Q9KGF7

PR
Gene name
ispF
Protein name
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Names
MECDP-synthase, MECPP-synthase, MECPS
Species
Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) (Bacillus halodurans)
KEGG Pathway
bha:BH0108
EC number
4.6.1.12: Phosphorus-oxygen lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

108-157 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9KGF7

Entry ID Method Resolution Chain Position Source
AF-Q9KGF7-F1 Predicted AlphaFoldDB

No variants for Q9KGF7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9KGF7

No associated diseases with Q9KGF7

2 regional properties for Q9KGF7

Type Name Position InterPro Accession
domain 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 2 - 157 IPR003526
conserved_site 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, conserved site 36 - 51 IPR020555

Functions

Description
EC Number 4.6.1.12 Phosphorus-oxygen lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity Catalysis of the reaction: 4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP.
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate.
terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIRVGQGFDV HQFAEGRLLI IGGVEIPYEK GLLGHSDADV LLHTIADAAL GAIGEGDIGK
70 80 90 100 110 120
HFPDTDPHFK DADSAKLLSA VWELVKEKGY TLGNVDCTII AQKPKMAPHI PAMRARIAEL
130 140 150
LEAEEAQVNV KATTTETLGF TGRGEGIASQ AVILLVK