Q9KWU6

PR
Gene name
rpoC
Protein name
DNA-directed RNA polymerase subunit beta'
Names
RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'
Species
Thermus aquaticus
KEGG Pathway
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1466-1524 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

15 structures for Q9KWU6

Entry ID Method Resolution Chain Position Source
1HQM X-ray 330 A D 1-1524 PDB
1I6V X-ray 330 A D 1-1524 PDB
1L9U X-ray 400 A D/M 1-1524 PDB
1L9Z X-ray 650 A D 1-1524 PDB
1YNJ X-ray 320 A D/J 1-1524 PDB
1YNN X-ray 330 A D/J 1-1524 PDB
2AUJ X-ray 270 A D 151-455 PDB
2GHO X-ray 500 A PDB
4XLN X-ray 400 A D/J 1-1524 PDB
4XLP X-ray 400 A D/J 1-1524 PDB
4XLQ X-ray 460 A D/J 1-1524 PDB
4XLR X-ray 430 A D/J 1-1524 PDB
4XLS X-ray 401 A D/J 1-1524 PDB
5TJG X-ray 260 A D 1-1524 PDB
AF-Q9KWU6-F1 Predicted AlphaFoldDB

No variants for Q9KWU6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9KWU6

No associated diseases with Q9KWU6

8 regional properties for Q9KWU6

Type Name Position InterPro Accession
domain RNA polymerase, alpha subunit 620 - 761 IPR000722
domain RNA polymerase, N-terminal 510 - 793 IPR006592
domain RNA polymerase Rpb1, domain 3 768 - 953 IPR007066
domain RNA polymerase Rpb1, domain 1 2 - 159 IPR007080-1
domain RNA polymerase Rpb1, domain 1 456 - 618 IPR007080-2
domain RNA polymerase Rpb1, domain 5 1064 - 1268 IPR007081-1
domain RNA polymerase Rpb1, domain 5 1305 - 1429 IPR007081-2
domain RNA polymerase Rpb1, domain 4 984 - 1050 IPR007083

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

4 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
magnesium ion binding Binding to a magnesium (Mg) ion.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKKEVRKVRI ALASPEKIRS WSYGEVEKPE TINYRTLKPE RDGLFDERIF GPIKDYECAC
70 80 90 100 110 120
GKYKRQRFEG KVCERCGVEV TRSIVRRYRM GHIELATPAA HIWFVKDVPS KIGTLLDLSA
130 140 150 160 170 180
TELEQVLYFN KYIVLDPKGA VLDGVPVEKR QLLTDEEYRE LRYGKQETYP LPAGVDALVK
190 200 210 220 230 240
DGEEVVKGQE LAPGVVSRMD GVALYRFPRR VRVDYLRKER AALRIPLSAW VEKEAYRPGE
250 260 270 280 290 300
VLAELSEPYL FRAEESGVVE LKDLAEGHLI YLRQEEEVVA RYFLPAGMTP LVVEGEIVEV
310 320 330 340 350 360
GQPLAEGKGL LRLPRHMTAK EVEAEEEGDS VHLTLFLEWT EPKDYKVAPH MNVIVPEGAK
370 380 390 400 410 420
VQAGEKIVAA IDPEEEVIAE AEGVVHLHEP ASILVVKARV YPFEDDVEVT TGDRVAPGDV
430 440 450 460 470 480
LADGGKVKSE IYGRVEVDLV RNVVRVVESY DIDARMGAEA IQELLKELDL EKLERELLEE
490 500 510 520 530 540
MKHPSRARRA KARKRLEVVR AFLDSGNRPE WMILEAVPVL PPDLRPMVQV DGGRFATSDL
550 560 570 580 590 600
NDLYRRLINR NNRLKKLLAQ GAPEIIIRNE KRMLQEAVDA VIDNGRRGSP VTNPGSERPL
610 620 630 640 650 660
RSLTDILSGK QGRFRQNLLG KRVDYSGRSV IVVGPQLKLH QCGLPKRMAL ELFKPFLLKK
670 680 690 700 710 720
MEEKAFAPNV KAARRMLERQ RDIKDEVWDA LEEVIHGKVV LLNRAPTLHR LGIQAFQPVL
730 740 750 760 770 780
VEGQSIQLHP LVCEAFNADF DGDQMAVHVP LSSFAQAEAR IQMLSAHNLL SPASGEPLAK
790 800 810 820 830 840
PSRDIILGLY YITQVRKEKK GAGMAFATPE EALAAYERGE VALNAPIVVA GRETSVGRLK
850 860 870 880 890 900
FVFANPDEAL LAVAHGLLDL QDVVTVRYLG RRLETSPGRI LFARIVGEAV GDEKVAQELI
910 920 930 940 950 960
QMDVPQEKNS LKDLVYQAFL RLGMEKTARL LDALKYYGFT LSTTSGITIG IDDAVIPEEK
970 980 990 1000 1010 1020
QRYLEEADRK LRQIEQAYEM GFLTDRERYD QVIQLWTETT EKVTQAVFKN FEENYPFNPL
1030 1040 1050 1060 1070 1080
YVMAQSGARG NPQQIRQLCG MRGLMQKPSG ETFEVPVRSS FREGLTVLEY FISSHGARKG
1090 1100 1110 1120 1130 1140
GADTALRTAD SGYLTRKLVD VAHEIVVREA DCGTTNYISV PLFQMDEVTR TLRLRKRSDI
1150 1160 1170 1180 1190 1200
ESGLYGRVLA REVEALGRRL EEGRYLSLED VHFLIKAAEA GEVREVPVRS PLTCQTRYGV
1210 1220 1230 1240 1250 1260
CQKCYGYDLS MARPVSIGEA VGVVAAESIG EPGTQLTMRT FHTGGVAVGT DITQGLPRVI
1270 1280 1290 1300 1310 1320
ELFEARRPKA KAVISEIDGV VRIEEGEDRL SVFVESEGFS KEYKLPKDAR LLVKDGDYVE
1330 1340 1350 1360 1370 1380
AGQPLTRGAI DPHQLLEAKG PEAVERYLVD EIQKVYRAQG VKLHDKHIEI VVRQMLKYVE
1390 1400 1410 1420 1430 1440
VTDPGDSRLL EGQVLEKWDV EALNERLIAE GKVPVAWKPL LMGVTKSALS TKSWLSAASF
1450 1460 1470 1480 1490 1500
QNTTHVLTEA AIAGKKDELI GLKENVILGR LIPAGTGSDF VRFTQVVDQR TLKAIEEARK
1510 1520
EAVEAKEKEA PRRPVRREQP GKGL