Q9KSE5

PR
Gene name
bsrV
Protein name
Broad specificity amino-acid racemase
Names
Broad spectrum racemase
Species
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
KEGG Pathway
vch:VC_1312
EC number
5.1.1.10: Acting on amino acids and derivatives
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-50 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for Q9KSE5

Entry ID Method Resolution Chain Position Source
4BEQ X-ray 150 A A 24-407 PDB
4BEU X-ray 115 A A 24-407 PDB
7AGZ X-ray 152 A A/B 24-407 PDB
AF-Q9KSE5-F1 Predicted AlphaFoldDB

No variants for Q9KSE5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9KSE5

No associated diseases with Q9KSE5

3 regional properties for Q9KSE5

Type Name Position InterPro Accession
domain Alanine racemase, N-terminal 47 - 270 IPR001608
domain Alanine racemase, C-terminal 278 - 406 IPR011079
binding_site Alanine racemase, pyridoxal-phosphate attachment site 71 - 81 IPR020622

Functions

Description
EC Number 5.1.1.10 Acting on amino acids and derivatives
Subcellular Localization
  • Periplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
periplasmic space The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

7 GO annotations of molecular function

Name Definition
alanine racemase activity Catalysis of the reaction: L-alanine = D-alanine.
arginine racemase activity Catalysis of the reaction: L-arginine = D-arginine.
lysine racemase activity Catalysis of the reaction: L-lysine = D-lysine.
methionine racemase activity Catalysis of the reaction: L-methionine = D-methionine.
ornithine racemase activity Catalysis of the reaction: L-ornithine = D-ornithine.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
serine racemase activity Catalysis of the synthesis of free D-serine from L-serine.

1 GO annotations of biological process

Name Definition
D-alanine biosynthetic process The chemical reactions and pathways resulting in the formation of D-alanine, the D-enantiomer of the amino acid alanine, i.e (2R)-2-aminopropanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MHFKATLLSL SIAATLPSFS LSAAPLHIDT ALPDAAQIQQ SNSWLEISLG QFQSNIEQFK
70 80 90 100 110 120
SHMNANTKIC AIMKADAYGN GIRGLMPTII AQGIPCVGVA SNAEARAVRE SGFKGELIRV
130 140 150 160 170 180
RSASLSEMSS ALDLNIEELI GTHQQALDLA ELAKQSGKTL KVHIALNDGG MGRNGIDMTT
190 200 210 220 230 240
EAGKKEAVSI ATQPSLSVVG IMTHFPNYNA DEVRAKLAQF KESSTWLMQQ ANLKREEITL
250 260 270 280 290 300
HVANSYTALN VPEAQLDMVR PGGVLFGDLP TNPEYPSIVS FKTRVSSLHH LPKDSTVGYD
310 320 330 340 350 360
STFTTSRDSV LANLPVGYSD GYPRKMGNKA EVLINGQRAK VVGVTSMNTT VVDVTEIKGV
370 380 390 400
LPGQEVVLFG QQQKQSIAVS EMENNAELIF PELYTLWGTS NPRFYVK