Q9LMT2

PR
Gene name
PAPS1
Protein name
Nuclear poly(A) polymerase 1
Names
PAP(I), Poly(A) polymerase I, Polynucleotide adenylyltransferase 1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G17980
EC number
2.7.7.19: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-67 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9LMT2

Entry ID Method Resolution Chain Position Source
AF-Q9LMT2-F1 Predicted AlphaFoldDB

25 variants for Q9LMT2

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH04594847 31 R>G No 1000Genomes
tmp_1_6191323_C_G 32 E>D No 1000Genomes
ENSVATH13917415 73 A>T No 1000Genomes
tmp_1_6190925_A_T 89 F>Y No 1000Genomes
tmp_1_6189886_G_A 180 S>F No 1000Genomes
tmp_1_6189357_C_T 293 D>N No 1000Genomes
ENSVATH04594840 403 M>T No 1000Genomes
ENSVATH04594839 438 E>G No 1000Genomes
tmp_1_6188562_G_A 502 S>L No 1000Genomes
tmp_1_6188466_A_G 534 V>A No 1000Genomes
tmp_1_6188464_C_G 535 D>H No 1000Genomes
ENSVATH01066158 536 G>R No 1000Genomes
tmp_1_6188392_C_T 559 V>I No 1000Genomes
tmp_1_6188374_T_C 565 N>D No 1000Genomes
tmp_1_6188326_T_A 581 S>C No 1000Genomes
ENSVATH04594838 582 P>H No 1000Genomes
tmp_1_6188209_C_T 620 A>T No 1000Genomes
ENSVATH01066157 634 F>Y No 1000Genomes
ENSVATH04594837 642 E>Q No 1000Genomes
tmp_1_6188127_T_C 647 K>R No 1000Genomes
tmp_1_6188121_G_A 649 A>V No 1000Genomes
ENSVATH01066156 661 E>K No 1000Genomes
ENSVATH00030178 696 R>Q No 1000Genomes
ENSVATH11439344 711 N>I No 1000Genomes
ENSVATH11439343 711 N>K No 1000Genomes

No associated diseases with Q9LMT2

4 regional properties for Q9LMT2

Type Name Position InterPro Accession
domain Polymerase, nucleotidyl transferase domain 82 - 145 IPR002934
domain Poly(A) polymerase, RNA-binding domain 359 - 417 IPR007010-1
domain Poly(A) polymerase, RNA-binding domain 420 - 488 IPR007010-2
domain Poly(A) polymerase, central domain 12 - 356 IPR007012

Functions

Description
EC Number 2.7.7.19 Nucleotidyltransferases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
polynucleotide adenylyltransferase activity Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group.
RNA binding Binding to an RNA molecule or a portion thereof.

7 GO annotations of biological process

Name Definition
flower development The process whose specific outcome is the progression of the flower over time, from its formation to the mature structure. The flower is the reproductive structure in a plant, and its development begins with the transition of the vegetative or inflorescence meristem into a floral meristem.
leaf development The process whose specific outcome is the progression of the leaf over time, from its formation to the mature structure.
mRNA polyadenylation The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript.
negative regulation of cell population proliferation Any process that stops, prevents or reduces the rate or extent of cell proliferation.
negative regulation of innate immune response Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response.
petal formation The process that gives rise to the petal. This process pertains to the initial formation of a structure from unspecified parts.
RNA polyadenylation The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P29468 PAP1 Poly(A) polymerase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
10 20 30 40 50 60
MASVQQNGQR FGVSEPISMG GPTEFDVIKT RELEKHLQDV GLYESKEEAV RREEVLGILD
70 80 90 100 110 120
QIVKTWIKTI SRAKGLNDQL LHEANAKIFT FGSYRLGVHG PGADIDTLCV GPRHATREGD
130 140 150 160 170 180
FFGELQRMLS EMPEVTELHP VPDAHVPLMG FKLNGVSIDL LYAQLPLWVI PEDLDLSQDS
190 200 210 220 230 240
ILQNADEQTV RSLNGCRVTD QILRLVPNIQ NFRTTLRCMR FWAKRRGVYS NVSGFLGGIN
250 260 270 280 290 300
WALLVARICQ LYPNALPNIL VSRFFRVFYQ WNWPNAIFLC SPDEGSLGLQ VWDPRINPKD
310 320 330 340 350 360
RLHIMPIITP AYPCMNSSYN VSESTLRIMK GEFQRGNEIC EAMESNKADW DTLFEPFAFF
370 380 390 400 410 420
EAYKNYLQID ISAANVDDLR KWKGWVESRL RQLTLKIERH FKMLHCHPHP HDFQDTSRPL
430 440 450 460 470 480
HCSYFMGLQR KQGVPAAEGE QFDIRRTVEE FKHTVNAYTL WIPGMEISVG HIKRRSLPNF
490 500 510 520 530 540
VFPGGVRPSH TSKGTWDSNR RSEHRNSSTS SAPAATTTTT EMSSESKAGS NSPVDGKKRK
550 560 570 580 590 600
WGDSETLTDQ PRNSKHIAVS VPVENCEGGS PNPSVGSICS SPMKDYCTNG KSEPISKDPP
610 620 630 640 650 660
ENVVAFSKDP PESLPIEKIA TPQAHETEEL EESFDFGNQV IEQISHKVAV LSATATIPPF
670 680 690 700 710
EATSNGSPFP YEAVEELEVL PTRQPDAAHR PSVQQRKPII KLSFTSLGKT NGK