Q9K9H0

PR
Gene name
aceA (BH2677)
Protein name
Isocitrate lyase
Names
ICL, Isocitrase, Isocitratase
Species
Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) (Bacillus halodurans)
KEGG Pathway
bha:BH2677
EC number
4.1.3.1: Oxo-acid-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

348-427 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9K9H0

Entry ID Method Resolution Chain Position Source
AF-Q9K9H0-F1 Predicted AlphaFoldDB

No variants for Q9K9H0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9K9H0

No associated diseases with Q9K9H0

2 regional properties for Q9K9H0

Type Name Position InterPro Accession
conserved_site Isocitrate lyase/phosphorylmutase, conserved site 186 - 191 IPR018523
domain ICL/PEPM domain 54 - 359 IPR039556

Functions

Description
EC Number 4.1.3.1 Oxo-acid-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
isocitrate lyase activity Catalysis of the reaction: isocitrate = glyoxylate + succinate.
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
glyoxylate cycle A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate.
tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSGWQETAEK LEMSWSNDVR WQGVERPYSG EEVVKLRGSL KIEYTLAKTG AEKLWKLLHE
70 80 90 100 110 120
EDYVNALGAM TGGQAIQQVK AGLKAIYLSG WQVAADANLA GHMYPDQSLY PANSVPSVVK
130 140 150 160 170 180
RINQALQRAD QIQHLEGEGE VDYFAPIVAD AEAGFGGQLN VFELMKAMIE AGASGVHFED
190 200 210 220 230 240
QLASEKKCGH LGGKVLIPTQ TAIRNLVSAR LAADVMGVPT ILVARTDADA ADLITSDIDP
250 260 270 280 290 300
ADQRFITGER TPEGFYRTNA GIEQAIARGL AYAPYADLIW CETSKPSLEE AKQFADAIHE
310 320 330 340 350 360
KFPGKLLAYN CSPSFNWEAN LDRATIETFQ QELGKMGYKF QFVTLAGFHA LNHSMFELAY
370 380 390 400 410 420
GYKQRGMGAY SELQQAEFAS EVKGYTATRH QREVGTGYFD QVAQTITGGT SSTTALTGST
EEAQFQK