Q9KNW0

PR
Gene name
rimO
Protein name
Ribosomal protein S12 methylthiotransferase RimO
Names
S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO
Species
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
KEGG Pathway
vch:VC_2620
EC number
2.8.4.4: Transferring alkylthio groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-65 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9KNW0

Entry ID Method Resolution Chain Position Source
AF-Q9KNW0-F1 Predicted AlphaFoldDB

No variants for Q9KNW0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9KNW0

No associated diseases with Q9KNW0

6 regional properties for Q9KNW0

Type Name Position InterPro Accession
domain TRAM domain 401 - 467 IPR002792
domain Elp3/MiaA/NifB-like, radical SAM core domain 165 - 390 IPR006638
domain Radical SAM 30 - 467 IPR007197
domain Methylthiotransferase, N-terminal 33 - 143 IPR013848
conserved_site Methylthiotransferase, conserved site 169 - 189 IPR020612
domain RimO, TRAM domain 404 - 465 IPR041582

Functions

Description
EC Number 2.8.4.4 Transferring alkylthio groups
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

4 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
aspartic acid methylthiotransferase activity Catalysis of the methylthiolation (-SCH3 addition) of the beta-carbon of peptidyl-aspartic acid to form peptidyl-L-beta-methylthioaspartic acid.
metal ion binding Binding to a metal ion.
protein methylthiotransferase activity Catalysis of the reaction: 2 S-adenosyl-L-methionine + a

1 GO annotations of biological process

Name Definition
tRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTVQTFTPNQ TTTLETAKKT IAEQSQNSQT TGNKIGFVSL GCPKNLVDSE RILTQLRTEG
70 80 90 100 110 120
YEIVNSYHDS DVVIVNTCGF IDSAVQESLD TIGEALKENG KVIVTGCLGA REDEIRQVHP
130 140 150 160 170 180
NVLGITGPHA YQNVLEHVHQ YAPKPAHNPF TSLVPDHGVK LTPKHYAYLK ISEGCNHRCT
190 200 210 220 230 240
FCIIPSMRGD LVSRPVGEII GEAERLKNAG VKELLVISQD TSAYGVDTKH SLGFANGSPV
250 260 270 280 290 300
RHNIKALSEE LGKMGIWVRL HYVYPYPHVD EIIPLMAEGK VLPYLDIPFQ HASPRVLKMM
310 320 330 340 350 360
KRPGQAERTL ERIKKWREIC PELVIRSTFI VGFPGETEED FQILLDWLKE AQLDRVGCFK
370 380 390 400 410 420
YSPVEGAAAN EIEDQIPEDV KQDRFERFML VQQEISAAKL QKRIGSTMQV LIDEVDEEGA
430 440 450 460
IGRTYADAPE IDGLVYLNGE TNLKPGELVN VVIEHADEYD LWGSILHDAQ