Q9LJL3

PR
Gene name
PREP1 (ZNMP1, At3g19170, MVI11.6, MVI11.7, MVI11_8)
Protein name
Presequence protease 1, chloroplastic/mitochondrial
Names
AtPreP1, PreP 1, Zinc metalloprotease 1, AtZnMP1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G19170
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

7-82 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q9LJL3

Entry ID Method Resolution Chain Position Source
2FGE X-ray 210 A A/B 86-1080 PDB
AF-Q9LJL3-F1 Predicted AlphaFoldDB

68 variants for Q9LJL3

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH00333593 25 P>S No 1000Genomes
ENSVATH10777269 26 R>H No 1000Genomes
tmp_3_6631744_T_A 44 N>I No 1000Genomes
ENSVATH00333592 58 L>F No 1000Genomes
ENSVATH05861522 59 L>F No 1000Genomes
ENSVATH10777268 60 L>F No 1000Genomes
ENSVATH00333591 61 R>Q No 1000Genomes
ENSVATH13945931 65 R>T No 1000Genomes
tmp_3_6631669_G_A 69 A>V No 1000Genomes
tmp_3_6631661_G_A 72 R>C No 1000Genomes
tmp_3_6631657_C_T 73 S>N No 1000Genomes
tmp_3_6631640_A_T 79 S>T No 1000Genomes
ENSVATH05861520 80 R>H No 1000Genomes
ENSVATH05861519 85 A>S No 1000Genomes
tmp_3_6631231_T_A 126 K>N No 1000Genomes
tmp_3_6631211_T_A 133 E>V No 1000Genomes
ENSVATH13945929 260 F>C No 1000Genomes
tmp_3_6629902_C_T 285 E>K No 1000Genomes
ENSVATH05861505 306 E>K No 1000Genomes
tmp_3_6629725_G_A 312 R>C No 1000Genomes
tmp_3_6629706_C_T 318 S>N No 1000Genomes
ENSVATH13945925 343 M>L No 1000Genomes
tmp_3_6629508_C_G 347 S>T No 1000Genomes
tmp_3_6629500_G_T 350 P>T No 1000Genomes
tmp_3_6629375_C_A 391 L>F No 1000Genomes
tmp_3_6629323_G_A 409 H>Y No 1000Genomes
tmp_3_6629315_C_T 411 M>I No 1000Genomes
ENSVATH05861497 447 G>S No 1000Genomes
tmp_3_6629185_C_T 455 E>K No 1000Genomes
tmp_3_6629125_C_T 475 E>K No 1000Genomes
ENSVATH02164332 528 T>A No 1000Genomes
tmp_3_6628888_G_A 528 T>M No 1000Genomes
ENSVATH00333578 533 A>T No 1000Genomes
tmp_3_6628837_G_A 545 A>V No 1000Genomes
tmp_3_6628830_A_C 547 F>L No 1000Genomes
ENSVATH00333577 563 T>I No 1000Genomes
ENSVATH05861493 571 E>K No 1000Genomes
ENSVATH05861492 594 E>K No 1000Genomes
tmp_3_6628600_G_A 601 R>C No 1000Genomes
ENSVATH05861491 628 G>V No 1000Genomes
tmp_3_6628504_C_T 633 E>K No 1000Genomes
tmp_3_6628500_G_C 634 P>R No 1000Genomes
ENSVATH10777201 647 V>A No 1000Genomes
tmp_3_6628320_G_A 670 S>L No 1000Genomes
tmp_3_6628312_G_A 673 H>Y No 1000Genomes
ENSVATH10777200 682 F>C No 1000Genomes
tmp_3_6628018_T_C 692 K>R No 1000Genomes
ENSVATH00333570 844 I>V No 1000Genomes
tmp_3_6626625_C_T 849 A>T No 1000Genomes
ENSVATH02164322 859 K>N No 1000Genomes
tmp_3_6626585_G_A 862 A>V No 1000Genomes
ENSVATH05861476 866 D>A No 1000Genomes
tmp_3_6626562_C_T 870 E>K No 1000Genomes
tmp_3_6626313_A_T 923 I>N No 1000Genomes
tmp_3_6626277_C_A 935 S>I No 1000Genomes
ENSVATH10777143 974 D>N No 1000Genomes
tmp_3_6625973_T_A 1008 Y>F No 1000Genomes
ENSVATH05861470 1014 H>Y No 1000Genomes
tmp_3_6625849_G_C 1019 T>S No 1000Genomes
ENSVATH10777137 1021 E>D No 1000Genomes
tmp_3_6625830_T_G 1025 R>S No 1000Genomes
ENSVATH10777123 1036 K>N No 1000Genomes
ENSVATH10777122 1047 V>A No 1000Genomes
tmp_3_6625678_A_G 1048 V>A No 1000Genomes
ENSVATH05861467 1054 A>T No 1000Genomes
ENSVATH13945902 1054 A>V No 1000Genomes
tmp_3_6625649_C_T 1058 A>T No 1000Genomes
ENSVATH10777121 1060 A>V No 1000Genomes

