Q9KA72
Gene name |
polC |
Protein name |
DNA polymerase III PolC-type |
Names |
PolIII |
Species |
Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) (Bacillus halodurans) |
KEGG Pathway |
bha:BH2418 |
EC number |
2.7.7.7: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9KA72
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9KA72-F1 | Predicted | AlphaFoldDB |
No variants for Q9KA72
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9KA72 | |||||
No associated diseases with Q9KA72
1 regional properties for Q9KA72
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Thiamine pyrophosphate enzyme, TPP-binding | 43 - 205 | IPR011766 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.7 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 3'-5' exonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-directed DNA polymerase activity | Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA-templated DNA replication | A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNEEQRVRQE | RFKLLMEQLL | IPEDVTANHL | KDGKIEKLTI | KKDERRWHFQ | LSIPTVLPAS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IYELLADRLV | QTFSHIAKVS | FQIQYGQPDL | SEQVWQSYWP | LIVAKLTNIS | QPLKEMLEKQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TPRFDGKRLV | IQVGNETEAI | ALKRKLTEPL | QQAVQSFGFP | AVQLDAEVKE | SKQAFEKFVE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QRKQEDHSKV | VEAILEKKKL | EQQVEKKMKE | EKLTIGYPIK | DEPVPLETIV | EEERRITVQG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YIFAAETKEL | RSGRTLLTFK | ITDYTDSILV | KMFSRDKEDI | PLLQAVKKGM | WVKVRGGVQN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DTFVRDLVMI | ANDVNEVSGK | ETKDEAPDDE | KRVELHLHTA | MSQMDGISSA | GAYVTQASKW |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GHKAIAITDH | GVVQAFPEAY | GASQKHGIKV | IYGVEANLVD | DGVPIAYNEA | HIPLLDSEFV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VFDVETTGLS | AVYNKIIELA | AVKVKNGEII | DRFERFADPH | EPLTNTIIEL | TGITDDMLKG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QPEVEQVLNE | FHAFIGDAVL | VAHNASFDMG | FLNTGFQKMG | LGEAKNPVID | TLELGRFLYP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TLKNHRLNTL | CKKFDIELVS | HHRAIYDAEA | TGHLLWRMVK | DATERDILYH | DQLNDNMGEG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NFHRQRPSHC | ILLAQTQEGL | KNLYKLVSMA | HVEYFYRTPR | IPRSQLQKHR | EGILVGSGCD |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KGEVFEGMMQ | KTPQEVEEIA | KFYDYIEVQP | LANYEHLIEK | ELVKSREALQ | EIVANIVKLG |
| 730 | 740 | 750 | 760 | 770 | 780 |
| EQLGKPVVAT | GNAHYLKEED | YIYRKILIAS | QGGANPLNKQ | TLPQVHFRTT | SEMLEAFAFL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| GEEKAKEIVV | TNTNHIADQI | EEIHPIPDKL | YTPKIEGADE | EIRQMSYNRA | RKIYGDPLPE |
| 850 | 860 | 870 | 880 | 890 | 900 |
| IVEARLEKEL | KSIIGHGFAV | IYLISHKLVK | KSLDDGYLVG | SRGSVGSSFV | ATMTEITEVN |
| 910 | 920 | 930 | 940 | 950 | 960 |
| PLPPHYVCPN | CHHSHFFNDG | SVGSGYDLPD | ENCPKCGTPY | VKDGQDIPFE | TFLGFKGDKV |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| PDIDLNFSGE | YQPRAHNYTK | ELFGESYVYR | AGTIGTVAEK | TAYGYVKGYQ | SDHDLHFRGA |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| EIDRLVTGCT | GVKRTTGQHP | GGIIVVPDYM | DIHDFCPIQF | PADDRGAEWK | TTHFDFHSIH |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| DNLLKLDILG | HDDPTVIRML | QDLSGIDPKT | IPTDDPEVMK | IFSGPDVLGV | TEEQILCKTG |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| TLGIPEFGTR | FVRQMLEETK | PSTFSELVQI | SGLSHGTDVW | LNNANELIYN | GTCELKDVIG |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| CRDDIMVYLI | YKGLEPSLAF | KIMEFVRKGK | GLQPEWIEEM | KKHDVPDWYI | GSCLKIKYMF |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| PKAHAAAYVL | MAVRIAYFKV | HYPILYYASY | FTVRADDFDL | DTMVKGSAAI | RAKIEEINGK |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| GLDASPKEKS | LLTVLELALE | MVERGFSFQK | VDLYRSEATE | FLVEGNTLIP | PFNALTGVGT |
| 1390 | 1400 | 1410 | 1420 | 1430 | |
| NAAINIVKAR | DEREFLSKED | LQQRSKITKT | VLENLDAHGC | LEGLPESNQL | SLF |