Q9K1Q0
Gene name |
metG |
Protein name |
Methionine--tRNA ligase |
Names |
Methionyl-tRNA synthetase, MetRS |
Species |
Neisseria meningitidis serogroup B (strain MC58) |
KEGG Pathway |
nme:NMB0030 |
EC number |
6.1.1.10: Ligases forming aminoacyl-tRNA and related compounds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9K1Q0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9K1Q0-F1 | Predicted | AlphaFoldDB |
No variants for Q9K1Q0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9K1Q0 | |||||
No associated diseases with Q9K1Q0
1 regional properties for Q9K1Q0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | NAD-dependent epimerase/dehydratase | 2 - 246 | IPR001509 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.1.1.10 | Ligases forming aminoacyl-tRNA and related compounds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| metal ion binding | Binding to a metal ion. |
| methionine-tRNA ligase activity | Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met). |
| tRNA binding | Binding to a transfer RNA. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| methionyl-tRNA aminoacylation | The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTRKILVTSA | LPYANGSIHL | GHMVEHIQTD | VWVRFQKLRG | HACHYCCADD | THGTPVMLAA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QKQGIAPEDM | IAKVREEHLA | DFTGFFIGYD | NYYSTHSPEN | KQFSQDIYRA | LKANGKIESR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VIEQLFDPEK | QMFLPDRFVK | GECPKCHAQD | QYGDNCEVCG | TTYSPTELIN | PYSAVSGTKP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ELRESEHFFF | KLGECADFLK | AWTSGNNPHD | GKPHLQAEAL | NKMKEWLGEG | EETTLSDWDI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SRDAPYFGFE | IPDAPGKYFY | VWLDAPVGYM | ASFKNLCDRI | GVDFDEYFKA | DSQTEMYHFI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GKDILYFHAL | FWPAMLHFSG | HRAPTGVYAH | GFLTVDGQKM | SKSRGTFITA | KSYLEQGLNP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EWMRYYIAAK | LNSKIEDIDL | NLQDFISRVN | SDLVGKYVNI | AARASGFIAK | RFEGRLKDVA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DSELLAKLTA | QSEAIAECYE | SREYAKALRD | IMALADIVNE | YVDANKPWEL | AKQEGQDERL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| HEVCSELINA | FTMLTAYLAP | VLPQTAANAA | KFLNLEAITW | ANTRDTLGKH | AINKYEHLMQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RVEQKQVDDL | IEANKQSIAA | AAAPAAEEGK | YEKVAEQASF | DDFMKIDMRV | AKVLNCEAVE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GSTKLLKFDL | DFGFEKRIIF | SGIAASYPNP | AELNGRMVIA | VANFAPRKMA | KFGVSEGMIL |
| 670 | 680 | ||||
| SAATADGKLK | LLDVDTGAQP | GDKVG |