Q9L6S1

PR
Gene name
rep
Protein name
ATP-dependent DNA helicase Rep
Names
Species
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
KEGG Pathway
stm:STM3912
EC number
5.6.2.4: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

613-674 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9L6S1

Entry ID Method Resolution Chain Position Source
AF-Q9L6S1-F1 Predicted AlphaFoldDB

No variants for Q9L6S1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9L6S1

No associated diseases with Q9L6S1

2 regional properties for Q9L6S1

Type Name Position InterPro Accession
domain UvrD-like helicase, ATP-binding domain 1 - 280 IPR014016
domain UvrD-like DNA helicase, C-terminal 271 - 613 IPR014017

Functions

Description
EC Number 5.6.2.4 Enzymes altering nucleic acid conformation
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

5 GO annotations of molecular function

Name Definition
3'-5' DNA helicase activity Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis.
3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
single-stranded DNA binding Binding to single-stranded DNA.

2 GO annotations of biological process

Name Definition
DNA unwinding involved in DNA replication The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.
recombinational repair A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRLNPGQQHA VEFVTGPCLV LAGAGSGKTR VITNKIAHLI RGCGYQARHI AAVTFTNKAA
70 80 90 100 110 120
REMKERVGQT LGRKEARGLM ISTFHTLGLD IIKREYAALG MKSNFSLFDD TDQVALLKEL
130 140 150 160 170 180
TEGLIEDDKV LLQQLISTIS NWKNDLKTPA QAAAGAKGER DRIFAHCYGL YDAHMKACNV
190 200 210 220 230 240
LDFDDLILLP TLLLQRNDEV RERWQNKIRY LLVDEYQDTN TSQYELVKLL VGQRARFTVV
250 260 270 280 290 300
GDDDQSIYSW RGARPQNLVL LSQDFPALQV IKLEQNYRSS GRILKAANIL IANNPHVFEK
310 320 330 340 350 360
RLFSELGYGA ELKVLSANNE EHEAERVTGE LIAHHFVNKT QYKDYAILYR GNHQSRVFEK
370 380 390 400 410 420
FLMQNRIPYK ISGGTSFFSR PEIKDLLAYL RVLTNPDDDS AFLRIVNTPK REIGPATLQK
430 440 450 460 470 480
LGEWAMTRNK SLFTASFDMG LSQKLTGRGY DSLTRFTHWL GEIQRLAERE PVAAVRDLIH
490 500 510 520 530 540
GIDYESWLYE TSPSPKAAEM RMKNVNQLFS WMTEMLEGNE LDEPMTLTQV VTRFTLRDMM
550 560 570 580 590 600
ERGESEEELD QVQLMTLHAS KGLEFPYVYM VGMEEGFLPH QSSIDEDNIE EERRLAYVGI
610 620 630 640 650 660
TRAQKELTFT LCKERRQYGE LVRPEPSRFL LELPQDDLIW EQERKVVSAE ERMQKGQSHL
670
ANLKAMMAAK RAKS