Q9KNA8

PR
Gene name
phrA (VcPhr, VC_A0057)
Protein name
Deoxyribodipyrimidine photo-lyase
Names
DNA photolyase, Photoreactivating enzyme
Species
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
KEGG Pathway
vch:VC_A0057
EC number
4.1.99.3: Other carbon-carbon lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

62-146 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9KNA8

Entry ID Method Resolution Chain Position Source
AF-Q9KNA8-F1 Predicted AlphaFoldDB

No variants for Q9KNA8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9KNA8

No associated diseases with Q9KNA8

4 regional properties for Q9KNA8

Type Name Position InterPro Accession
domain Cryptochrome/DNA photolyase, FAD-binding domain 273 - 465 IPR005101
domain DNA photolyase, N-terminal 1 - 164 IPR006050
conserved_site Cryptochrome/DNA photolyase class 1, conserved site, C-terminal 323 - 335 IPR018394-1
conserved_site Cryptochrome/DNA photolyase class 1, conserved site, C-terminal 343 - 362 IPR018394-2

Functions

Description
EC Number 4.1.99.3 Other carbon-carbon lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
deoxyribodipyrimidine photo-lyase activity Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
FAD binding Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.

2 GO annotations of biological process

Name Definition
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
response to light stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRLVWFRRDL RSFDNTALTA ALNSGDPVAA MYIATPEQWH QHHLAPIQAD LIWRRLAELQ
70 80 90 100 110 120
QELAALNVPL FYQQVADFQA AAVAVSQLAK TLNATQVLAN RDYELDEQQR DQLAQQLLSE
130 140 150 160 170 180
QGIIWSAFDD KCVLPPGSVR TKQGEFFKVF TPFKRAWLTL FQPPVIGKNR PVALWNVPSA
190 200 210 220 230 240
LAELVWHPEQ AFDYPRIDST PWAADFETVR AQLRDFCRER VQDYHQARDF PAREGTSSLS
250 260 270 280 290 300
PYLAIGVLSA RQCVARLYHE SSMGELSEGA QVWLSELIWR EFYQHLVAIE PNLSKSRDFV
310 320 330 340 350 360
EWGARLEWWN DNEKFQLWCE GKTGYPIVDA AMRQLNQTGW MHNRLRMIVA SFLTKDLHID
370 380 390 400 410 420
WRWGERYFMS RLIDGDYAAN NGGWQWCAST GCDGQPYFRI FNPVSQGEKF DPNGDFIRRW
430 440 450 460
VPELRSVSSA YIHQPWTYPA VNSVLYPARL VDHKQEREVT LRLYKTAKG