Q9K4B1
Gene name |
hisN |
Protein name |
Histidinol-phosphatase |
Names |
HolPase, Histidinol-phosphate phosphatase |
Species |
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) |
KEGG Pathway |
sco:SCO5208 |
EC number |
3.1.3.15: Phosphoric monoester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9K4B1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9K4B1-F1 | Predicted | AlphaFoldDB |
No variants for Q9K4B1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9K4B1 | |||||
No associated diseases with Q9K4B1
1 regional properties for Q9K4B1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| binding_site | Inositol monophosphatase, metal-binding site | 81 - 94 | IPR020583 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.3.15 | Phosphoric monoester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| histidinol-phosphatase activity | Catalysis of the reaction: L-histidinol phosphate + H(2)O = L-histidinol + phosphate. |
| metal ion binding | Binding to a metal ion. |
| phosphatase activity | Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. |
| phosphoric ester hydrolase activity | Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| histidine biosynthetic process | The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. |
| inositol phosphate dephosphorylation | The process of removing a phosphate group from any mono- or polyphosphorylated inositol. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPDYLDDLRL | AHVLADAADA | ATMDRFKALD | LKVETKPDMT | PVSEADKAAE | ELIRGHLSRA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RPRDSVHGEE | FGVAGTGPRR | WVIDPIDGTK | NYVRGVPVWA | TLIALMEAKE | GGYQPVVGLV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SAPALGRRWW | AVEDHGAFTG | RSLTSAHRLH | VSQVSTLSDA | SFAYSSLSGW | EEQGRLDGFL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DLTREVWRTR | AYGDFWPYMM | VAEGSVDLCA | EPELSLWDMA | ANAIIVTEAG | GTFTGLDGRP |
| 250 | 260 | ||||
| GPHSGNAAAS | NGRLHDELLG | YLNQRY |