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

2 GO annotations of biological process

Name Definition
cell surface receptor signaling pathway The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
protein phosphorylation The process of introducing a phosphate group on to a protein.

34 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P28693 EPHB2 Ephrin type-B receptor 2 Gallus gallus (Chicken) PR
P29318 EPHA3 Ephrin type-A receptor 3 Gallus gallus (Chicken) SS
Q07497 EPHB5 Ephrin type-B receptor 5 Gallus gallus (Chicken) PR
Q07496 EPHA4 Ephrin type-A receptor 4 Gallus gallus (Chicken) SS
O42422 EPHA7 Ephrin type-A receptor 7 Gallus gallus (Chicken) SS
Q07494 EPHB1 Ephrin type-B receptor 1 Gallus gallus (Chicken) SS
P54755 EPHA5 Ephrin type-A receptor 5 Gallus gallus (Chicken) SS
Q07498 EPHB3 Ephrin type-B receptor 3 Gallus gallus (Chicken) SS
P06213 INSR Insulin receptor Homo sapiens (Human) EV
P08069 IGF1R Insulin-like growth factor 1 receptor Homo sapiens (Human) EV
P14616 INSRR Insulin receptor-related protein Homo sapiens (Human) SS
P00533 EGFR Epidermal growth factor receptor Homo sapiens (Human) EV
Q15303 ERBB4 Receptor tyrosine-protein kinase erbB-4 Homo sapiens (Human) SS
P04626 ERBB2 Receptor tyrosine-protein kinase erbB-2 Homo sapiens (Human) SS
P21860 ERBB3 Receptor tyrosine-protein kinase erbB-3 Homo sapiens (Human) SS
P05532 Kit Mast/stem cell growth factor receptor Kit Mus musculus (Mouse) PR
P26618 Pdgfra Platelet-derived growth factor receptor alpha Mus musculus (Mouse) SS
P35917 Flt4 Vascular endothelial growth factor receptor 3 Mus musculus (Mouse) SS
P35918 Kdr Vascular endothelial growth factor receptor 2 Mus musculus (Mouse) PR
Q7X8C5 WAKL2 Wall-associated receptor kinase-like 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q8VYA3 WAKL10 Wall-associated receptor kinase-like 10 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C9L5 WAKL9 Wall-associated receptor kinase-like 9 Arabidopsis thaliana (Mouse-ear cress) PR
Q9S9M2 WAKL4 Wall-associated receptor kinase-like 4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LMN7 WAK5 Wall-associated receptor kinase 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LSV3 WAKL16 Putative wall-associated receptor kinase-like 16 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M342 WAKL15 Wall-associated receptor kinase-like 15 Arabidopsis thaliana (Mouse-ear cress) PR
Q0WNY5 WAKL18 Wall-associated receptor kinase-like 18 Arabidopsis thaliana (Mouse-ear cress) PR
Q8JFR5 kita Mast/stem cell growth factor receptor kita Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q9I8N6 csf1r Macrophage colony-stimulating factor 1 receptor Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q5GIT4 kdr Vascular endothelial growth factor receptor 2 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q90Z00 fgfr1a Fibroblast growth factor receptor 1-A Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q5MD89 flt4 Vascular endothelial growth factor receptor 3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q8JG38 fgfr2 Fibroblast growth factor receptor 2 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q9I8X3 fgfr3 Fibroblast growth factor receptor 3 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MSYKNTNNSH LILFKLLLLL ILYSADLTAS SSCRSECGGC KCGGIAIPYP FGIGKGCYLE
70 80 90 100 110 120
KSYEIECLNT SGKLVPFLSV ISKEVVSIHL PGRQSFGSVR VRSPITSAGC SSDGKDSAPV
130 140 150 160 170 180
MNLTDSPFFV SDINNLVGVG CSSKVSLEHI KQNMVGCELN CSTTNASDSN SIPFFDKTGC
190 200 210 220 230 240
SFSYTFAQVC TGNKPEDMGC DGRGCCQASL PREPQQVIGI RIESNDGKST TSGDCRVAFL
250 260 270 280 290 300
TDEFFSLSKL TKPEQLHAKR YATLSLGWIM QTRNTSFVNS LACKIRKDTD TAYSNDQSIK
310 320 330 340 350 360
CICDYTMSII SDIRYANCEC NLGYKGNPYD SDGCRDIDEC KENPKYCKET DTCVNFEGGY
370 380 390 400 410 420
RCVGDKTKAI MIGAGTGFGV LVLVGGVWWL RKFLVKRRMA KRKKKFFKRN GGLLLQQELN
430 440 450 460 470 480
TRQGVVEKAR IFTSKELEKA TENFSENRVL GHGGQGTVYK GMLVDGRTVA VKKSKVIDED
490 500 510 520 530 540
KLQEFINEVV ILSQINHRHV VKLLGCCLET EVPILVYEFI INGNLFKHIH EEEADDYTMI
550 560 570 580 590 600
WGMRLRIAVD IAGALSYLHS AASSPIYHRD IKSTNILLDE KYRAKVADFG TSRSVTIDQT
610 620 630 640 650 660
HWTTVISGTV GYVDPEYYRS SQYTEKSDVY SFGVILAELI TGDKPVIMVQ NTQEIIALAE
670 680 690 700 710 720
HFRVAMKERR LSDIMDARIR DDSKPEQVMA VANLAMKCLS SRGRNRPNMR EVFTELERIC
730 740 750 760 770 780
TSPEDSQVQN RIDEEEEEDG VEEEEEVVTI VHRGDSWSIG VTAPASSIVA SPPSSDVEPL
NPLLTW