No associated diseases with Q9LJL3

3 regional properties for Q9LJL3

Type Name Position InterPro Accession
domain Peptidase M16, C-terminal 301 - 488 IPR007863
domain Peptidase M16, N-terminal 154 - 240 IPR011765
domain Peptidase M16C associated 566 - 815 IPR013578

Functions

Description
EC Number
Subcellular Localization
  • Plastid, chloroplast stroma
  • Mitochondrion matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it.
chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
chloroplast envelope The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
chloroplast stroma The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
metalloendopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

1 GO annotations of biological process

Name Definition
protein processing Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5JRX3 PITRM1 Presequence protease, mitochondrial Homo sapiens (Human) PR
10 20 30 40 50 60
MLRTVSCLAS RSSSSLFFRF FRQFPRSYMS LTSSTAALRV PSRNLRRISS PSVAGRRLLL
70 80 90 100 110 120
RRGLRIPSAA VRSVNGQFSR LSVRAVATQP APLYPDVGQD EAEKLGFEKV SEEFISECKS
130 140 150 160 170 180
KAILFKHKKT GCEVMSVSNE DENKVFGVVF RTPPKDSTGI PHILEHSVLC GSRKYPVKEP
190 200 210 220 230 240
FVELLKGSLH TFLNAFTYPD RTCYPVASTN TKDFYNLVDV YLDAVFFPKC VDDAHTFQQE
250 260 270 280 290 300
GWHYELNDPS EDISYKGVVF NEMKGVYSQP DNILGRIAQQ ALSPENTYGV DSGGDPKDIP
310 320 330 340 350 360
NLTFEEFKEF HRQYYHPSNA RIWFYGDDDP VHRLRVLSEY LDMFEASPSP NSSKIKFQKL
370 380 390 400 410 420
FSEPVRLVEK YPAGRDGDLK KKHMLCVNWL LSEKPLDLQT QLALGFLDHL MLGTPASPLR
430 440 450 460 470 480
KILLESGLGE ALVSSGLSDE LLQPQFGIGL KGVSEENVQK VEELIMDTLK KLAEEGFDND
490 500 510 520 530 540
AVEASMNTIE FSLRENNTGS FPRGLSLMLQ SISKWIYDMD PFEPLKYTEP LKALKTRIAE
550 560 570 580 590 600
EGSKAVFSPL IEKLILNNSH RVTIEMQPDP EKATQEEVEE KNILEKVKAA MTEEDLAELA
610 620 630 640 650 660
RATEELKLKQ ETPDPPEALR CVPSLNLGDI PKEPTYVPTE VGDINGVKVL RHDLFTNDII
670 680 690 700 710 720
YTEVVFDIGS LKHELLPLVP LFCQSLLEMG TKDLTFVQLN QLIGRKTGGI SVYPLTSSVR
730 740 750 760 770 780
GKDEPCSKII VRGKSMAGRA DDLFNLMNCL LQEVQFTDQQ RFKQFVSQSR ARMENRLRGS
790 800 810 820 830 840
GHGIAAARMD AMLNIAGWMS EQMGGLSYLE FLHTLEKKVD EDWEGISSSL EEIRRSLLAR
850 860 870 880 890 900
NGCIVNMTAD GKSLTNVEKS VAKFLDLLPE NPSGGLVTWD GRLPLRNEAI VIPTQVNYVG
910 920 930 940 950 960
KAGNIYSTGY ELDGSAYVIS KHISNTWLWD RVRVSGGAYG GFCDFDSHSG VFSYLSYRDP
970 980 990 1000 1010 1020
NLLKTLDIYD GTGDFLRGLD VDQETLTKAI IGTIGDVDSY QLPDAKGYSS LLRHLLGVTD
1030 1040 1050 1060 1070
EERQRKREEI LTTSLKDFKD FAQAIDVVRD KGVAVAVASA EDIDAANNER SNFFEVKKAL