Q9LYW3
Gene name |
MED7A (MED7_1, At5g03220, F15A17.250, F9G14.160) |
Protein name |
Mediator of RNA polymerase II transcription subunit 7a |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G03220 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9LYW3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9LYW3-F1 | Predicted | AlphaFoldDB |
21 variants for Q9LYW3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH03013116 | 13 | Y>F | No | 1000Genomes | |
| tmp_5_768544_C_T | 14 | R>K | No | 1000Genomes | |
| ENSVATH03013115 | 19 | Y>F | No | 1000Genomes | |
| tmp_5_768509_C_T | 26 | A>T | No | 1000Genomes | |
| ENSVATH13895849 | 41 | G>V | No | 1000Genomes | |
| ENSVATH10522189 | 43 | N>K | No | 1000Genomes | |
| tmp_5_768451_G_A | 45 | T>I | No | 1000Genomes | |
| ENSVATH13895847 | 53 | L>F | No | 1000Genomes | |
| ENSVATH06913934 | 55 | E>K | No | 1000Genomes | |
| ENSVATH13895846 | 60 | Q>L | No | 1000Genomes | |
| ENSVATH06913933 | 65 | D>V | No | 1000Genomes | |
| ENSVATH06913932 | 66 | S>Y | No | 1000Genomes | |
| ENSVATH10522164 | 69 | D>V | No | 1000Genomes | |
| ENSVATH03013103 | 72 | N>K | No | 1000Genomes | |
| ENSVATH00603379 | 126 | R>I | No | 1000Genomes | |
| ENSVATH03013098 | 154 | A>V | No | 1000Genomes | |
| ENSVATH10522158 | 159 | K>M | No | 1000Genomes | |
| ENSVATH00603377 | 163 | L>V | No | 1000Genomes | |
| ENSVATH10522157 | 166 | D>E | No | 1000Genomes | |
| ENSVATH06913923 | 167 | G>D | No | 1000Genomes | |
| ENSVATH10522156 | 167 | G>S | No | 1000Genomes |
No associated diseases with Q9LYW3
No regional properties for Q9LYW3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9LYW3 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| core mediator complex | A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. |
| mediator complex | A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| transcription coregulator activity | A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| de-etiolation | The greening response of plants grown in the dark (etiolated) as a result of chloroplast biogenesis and the accumulation of chlorophyll. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| regulation of unidimensional cell growth | Any process that modulates the frequency, rate or extent of unidimensional cell growth, the process in which a cell irreversibly increases in size in one |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MATATYPPPP | PYYRLYKDYS | ENPNSAPEPP | PPIEGTYVCF | GGNYTTEDVL | PSLEEQGVPQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LYPKDSNLDY | KNELRSLNRE | LQLHILELAD | VLVDRPSQYA | KRIGEISSIF | KNLHHLLNSL |
| 130 | 140 | 150 | 160 | ||
| RPHQARATLI | HIMELQIQQR | KQAVEDIKRR | REEAQRLLKD | AYLTLDGQ |