Q9KNM2

PR
Gene name
spoT (VC_2710)
Protein name
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase
Names
Penta-phosphate guanosine-3'-pyrophosphohydrolase, (ppGpp)ase
Species
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
KEGG Pathway
vch:VC_2710
EC number
3.1.7.2: Diphosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

72-146 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9KNM2

Entry ID Method Resolution Chain Position Source
AF-Q9KNM2-F1 Predicted AlphaFoldDB

No variants for Q9KNM2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9KNM2

No associated diseases with Q9KNM2

7 regional properties for Q9KNM2

Type Name Position InterPro Accession
domain ACT domain 626 - 705 IPR002912
domain HD/PDEase domain 41 - 166 IPR003607
domain TGS 387 - 448 IPR004095
domain HD domain 45 - 144 IPR006674
domain RelA/SpoT 214 - 345 IPR007685
domain RelA/SpoT, TGS domain 390 - 447 IPR033655
domain RelA/SpoT, AH and RIS domains 461 - 544 IPR045600

Functions

Description
EC Number 3.1.7.2 Diphosphoric monoester hydrolases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
GTP diphosphokinase activity Catalysis of the reaction: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate.
guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate.

3 GO annotations of biological process

Name Definition
guanosine tetraphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates.
guanosine tetraphosphate metabolic process The chemical reactions and pathways involving guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates.
response to starvation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MYLFDSLKDV AQEYLTEPQI EALRQSYVVA RDAHEGQTRS SGEPYIIHPV AVARILAEMR
70 80 90 100 110 120
LDLETLQAAL LHDVIEDCDV TKEDLDAHFG SSVAELVDGV SKLDKLKFRD RKEAQAENFR
130 140 150 160 170 180
KMVLAMVQDI RVILIKLADR TPNMRTLGAL RPDKKRRIAR ETLEIYAPLA HRLGIHNIKT
190 200 210 220 230 240
ELEELGFEAL YPNRYRVLKE VVKAARGNRK EMIQRIHSEI EGRLQEVGLP ARVVGREKNL
250 260 270 280 290 300
FSIYNKMKTK EQRFHTIMDI YAFRIVVDTA DTCYRVLGQV HSLYKPRPAR MKDYIAVPKA
310 320 330 340 350 360
NGYQSLHTSM VGPHGVPVEV QIRTEDMDQM ADKGVAAHWS YKANSERGGT TAQIKAQRWM
370 380 390 400 410 420
QSLLELQQSA GNSFEFIENV KSDLFPDEIY VFTPKGRIVE LPMGATAVDF AYAVHTDIGN
430 440 450 460 470 480
TCVGARVDRT PYPLSQSLKS GQTVEIISAP GARPNAAWLN YVVTSRARTK IRQVLKTMRR
490 500 510 520 530 540
EDSITLGRRL LNHALGEHSV NEIAPENISK VLSDLKIASM DDLLAAIGLG ELMSIVIARR
550 560 570 580 590 600
LLGNADELTE PSKSGGNKNK LPIRGAEGIL LTFANCCHPI PDDHIIAHVS PGRGLVVHRE
610 620 630 640 650 660
TCPNVRGYQK EPDKYMAVEW TKDYDQEFIT ELKVDMHNRQ GALAELTNVI SKTGSNIHGL
670 680 690 700
STEERDGRLY TVTVLLTTKD RVHLAGIMRK IRTMPHALKV RRRKN