AiPD: Autoinhibited Protein Database

Gene name	G6PD5
Protein name	Glucose-6-phosphate 1-dehydrogenase 5, cytoplasmic
Names	AtG6PD5, G6PDH5
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT3G27300
EC number	1.1.1.49: With NAD(+) or NADP(+) as acceptor
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-49 (Predicted disordered autoinhibitory region) PR

1-49 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9LK23-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH05934729	2	G>C	No	1000Genomes
ENSVATH05934728	14	L>S	No	1000Genomes
ENSVATH02218206	17	D>G	No	1000Genomes
ENSVATH02218205	21	K>Q	No	1000Genomes
tmp_3_10086205_T_A	28	E>D	No	1000Genomes
tmp_3_10086117_G_A	58	Q>*	No	1000Genomes
ENSVATH11053309	84	K>Q	No	1000Genomes
ENSVATH11053308	86	R>C	No	1000Genomes
ENSVATH02218203	99	T>P	No	1000Genomes
tmp_3_10085683_C_G	119	E>D	No	1000Genomes
ENSVATH05934723	127	K>M	No	1000Genomes
ENSVATH00354975	130	L>S	No	1000Genomes
ENSVATH02218199	139	A>S	No	1000Genomes
ENSVATH02218198	140	E>K	No	1000Genomes
ENSVATH02218198	140	E>Q	No	1000Genomes
ENSVATH05934722	165	A>E	No	1000Genomes
tmp_3_10085183_G_A	231	R>C	No	1000Genomes
tmp_3_10085146_G_C	243	A>G	No	1000Genomes
tmp_3_10084648_C_T	297	R>Q	No	1000Genomes
tmp_3_10084479_C_T	312	D>N	No	1000Genomes
ENSVATH02218181	313	E>K	No	1000Genomes
tmp_3_10084411_G_C	334	N>K	No	1000Genomes
ENSVATH05934710	335	T>S	No	1000Genomes
tmp_3_10083994_G_C	406	L>V	No	1000Genomes
ENSVATH05934702	465	E>K	No	1000Genomes
ENSVATH11053232	471	L>R	No	1000Genomes
tmp_3_10083415_T_A	485	K>I	No	1000Genomes

Type	Name	Position	InterPro Accession
active_site	Glucose-6-phosphate dehydrogenase, active site	212 - 218	IPR019796
domain	Glucose-6-phosphate dehydrogenase, NAD-binding	35 - 222	IPR022674
domain	Glucose-6-phosphate dehydrogenase, C-terminal	224 - 503	IPR022675

		Description
EC Number	1.1.1.49	With NAD(+) or NADP(+) as acceptor
Subcellular Localization	Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
chloroplast	A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Name	Definition
glucose-6-phosphate dehydrogenase activity	Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+.
NADP binding	Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.

Name	Definition
glucose metabolic process	The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
pentose-phosphate shunt, oxidative branch	The branch of the pentose-phosphate shunt which involves the oxidation of glucose 6-P and produces ribulose 5-P, reduced NADP+ and carbon dioxide (CO2).

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P11412	ZWF1	Glucose-6-phosphate 1-dehydrogenase	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR