Q9K062

PR
Gene name
pnp
Protein name
Polyribonucleotide nucleotidyltransferase
Names
Polynucleotide phosphorylase, PNPase
Species
Neisseria meningitidis serogroup B (strain MC58)
KEGG Pathway
nme:NMB0758
EC number
2.7.7.8: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

49-120 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9K062

Entry ID Method Resolution Chain Position Source
AF-Q9K062-F1 Predicted AlphaFoldDB

No variants for Q9K062

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9K062

No associated diseases with Q9K062

8 regional properties for Q9K062

Type Name Position InterPro Accession
domain Exoribonuclease, phosphorolytic domain 1 16 - 145 IPR001247-1
domain Exoribonuclease, phosphorolytic domain 1 326 - 458 IPR001247-2
domain S1 domain 620 - 693 IPR003029
domain K Homology domain 553 - 618 IPR004087
domain K Homology domain, type 1 558 - 615 IPR004088
domain Exoribonuclease, phosphorolytic domain 2 148 - 210 IPR015847
domain Polyribonucleotide nucleotidyltransferase, RNA-binding domain 242 - 322 IPR015848
domain RNA-binding domain, S1 621 - 693 IPR022967

Functions

Description
EC Number 2.7.7.8 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

4 GO annotations of molecular function

Name Definition
3'-5'-exoribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
magnesium ion binding Binding to a magnesium (Mg) ion.
polyribonucleotide nucleotidyltransferase activity Catalysis of the reaction: RNA(n+1) + phosphate <=> RNA(n) + a nucleoside diphosphate.
RNA binding Binding to an RNA molecule or a portion thereof.

3 GO annotations of biological process

Name Definition
mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
RNA catabolic process The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MMFDKHVKTF QYGNQTVTLE TGEIARQAAA AVKVSMGDTV VLVAVTTNKE VKEGQDFFPL
70 80 90 100 110 120
TVDYLERTYA AGKIPGGFFK REGKQSEKEI LTSRLIDRPI RPLFPEGFYH DIQIVAMVVS
130 140 150 160 170 180
VDPEIDSDIP AMLGASAALV LSGVPFAGPI GAARVGYVNG VYVLNPTKAE LAKSQLDLVV
190 200 210 220 230 240
AGTSKAVLMV ESEAKILPED VMLGAVVYGH DQMQVAINAI NEFADEVNPE LWDWKAPETN
250 260 270 280 290 300
EELVAKVRGI AGETIKEAFK IRQKQARSAK LDEAWSAVKE ALITEETDTL AANEIKGIFK
310 320 330 340 350 360
HLEADVVRSQ ILDGQPRIDG RDTRTVRPLN IQTSVLPRTH GSALFTRGET QALAVATLGT
370 380 390 400 410 420
SRDEQIIDAL SGEYTDRFML HYNFPPYSTG EVGRMGAPKR REIGHGRLAK RALLAVLPKP
430 440 450 460 470 480
EDFSYTMRVV SEITESNGSS SMASVCGGCL SLLSAGVPLK AHVAGIAMGL ILEGNKFAVL
490 500 510 520 530 540
TDILGDEDHL GDMDFKVAGT TEGVTALQMD IKIQGITKEI MQIALAQAKE ARLHILDQMK
550 560 570 580 590 600
AAVAGPQELS AHAPRLFTMK INQDKIREVI GKGGETIRSI TAETGTEINI AEDGTITIAA
610 620 630 640 650 660
TTQEAGDAAK KRIEQITAEV EVGKVYEGTV VKILDNNVGA IVSVMPGKDG LVHISQIAHE
670 680 690 700
RVRNVGDYLQ VGQVVNVKAL EVDDRGRVRL SIKALLDAPA REENAAE