Q9KSC2

PR
Gene name
prpB
Protein name
2-methylisocitrate lyase
Names
2-MIC, MICL, (2R,3S)-2-methylisocitrate lyase
Species
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
KEGG Pathway
vch:VC_1336
EC number
4.1.3.30: Oxo-acid-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-45 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9KSC2

Entry ID Method Resolution Chain Position Source
AF-Q9KSC2-F1 Predicted AlphaFoldDB

No variants for Q9KSC2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9KSC2

No associated diseases with Q9KSC2

2 regional properties for Q9KSC2

Type Name Position InterPro Accession
conserved_site Isocitrate lyase/phosphorylmutase, conserved site 129 - 134 IPR018523
domain ICL/PEPM domain 28 - 267 IPR039556

Functions

Description
EC Number 4.1.3.30 Oxo-acid-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
magnesium ion binding Binding to a magnesium (Mg) ion.
methylisocitrate lyase activity Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate.

1 GO annotations of biological process

Name Definition
propionate catabolic process, 2-methylcitrate cycle The chemical reactions and pathways resulting in the breakdown of propionate that occurs in the 2-methylcitrate cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPNNKVKENP MSLSPGAKFR LAVKTHHPLQ IVGTINPYCA MMAKSIGHQA IYLSGGGIAN
70 80 90 100 110 120
ASYGLPDLGI TTLNDVLVDV ERITNACDLP LLVDIDTGFG GAFNIARTIK AMEKAGAAAV
130 140 150 160 170 180
HMEDQVAQKR CGHRPNKAIV SQQEMVDRVK AAVDARINPE FVIMARTDAL AVEGMDSAIE
190 200 210 220 230 240
RAIACVEAGA DMIFPEAMTE LKQYEQFSTA LRSATGKPVP ILANITEFGQ TPLYSGEQLA
250 260 270 280 290 300
AVNVDMVLYP LSAFRAMNKA AENVYRHLLE HGNQEALLDQ MQTRKELYAY LHYHEYEDKL
DQLFSQPS