Q9LEU8
Gene name |
At5g10920 (T30N20.190) |
Protein name |
Argininosuccinate lyase, chloroplastic |
Names |
Arginosuccinase |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G10920 |
EC number |
4.3.2.1: Lyases acting on amides, amidines, etc |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9LEU8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9LEU8-F1 | Predicted | AlphaFoldDB |
19 variants for Q9LEU8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00615910 | 3 | A>P | No | 1000Genomes | |
| ENSVATH00615911 | 26 | H>Q | No | 1000Genomes | |
| ENSVATH00615912 | 28 | S>Y | No | 1000Genomes | |
| tmp_5_3441892_T_A | 30 | S>T | No | 1000Genomes | |
| ENSVATH06950381 | 34 | P>L | No | 1000Genomes | |
| ENSVATH10689779 | 35 | G>R | No | 1000Genomes | |
| ENSVATH06950383 | 38 | S>A | No | 1000Genomes | |
| ENSVATH03045070 | 42 | P>A | No | 1000Genomes | |
| ENSVATH00615913 | 52 | D>N | No | 1000Genomes | |
| tmp_5_3441964_G_A | 54 | A>T | No | 1000Genomes | |
| ENSVATH00615914 | 72 | K>N | No | 1000Genomes | |
| tmp_5_3442298_A_G | 125 | Q>R | No | 1000Genomes | |
| tmp_5_3442534_G_A | 204 | A>T | No | 1000Genomes | |
| tmp_5_3443188_G_C | 312 | W>C | No | 1000Genomes | |
| ENSVATH00615916 | 393 | G>R | No | 1000Genomes | |
| ENSVATH13987844 | 464 | E>Q | No | 1000Genomes | |
| tmp_5_3443741_A_T | 468 | K>M | No | 1000Genomes | |
| tmp_5_3443759_A_G | 474 | E>G | No | 1000Genomes | |
| ENSVATH00615917 | 516 | S>T | No | 1000Genomes |
No associated diseases with Q9LEU8
17 regional properties for Q9LEU8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | NGN domain | 183 - 265 | IPR005100 |
| domain | KOW | 273 - 300 | IPR005824-1 |
| domain | KOW | 425 - 452 | IPR005824-2 |
| domain | KOW | 477 - 522 | IPR005824-3 |
| domain | KOW | 601 - 628 | IPR005824-4 |
| domain | KOW | 712 - 739 | IPR005824-5 |
| domain | KOW | 988 - 1015 | IPR005824-6 |
| conserved_site | Ribosomal protein L24/L26, conserved site | 429 - 446 | IPR005825 |
| domain | NusG-like, N-terminal | 181 - 268 | IPR006645 |
| domain | Spt5 transcription elongation factor, N-terminal | 90 - 177 | IPR022581 |
| domain | NGN domain, eukaryotic | 183 - 266 | IPR039385 |
| domain | Spt5, KOW domain repeat 1 | 277 - 314 | IPR041973 |
| domain | Spt5, KOW domain repeat 2 | 426 - 476 | IPR041975 |
| domain | Spt5, KOW domain repeat 3 | 477 - 527 | IPR041976 |
| domain | Spt5, KOW domain repeat 4 | 605 - 647 | IPR041977 |
| domain | Spt5, KOW domain repeat 5 | 711 - 758 | IPR041978 |
| domain | Spt5, KOW domain repeat 6 | 982 - 1039 | IPR041980 |
Functions
| Description | ||
|---|---|---|
| EC Number | 4.3.2.1 | Lyases acting on amides, amidines, etc |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast | A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. |
| chloroplast stroma | The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| argininosuccinate lyase activity | Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| arginine biosynthetic process via ornithine | The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGAIDLSFSQ | SLLFSSSRSN | LSSSTHRSVS | FLPPGSKSRC | LPPLRSMSHD | DDTASKEVKL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WGGRFEESVT | EKVEKFTESI | SFDKVLYKQD | IMGSKAHASM | LAHQGLITDS | DKDSILRGLD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DIERQIEANK | FEWRTDREDV | HMNIEAALTD | LIGEPAKKLH | TARSRNDQVA | TDFRLWCRDA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IDTIIVKIRN | LQRALVELAL | KNEALIVPGY | THLQRAQPVL | LPHVLLTFVE | QLERDAGRYV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DCRARLNFSP | LGACALAGTG | LPIDRFMTAN | ALGFTEPMRN | SIDAVSDRDF | VLEFLYTNAN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TGIHLSRLGE | EWVLWASEEF | GFMTPSDSVS | TGSSIMPQKK | NPDPMELVRG | KSARVIGDLV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TVLTLCKGLP | LAYNRDFQED | KEPMFDSTKT | IMGMIDVSAE | FAQNVTFNED | RIKKSLPAGH |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LDATTLADYL | VKKGMPFRSS | HDIVGKLVGV | CVSKGCELQN | LSLEEMKKLS | PVFEEDVFGF |
| 490 | 500 | 510 | |||
| LGVENSVNKF | SSYGSTGSNC | VAEQLGYWVN | KLNITST |